Aspects to Consider While Developing Therapeutic Monoclonal Antibodies
DOI:
https://doi.org/10.55524/Keywords:
Biologics, Drug Interference, Drug Tolerance, Immunogenicity Assay, Immunogenicity RateAbstract
Probably preponderance of exogenous protein therapeutics are still in the research phase. Numerous goods have been sold worldwide in 2006. The US Food and Drug Administration (FDA) has accepted an overwhelming amount of Immunotherapy Development Drug (IND) registrations for therapeutics immunotherapies during the past several years (mAbs). Mice bearing immunotherapy (mAbs) were just the first special proteins (mAbs) to be tested in clinical testing. They have a long service, are poor at rousing enzymatic activities, and seem to be exceedingly biocompatible, notwithstanding the treatments' current advancement. mAbs were developed as a consequence of the synthesis of hybrid and portrayed immunoglobulin. Immunotherapies as well as related products are all being investigated for a number of diseases. In addition, the number of specific antibodies sector is growing, especially IgG2/IgG4 subcategories and changed Fc regions that may increase or reduce antibodies cytokine production. Recent findings highlight the need of learning more about these goods and how they work. Innovations in material profiling methods, sensitivity assessments, and certain other biomedical testing may be used to help understand process efficiency employed.
Downloads
References
Kimiz-Gebologlu I, Gulce-Iz S, Biray-Avci C. Monoclonal antibodies in cancer immunotherapy. Molecular Biology Reports. 2018.
Aliya S, Kaur H, Garg N, Rishika, Yeluri R. Clinical Measurement of Maximum Mouth Opening in Children Aged 6-12. J Clin Pediatr Dent. 2021;
Agarwal A, Raj Singh M, Joon P. Sonourethrography With Pharmaco-Penile Doppler in Penile Fractures: A Complete and Productive Imaging Combination. J Diagnostic Med Sonogr. 2021;
Matreja PS, Kaur J, Yadav L. Acceptability of the use of crossword puzzles as an assessment method in pharmacology. J Adv Med Educ Prof. 2021;
Liu JKH. The history of monoclonal antibody development - Progress, remaining challenges and future innovations. Annals of Medicine and Surgery. 2014.
Maini E, Venkateswarlu B, Maini B, Marwaha D. Machine learning–based heart disease prediction system for Indian population: An exploratory study done in South India. Med J Armed Forces India. 2021;
Ecker DM, Jones SD, Levine HL. The therapeutic monoclonal antibody market. mAbs. 2015.
Mahat RK, Panda S, Rathore V, Swain S, Yadav L, Sah SP. The dynamics of inflammatory markers in coronavirus disease-2019 (COVID-19) patients: A systematic review and meta-analysis. Clinical Epidemiology and Global Health. 2021.
Cox H, Loveday M. Building resilience needs to be central to treating drug-resistant tuberculosis. The Lancet Global Health. 2021.
Singh AP, Chandak S, Agarwal A, Malhotra A, Jain A, Khan AA. Utility of High-Resolution Sonography for Evaluation of Knee Joint Pathologies as a Screening Tool. J Diagnostic Med Sonogr. 2021;
Lee JT, Cha JK, Kim S, Jung UW, Thoma DS, Jung RE. Lateral onlay grafting using different combinations of soft type synthetic block grafts and resorbable collagen membranes: An experimental in vivo study. Clin Oral Implants Res. 2020;
Agarwal A, Agarwal S. Morbid Adherent Placenta Score: A Simple and Practical Approach on Application of Placenta Accreta Index. Journal of Ultrasound in Medicine. 2021.
Chauhan A, Tyagi V V, Sawhney A, Anand S. Comparative enviro-economic assessment and thermal optimization of two distinctly designed and experimentally validated PV/T collectors. J Therm Anal Calorim. 2021;
Khatri M, Kumar A. Stability Inspection of Isolated Hydro Power Plant with Cuttlefish Algorithm. In: 2020 International Conference on Decision Aid Sciences and Application, DASA 2020. 2020.
Lisak M, Bašić Kes V. Monoclonal antibodies in the treatment of multiple sclerosis. Acta Medica Croat. 2018;
Hussain S, Singh A, Habib A, Hussain MS, Najmi AK. Comment on: “Cost Effectiveness of Dialysis Modalities: A Systematic Review of Economic Evaluations.” Applied Health Economics and Health Policy. 2019.
Wang YMC, Fang L, Zhou L, Wang J, Ahn HY. A survey of applications of biological products for drug interference of immunogenicity assays. Pharmaceutical Research. 2012.
Catlos EJ, Perez TJ, Lovera OM, Dubey CS, Schmitt AK, Etzel TM. High-Resolution P-T-Time Paths Across Himalayan Faults Exposed Along the Bhagirathi Transect NW India: Implications for the Construction of the Himalayan Orogen and Ongoing Deformation. Geochemistry, Geophys Geosystems. 2020;
Swann PG, Shapiro MA. Regulatory considerations for development of bioanalytical assays for biotechnology products. Bioanalysis. 2011;
Prakash P, Radha, Kumar M, Pundir A, Puri S, Prakash S, et al. Documentation of commonly used ethnoveterinary medicines from wild plants of the high mountains in shimla district, himachal pradesh, india. Horticulturae. 2021;
Yokoyama WM, Christensen M, Santos G Dos, Miller D, Ho J, Wu T, et al. Production of monoclonal antibodies. Curr Protoc Immunol. 2013;
Yamada T. Therapeutic monoclonal antibodies. Keio Journal of Medicine. 2011.
Sharma S, Hussain MS, Agarwal NB, Bhurani D, Khan MA, Ahmad Ansari MA. Efficacy of sirolimus for treatment of autoimmune lymphoproliferative syndrome: a systematic review of open label clinical studies. Expert Opinion on Orphan Drugs. 2021.
Tabrizi M, Bornstein GG, Suria H. Biodistribution mechanisms of therapeutic monoclonal antibodies in health and disease. AAPS Journal. 2010.
van der Kant R, Karow-Zwick AR, Van Durme J, Blech M, Gallardo R, Seeliger D, et al. Prediction and Reduction of the Aggregation of Monoclonal Antibodies. J Mol Biol. 2017;
Downloads
Published
Issue
Section
How to Cite
