Antidiabetic Efficacy of Citrullus colocynthis and Citrullus lanatus: A Review

Authors

  • Aderiike Adewumi Department of Basic Science, School of Sciences and Technology, Babcock University, Ilishan-Remo, Ogun State, Nigeria
  • Rufus Animashaun Department of Basic Science, School of Sciences and Technology, Babcock University, Ilishan-Remo, Ogun State, Nigeria
  • Oluwapelumi Micheal Ajiboye Department of Basic Science, School of Sciences and Technology, Babcock University, Ilishan-Remo, Ogun State, Nigeria
  • Kayode Olusola Ogunwenmo Department of Basic Science, School of Sciences and Technology, Babcock University, Ilishan-Remo, Ogun State, Nigeria

DOI:

https://doi.org/10.48165/bpas.2023.39.1.6%20

Keywords:

Anti-inflammatory, Antioxidant, Hypoglycemic, Cucurbitacins, Flavonoids, Alkaloids

Abstract

The present review is focused on the anti-diabetic potential of  Citrullus colocynthis and Citrullus lanatus, commonly referred to as  bitter apple and watermelon, respectively. The plants have a history of  being employed for therapeutic uses and recent investigation has  revealed their potential as antidiabetic agents owing to the presence of  bioactive compounds, including cucurbitacins, flavonoids, and  alkaloids. The present study examines the therapeutic potential of the  plants, highlighting their antidiabetic, anti-inflammatory,  antioxidant, and hypoglycemic properties. Additionally, the  mechanisms responsible for the antidiabetic effects of these  substances, and their effectiveness in the treatment of diabetes in  animal and human subject. In addition to safety and toxicity,  potential adverse effects were also discussed. In conclusion, these  plants possess considerable potential as alternative therapies for  diabetes. However, additional investigation is required to extensively  comprehend their therapeutic efficacy and establish appropriate and  safe dosages for clinical application. 

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Published

2023-06-19

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Vol. 39 No. 1 (2023): Bio-Science Research Bulletin (Jan-Jun) 2023

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Articles

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Antidiabetic Efficacy of Citrullus colocynthis and Citrullus lanatus: A Review . (2023). Bio Science Research Bulletin, 39(1), 39–51. https://doi.org/10.48165/bpas.2023.39.1.6