Effect of Actinomycin and 5-fluorouracil on Acid Phosphatase Activity of Gill, Gonad, Digestive Gland, and Foot Tissues of Fresh Water Bivalve, Lamellidens Marginalis (lamark)
DOI:
https://doi.org/10.48165/bpas.2023.39.1.1%20Keywords:
Anticancer drugs, Acid phosphatase, Cytotoxicity, BivalvesAbstract
Actinomycin and 5-Fluorouracil are potent and effective anticancer drugs commonly used for chemotherapy against solid tumors. These drugs show effective chemoprevention in chemotherapy and also lead to several manipulations and cytotoxicity in tissues. In present studies, sub-lethal doses of Actinomycin and 5- fluorouracil (LC50/10 for 96 hours) were given to fresh water bivalves, Lamellidens Marginalis. For 45 days. The acid phosphatase activities were determined from different tissues of control and experimental bivalves by method of Gutman and Gutman. It was found that acid phosphatase activities were increased in different tissues with increased period of exposure to anticancer drugs in experimental bivalves. It was also observed that acid phosphatase activity increased in different tissues were found to be more in Actinomycin treated bivalves than that of 5- fluorouracil treated bivalves.
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