EFFICACY OF LUGOL’s IODINE AND GENTAMICIN IN REPEAT BREEDING COWS SUFFERING FROM UTERINE INFECTIONS

Narinder  Singh; Prahlad  Singh; Khushpreet  Singh; Ajeet  Kumar

doi:10.48165/ijar.2023.44.01.8

Authors

Narinder Singh Directorate of Livestock Farms ,Guru Angad Dev Veterinary and Animal Sciences University (GADVASU),Ludhiana - 141 004
Prahlad Singh Department of Teaching Veterinary Clinical Complex ,Guru Angad Dev Veterinary and Animal Sciences University (GADVASU),Ludhiana - 141 004
Khushpreet Singh Department of Teaching Veterinary Clinical Complex ,Guru Angad Dev Veterinary and Animal Sciences University (GADVASU),Ludhiana - 141 004
Ajeet Kumar Department of Veterinary Gynaecology and Obstetrics Guru Angad Dev Veterinary and Animal Sciences University (GADVASU),Ludhiana - 141 004

DOI:

https://doi.org/10.48165/ijar.2023.44.01.8

Keywords:

Cows, Gentamicin, Lugol’s iodine, Repeat breeder, Uterine infections

Abstract

The study was conducted to evaluate the efficacy of Lugol’s iodine (Intrauterine) and gentamicin (parenteral and post-AI) in repeat breeding cows (n=54). Repeat breeding cows were divided into two groups based upon the type of cervico-vaginal mucus (CVM) discharge, Group-1, n=28, repeat breeding cows having pus flakes or pus in uterine discharge; Group-2, n=26, repeat breeding cows having apparently clear CVM. For treatment purpose, 14 cows from Group-1 as Group 1(a) were infused 50 ml of 0.5% lugol solution once on day of estrus and 14 cows as Group 1(b) were injected gentamicin @ 5 mg per kg body weight intra muscular twice daily for three days, starting on the day of estrus. In the Group 2(a), repeat breeding cows (n=15) were infused gentamicin @ 2 mg body weight twenty hours post AI. Group 2(b) comprising of 11 cows served as untreated control. Overall conception rate in Group 1(a) was 72.7% as compared with 60% in Group 1(b) with 1.8 and 2.1 services per conception. Conception rate in repeat breeding cows having apparently normal CVM treated with post AI gentamicin intrauterine infusion didn’t improve as compared to control (40 vs. 36). It was concluded that the intra uterine infusion of lugol’s solution once on day of estrus in repeat breeding cows having purulent vaginal discharge was better in cleaning uterus of uterine infections than parenteral administration of gentamicin for three days

References

Awasthi, M.K. and Nema, R.K. (1995) Comparative efficacy of some broad spectrum antibacterial medicines in repeat

breeder cows under field conditions. Indian J. Anim. Reprod., 103-104.

Awasthi, M.K. and Tiwari, R.P. (1999) Improvement of first ser vice conception rate in crossbred cows. Indian Vet. J., 16: 759-60.

Bhardwaz A., Nema S.P., Mahour S.S., Bagati S. and Kumar, S. (2018). Therapeutic Efficacy of Lugol’s Iodine (I2KI) in Infectious Repeat Breeder Crossbred Cows. Int. J. Curr. Microbiol. App. Sci., 7(12): 648-654.

Carleton, C.L. and Threfall, W.R. (1984) Determination of changes in the rate absorption and histological changes of endometrium following intra-uterine Lugol’s infusion of post-partum cow. Proc Xth Int Congr Anim Repord AI. Urbana Champaign, 111: 412.

Çetin, Y., Gungor, O., Tașal, I., Sİpahİ, C., Șendaq, S., Yildiz, M. and Wehrend, A. (2019) The effects of postpartum routine intrauterine treatments on fertility in cows. Eurasian J. Vet. Sci., 35 (3): 122-130.

Dohmen, M.J.W., Huszenicza, G.Y., Fodor, M., Kulesar, M., Vamos, M., Porkolab, L. Szilagyi, N. and Lohuis, J.A.C.M. (1996). Bacteriology and Fertility in heathy post-partum cow and cows with acute endometritis. Proc. of XIX World Buitrics Congress, Edinburgh, pp. 238-240.

Guedawy, S.A., Neff-Daws, C.A., Davis, L.E. et al (1983) Disposition of gentamicin in the genital tract of cow. J. Vet. Pharmacol. Ther. 6: 85-92

Huszenica, G., Kulesar M., Nagy, P., Milhaly, K., Fekete, S. Zoldag, L. and Trenti, F. (1994). Ovarian and metabolic character istics of repeat breeder cows and geifers and the effect of intrauterine lugol’s treatment on their fertility. Proceedings 18th World Buiatrics Congress, 1: pp.281-288.

Pattnaik, N., Mohanty, B.N., Ray, S.K.H., Mohanty, D.N. and Mishra, P.R. (1992). Clinical report on Lugol’s iodine treat ment of mycotic abortion in bovines. Indian Vet. J., 69: 1029-1039.

Saini, P.S., Grewal, A.S., Nandam A.S. and Arora, A.K. (1995). Intrauterine immunotherapy with immunomodulator lipo polysaccharide (LPS) for bacterial endometritis associated clinical cases of repeat breeders in dairy cattle (Bos taurus x Bos indicus) and buffaloes (Bubalus bubalis). Bull Soc. Fr. Jpn. Sc. Vet. 6: 128-134.

Singh, A., Singh, N., Brar, P.S., Malik, V.S. and Singla, G. (2021). Comparative efficacy of three different fixed timed artifi cial insemination protocols in Sahiwal cows. Indian J. Anim. Reprod., 42 (2): 64-73.

Singh, H., Brar, P.S., Singh, N., Jan, M. H., Honparkhe, M. and Dhindsa, S.S. (2020). Effects of intra-uterine infusion of proteolytic enzymes on selected cytokine concentra tions, uterine inflammation, and fertility in postpartum water buffalo with subclinical endometritis. https://doi. org/10.1016/j.anireprosci.2020.106335

Singh, J., Ghuman, S.P.S., Honparkhe, M. and Singh, N. (2009) Investigations of dominant follicle development, estrus response, ovulation time and fertility in PRID- Treated anestrous buffalo heifers Indian J. Anim. Sci., 79(8): 773

Singh, M., Sharma, A., Kumar, P., Bhardwaj, N., Sharma, A. and Bala, I. (2018) Studies on clinical efficacy of some therapeu tic regimens for the management of endometritis in cows. Explor. Anim. Med. Res., 8(1): 110-112.

Singh, N., Nanda, A. S. and Jagir, S. (2008). Assessment of factors affecting conception rate in crossbred cows following arti ficial insemination under field conditions. Indian J. Anim. Reprod., 29(2): 211-215.

Stolla, R., Hueekmann, Voss. F., Schizer, G., Reibenwein, K., Mytzka, C. (1991) Studies on the aetiology abd treatment of repeat breeding sndromes in cattle. Wiener-Tierarztliche Manatsschrift, 78(10): 337-339.

Yoshida, R., Kitahara, G. and Osawa T. (2020) Intrauterine infu sion of povidone-iodine: Its effect on the endometrium and subsequent fertility in postpartum dairy cows J. Vet. Med. Sci. 82(7): 926–934. doi:10.1292/jvms.20-0165.