Amelioration Potential of Piperine on Cypermethrin-Induced Immunotoxicity in Wistar Rats
DOI:
https://doi.org/10.48165/ijvsbt.20.2.19Keywords:
Cypermethrin, Immunomodulation, Piperine, RatsAbstract
The aim of the present study was to evaluate the immunemodulatory potential of piperine against cypermethrin-induced immune dysfunction in a rat model. Thirty rats were divided into five groups of six each. Group I was kept as control and group II was used as vehicle control. Groups III, IV and V were administered orally with cypermethrin (25 mg/kg, b.wt., per oral), piperine (50 mg/kg, b.wt., per oral) and both daily for 4 weeks, respectively. Subchronic exposure to cypermethrin significantly reduced body weight, total leukocyte count, lymphocyte count, serum total protein, serum albumin, serum globulin, antibody titer against sheep red blood cells, and cell mediated immunity. Simultaneous piperine administration restored the changes in the body weight, haematological parameters, and serum biochemical indices and significantly increased the antibody titer and cell mediated immunity. These results suggest that simultaneous piperine treatment has restore the number of factors known to be involved in the cypermethrin induced immunotoxicity which indicates that piperine can be used as a safe and effective therapy for environmental contaminants induced immunotoxicity.
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