Seromycin, an Effective Treatment for Tuberculosis in Tamsk, Russia
DOI:
https://doi.org/10.48165/Keywords:
Seromycin, Tuberculosis, Sensitivity, Colonies, RussiaAbstract
This study was conducted to determine the minimum inhibitory concentration of cycloserine on 6 isolates of tuberculosis from Tomsk, Russia. Using the broth microdilution (BM) method, the isolates were found to be sensitive to 32 μg/ml of seromycin after 3 weeks of treatment. These results conformed to the control strain, irrespective of the amount of inoculum used. There was an indirect relationship between the amount of culture treated and the MIC of seromycin. All this show that seromycin was an effective treatment for tuberculosis in Tomsk, Russia.
References
. Anon. (1965). Acute poisoning by cycloserine. Brit Med J. 1, 907- 908.
. Petrini B and Hoffner S. (1999). Drug resistant and multidrug resistant tubercle bacilli. Int J Antimicrobial Agents. 13, 93-97.
. Sharma SK and Mohan A. (2007). The implications of multidrug – resistant tuberculosis. Bact Infect. 52-54.
. Singh R. (2011). Mycobacterium tuberculosis: Telling a story of truths. J Pure Appl Microbiol. 5 (2), 541-544.
. Singh R. (2012). A biochemical and microbiological appraisal on the stability of the second-line anti-tuberculosis drug, cycloserine in Mycobacterium tuberculosis. J Pure Appl Microbiol. 6 (1), 209-211.
. Singh R. (2013). Minimum inhibitory concentration: Interpretation and cross-sectional analysis in an unstandardised 7H9 Mycobacterium tuberculosis
broth-based system – A hypothetical case. J Pure Appl Microbiol 7 (1), 777-784.
. Todar. (2011). Todar’s Textbook of Bacteriology: Tuberculosis. Madison Wisconson, USA. http://textbook/bacteriology.net/t
uberculosis.html. Accessed: 17 November 2011.
. WHO. (2012). A practical handbook on the pharmacovigilance of medicines used in the treatment of tuberculosis: enhancing the safety of the TB patient. Geneva Switzerland. WHO, Geneva, Switzerland.
. Zhang Y and Amzel LM. (2002). Tuberculosis drug targets. Curr Drug Targ 3, 131-151.