Study on the Anti-snake venom property of Cabbage

Naresh Kumar

doi:10.55524/

Authors

Naresh Kumar Assistant Professor, School of Bio Sciences, RIMT University, Mandi Gobindgarh, Punjab, India Author

DOI:

https://doi.org/10.55524/

Keywords:

Antidote, Anti-Snake Venom, Clotting, Concentration, Minimum Coagulant Dosage

Abstract

Snake poison causes death and tissue disfiguration among the rural people. Though anti-dote or anti-snake venom serum is freely accessible at government health care facilities but is hampered by poor handling, storage and lack of specificity. The necessity of the hour is to find new anti-dotes which are not only inexpensive but can work against a broad variety of snake venoms. In India, most of the poisonous snakes belong to the Elapidae & Viperidae families. In this study, venom of the Flavonoids has been found to have anti-snake venom action owing to which the cabbage was chosen for its high flavonoid content. For this, initially the effective concentration of the Russell’s viper was found on goat’s plasma at 4.54 ��g/mL and the aqueous extract of cabbage was observed to inhibit proteolysis. Next, the minimal coagulant dosage (MCD) was estimated as 3.69 µg/ml for goat’s plasma and the aqueous extract of cabbage was found to delay venom induced plasma clotting. An examination of these findings suggest that cabbage may be utilized a source of anti-snake venom.

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References

Gupta YK, Peshin SS. Do herbal medicines have potential for managing snake bite envenomation? Toxicology International. 2012.

Sebastin Santhosh M, Hemshekhar M, Sunitha K, M. Thushara R, Jnaneshwari S, Kemparaju K, et al. Snake Venom Induced Local Toxicities: Plant Secondary Metabolites as an Auxiliary Therapy. Mini-Reviews Med Chem. 2013;

S. Girish K, Kemparaju K. Overlooked Issues of Snakebite Management: Time for Strategic Approach. Curr Top Med Chem. 2011;

Alam MI. Inhibition of Toxic Effects of Viper and Cobra Venom by Indian Medicinal Plants. Pharmacol & Pharm. 2014;

Ghai DP, Vyas S, Senthilkumaran P, Sirohi RS. Detection of phase singularity using a lateral shear interferometer. Opt Lasers Eng. 2008;

Tripathi L, Kumar P, Singh R. A Review on Extraction, Synthesis and Anticancer Activity of Betulinic Acid. Curr Bioact Compd. 2009;

Verma KG, Kaushik BK, Singh R. Effects of process variation in VLSI interconnects - A technical review. Microelectron Int. 2009;

Abbasi MU, Abbasi TA, Yameen M, Kumar V. A low leakage single supply level shifter design for multi voltage systems. In: 2009 16th IEEE International Conference on Electronics, Circuits and Systems, ICECS 2009. 2009.

Kumar N, Verma N, Songh O, Joshi N, Singh KG. Estimation of atenolol by reverse phase high performance liquid chromatography. E-Journal Chem. 2010;

Nnamani C V, Ukwa E V. Taxonomic diversity of medicinal plants utilized for traditional management of snakebite in southeast , Nigeria : Conservation for sustainability. Int J Dev Sustain. 2015;4(12):1138–52.

Vaddi R, Dasgupta S, Agarwal RP. Device and circuit co design robustness studies in the subthreshold logic for ultralow-power applications for 32 nm CMOS. IEEE Trans Electron Devices. 2010;

Kumari R, Chatterjee M, Singh S, Kaundal M, Ashwalayan VD. Oxidative stress: A novel treatment target in psychiatric disorder. International Journal of Pharmaceutical Sciences Review and Research. 2011.

Salmani MH, Rehman S, Zaidi K, Hasan AK. Study of ignition characteristics of microemulsion of coconut oil under off diesel engine conditions. Eng Sci Technol an Int J. 2015;

Agarwal A, Singh BK, Trivedi N, Jha KK. Approaches for enhancement of solubility to improve the absorption and bioavailability of poorly soluble drugs. Pharma Res. 2014;

Kumar A, Mittal A, Kishore Jha K. Formulation and evaluation of CAP microparticles for sustained release delivery of Ondansetron hydrochloride. Russ J Biopharm. 2013;

Singh AP, Chandak S, Agarwal A, Malhotra A, Jain A, Khan AA. Utility of High-Resolution Sonography for Evaluation of Knee Joint Pathologies as a Screening Tool. J Diagnostic Med Sonogr. 2021;

Preciado LM, Comer J, Núñez V, Rey-Súarez P, Pereañez JA. Inhibition of a snake venom metalloproteinase by the flavonoid myricetin. Molecules. 2018;

Mageney V, Neugart S, Albach DC. A guide to the variability of flavonoids in Brassica oleracea. Molecules. 2017.

Naguib AEMM, El-Baz FK, Salama ZA, Abd El Baky Hanaa H, Ali HF, Gaafar AA. Enhancement of phenolics, flavonoids and glucosinolates of Broccoli (Brassica olaracea, var. Italica) as antioxidants in response to organic and bio-organic fertilizers. J Saudi Soc Agric Sci. 2012;

Valverde J, Reilly K, Villacreces S, Gaffney M, Grant J, Brunton N. Variation in bioactive content in broccoli (Brassica oleracea var. italica) grown under conventional and organic production systems. J Sci Food Agric. 2015;

De Oliveira EC, Fernandes CP, Sanchez EF, Rocha L, Fuly AL. Inhibitory effect of plant Manilkara subsericea against biological activities of Lachesis muta snake venom. Biomed Res Int. 2014;

Upadhyay GK, Pathak TK, Purohit LP. Heterogeneous Ternary Metal Oxide Nanocomposites for Improved Advanced Oxidation Process under Visible Light. Cryst Res Technol. 2020;

Pathak D, Singh RP, Gaur S, Balu V. Influence of groove angle on hardness and reinforcement height of shielded metal arc welded joints for low carbon AISI 1016 steel plates. In: Materials Today: Proceedings. 2020.

Stojkovikj S, Oklevski S, Jasuja OP, Najdoski M. Visualization of latent fingermarks on thermal paper: A new method based on nitrogen dioxide treatment. Forensic Chem. 2020;

Sharma K, Goswami L. RFID based Smart Railway Pantograph Control in a Different Phase of Power Line. In: Proceedings of the 2nd International Conference on Inventive Research in Computing Applications, ICIRCA 2020. 2020.