Utility of blood smear and bone marrow smear examination in autopsy practice: A preliminary observation
DOI:
https://doi.org/10.48165/Keywords:
autopsy, death, bone marrow, blood smear, diagnosisAbstract
Autopsy diagnosis rests on observation of gross anatomical features, microscopic examination and toxicological analysis. However, certain diseases need additional laboratory procedures for confirming diagnosis or ruling out diagnosis. Examination of blood film and bone marrow smear has considerable diagnostic and therapeutic importance in clinical setup. In the present study we have found encouraging morphologicalfindings in blood and bone marrow smears for arriving at diagnosis in few conditions and the method can be utilized as supplementary laboratory procedure for confirming or ruling out diagnosis.
Downloads
References
1. Gauda HS, Mestri SC. Piecemeal or whole body X ray in firearm injuries – a case report. J Indian Acad Forensic Med 2008;30:231-4.
2. Becker K, Ortmann C, Bajanowski T, Brinkmann B, Peters G. Use of polymerase chain reaction for postmortem diagnosis of malaria. Diagn Mol Pathol 1999; 8: 211-5.
3. Bardale R. Diagnosis of malaria at autopsy: Preliminary observations with immunochromatographic rapid test. J Forensic Med Toxicol 2008; 25: available at www.indianjournals.com
5. Challener RC, Morrissey AM, Jacobs MR. Postmortem diagnosis of meningococcemia by detection of capsular polysaccharides. J Forensic Sci 1988; 33: 336 – 46.
6. Selvanayagam ZE, Gnanavendhan SG, Ganesh KA, Rajagopal D, Rao PV. ELISA for the detection of venoms from four medically important snakes of India. Toxicon 1999; 37: 757 – 70.
7. Schwartz HJ, Squillace DL, Sher TH, Teigland JD, Yunginger JW. Studies in stinging insect hypersensitivity: postmortem demonstration of antivenom IgE antibody in possible sting-related sudden death. Am J Clin Pathol 1986; 85: 607 – 10.
8. Robert V, Stewart MD. Postmortem diagnosis of myocardial disease by enzyme analysis of pericardial fluid. Am J Clin Pathol 1984; 82: 411 – 7.
9. Luna A, Carmona A, Villanueva E. The postmortem determination of CK isoenzymes in the pericardial fluid in various causes of death. Forensic Sci Int 1983; 22: 23 – 30.
10. Luna A, Gomez Zapata M, Vicente V, Osuna E. A cytologic study of the sediments in pericardial fluid as it relates to a diagnosis of the mechanism of death. Z. Rechtsmed 1987;99:129-34.
11. Shah VB, Deokar MS, Modi CJ, Lad S, Rupani AB, Meenakshi B. The different facets of haemolymphatic malignancies – an autopsy study of 10 cases. Bombay Hosp J 2008;50:566-71.
12. Ost A, Nilsson-Ardnor S, Henter JI. Autopsy findings in 27 children with haemphagocytic lymphohistiocytosis. Histopathology 1998;32:310-16.
13. Babapulle CJ, Jayasundera NPK. Cellular changes and time since death. Med Sci Law 1993;33:213-22.
14. Penttila A, Laiho K. Autolytic changes in blood cells of human cadavers II. Morphological studies. Forensic Sci Int 1981;17:121-32.
15. Bardale R, Dixit PG. Evaluation of morphological changes in blood cells of human cadaver for the estimation of postmortem interval. Medicolegal Update 2007;7:35-9.
16. Laiho K, Penttila A. Autolytic changes in blood cells and other tissue cells of human cadavers. 1. Viability and ion studies. Forensic Sci Int 1981;17:109-20.
17. Firkin F, Chesterman C, Penington D, Rush B (eds). Pancytopenia and aplastic anemia. In: de Gruchy’s Clinical Hematology in Medical Practice. 5th ed 1989. Blackwell Science Ltd. 119-36.