Amelioration Potential of Piperine on Cypermethrin-Induced Immunotoxicity in Wistar Rats

Authors

  • Palanisamy Sankar Department of Veterinary Pharmacology and Toxicology, Veterinary College and Research Institute, Namakkal, 637002, Tamil Nadu, India
  • Avinash Gopal Telang Division of Veterinary Pharmacology & Toxicology, Indian Veterinary Research Institute, Izatnagar, Bareilly-243122, Uttar Pradesh, India.

DOI:

https://doi.org/10.48165/ijvsbt.20.2.19

Keywords:

Cypermethrin, Immunomodulation, Piperine, Rats

Abstract

The aim of the present study was to evaluate the immunemodulatory potential of piperine against cypermethrin-induced immune  dysfunction in a rat model. Thirty rats were divided into five groups of six each. Group I was kept as control and group II was used as  vehicle control. Groups III, IV and V were administered orally with cypermethrin (25 mg/kg, b.wt., per oral), piperine (50 mg/kg, b.wt., per  oral) and both daily for 4 weeks, respectively. Subchronic exposure to cypermethrin significantly reduced body weight, total leukocyte  count, lymphocyte count, serum total protein, serum albumin, serum globulin, antibody titer against sheep red blood cells, and cell mediated immunity. Simultaneous piperine administration restored the changes in the body weight, haematological parameters,  and serum biochemical indices and significantly increased the antibody titer and cell mediated immunity. These results suggest that  simultaneous piperine treatment has restore the number of factors known to be involved in the cypermethrin induced immunotoxicity  which indicates that piperine can be used as a safe and effective therapy for environmental contaminants induced immunotoxicity.  

Downloads

Download data is not yet available.

References

Abdul-Hamid, M., Moustafa, N., Asran, A., & Mowafy, L. (2017). Cypermethrin-induced histopathological, ultrastructural and biochemical changes in liver of albino rats: The protective role of propolis and curcumin. Beni-Suef University Journal of Basic and Applied Sciences, 6, 160-173.

Afolabi, O.K., Aderibigbe, F.A., Folarin, D.T., Arinola, A., & Wusu, A.T. (2019). Oxidative stress and inflammation following sub-lethal oral exposure of cypermethrin in rats: Mitigating potential of epicatechin. Heliyon, 5(8), e02274.

Ambwani, S., Ambwani, T.K., & Singh R. (2018). Immunotoxic effects of cypermethrin in mitogen stimulated chicken lymphocytes due to oxidative stress and apoptosis. Journal of Entomology and Zoology Studies, 6(2), 37-42.

Beard, C.W. (1980). Serological procedure. Isolation and identification of avian pathogens. 2nd edn. Creative Printing Company, New York, USA., PP 129–135.

Burns, C.J., & Pastoor, T.P. (2018). Pyrethroid epidemiology: A quality based review. Critical Reviews in Toxicology, 48, 297-311. El Elaimy, I.A., Bayomy, F.F., Salem, T.A., & Ibrahim, H.M. (2013). Immune -toxicity of synthetic pyrethroids: Modulation of cypermethrin and permethrin toxicity by tamoxifen. Delta Journal of Sciences, 36, 123-138.

Fenga, C., Giusi, B., & Chiara, C. (2021). Immunotoxicity of pesticides: current knowledge and perspectives. In: Tsatsakis, A.M. (Eds.) Toxicological Risk Assessment and Multi-System Health Impacts from Exposure. Academic Press, London, UK., pp. 557.

Gangemi, S., Gofita, E., & Costa, C. (2016). Occupational and environmental exposure to pesticides and cytokine pathways in chronic diseases. International Journal of Molecular Medicine, 38, 1012-1020.

Grewal, G., Verma, P.K., Dhar, V., & Srivastava, A.K. (2009). Toxicity of subacute oral administration of cypermethrin in rats with special reference to histopathological changes. International Journal of Green Pharmacy, 3(4), 1-5.

Iahtisham-Ul Haq, Imran, M., Nadeem, M., Tufail, T., Gondal, T.A., & Mubarak, M.S. (2021). Piperine: A review of its biological effects. Phytotherapy Research, 35(2), 680-700.

Khurana, S.K., Chauhan, R.S. & Mahipal, S.K. (1999). Immunotoxic effects of cypermethrin on delayed type hypersensitivity reaction in chicken. Indian Veterinary Journal, 76, 1055–1057.

Paramanik, A., Chaudhuri, A.D., & Chakraborty, B. (2021). Immunotoxic effects of cypermethrin in male Wistar rats: Attenuation by co-administration of zinc and alphalipoic acid. Toxicology and Forensic Medicine Open Journal, 6(1), 1-8.

Pathak, N., & Khandelwal, S. (2009). Immunomodulatory role of piperine in cadmium induced thymic atrophy and splenomegaly in mice. Environmental Toxicology and Pharmacology, 28(1), 52-60.

Sankar, P., Telang, A. G., & Ramya, K. (2023). Effect of piperine on cypermethrin-Induced genotoxicity in Wistar rat. The Indian Journal of Veterinary Science & Biotechnology, 19(5), 105-107.

Selvendiran, K., & Sakthisekaran, D. (2004). Chemopreventive effect of piperine on modulating lipid peroxidation and membrane bound enzymes in benzo(a) pyrene induced lung carcinogenesis. Biomedical Pharmacotherapy, 58, 264-267.

Shakoori, A.R., Aziz, F., Alam, J., & Ali, S.S. (1990). Toxic effect of talastar a new synthetic pyrethroid, on blood and liver of rabbit. Pakistan Journal of Zoology, 23, 289–293.

Venkateshwarlu, P., Sharma, B.J.R., Kalakumar, B., Reddy., and K.S. & Ravikumar, P. (1997). Comparative evaluation of toxicity of carbaryl, cypermethrin and malathion of testis in mice. Indian Journal of Toxicology, 4, 33–37.

Vimal, A. & Kumar, A. (2019). Transforming the healthcare system through therapeutic enzymes. Enzymes Food & Biotechnology, 1, 603-625.

Yoo, S., Kim, K., Nam, H., & Lee, D. (2018). Discovering health benefits of phytochemicals with integrated analysis of the molecular network, chemical properties and ethnopharmacological evidence. Nutrients, 10, 1042-1048.

Downloads

Published

2024-03-10

Issue

Vol. 20 No. 2 (2024): The Indian Journal of Veterinary Sciences and Biotechnology (IJVSBT) (Mar-Apr) 2024

Section

Research Article

License

Copyright (c) 2024 Indian Journal of Veterinary Sciences & Biotechnology

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

How to Cite

Sankar, P., & Telang, A.G. (2024). Amelioration Potential of Piperine on Cypermethrin-Induced Immunotoxicity in Wistar Rats . Indian Journal of Veterinary Sciences and Biotechnology, 20(2), 90–93. https://doi.org/10.48165/ijvsbt.20.2.19
Crossref
Scopus
Google Scholar
Europe PMC