Effect of Actinomycin and 5-fluorouracil on Acid Phosphatase Activity of Gill, Gonad, Digestive Gland, and Foot Tissues of Fresh Water Bivalve, Lamellidens Marginalis (lamark)

Authors

  • P A Bhosale Department of Zoology, Sundarrao More Arts, Commerce, and Science (Sr.) College, Poladpur, Tal- Poladpur Dist- Raigad, Maharashtra 402303, India

DOI:

https://doi.org/10.48165/bpas.2023.39.1.1%20

Keywords:

Anticancer drugs, Acid phosphatase, Cytotoxicity, Bivalves

Abstract

Actinomycin and 5-Fluorouracil are potent and effective anticancer  drugs commonly used for chemotherapy against solid tumors. These  drugs show effective chemoprevention in chemotherapy and also lead  to several manipulations and cytotoxicity in tissues. In present  studies, sub-lethal doses of Actinomycin and 5- fluorouracil (LC50/10  for 96 hours) were given to fresh water bivalves, Lamellidens  Marginalis. For 45 days. The acid phosphatase activities were  determined from different tissues of control and experimental bivalves  by method of Gutman and Gutman. It was found that acid  phosphatase activities were increased in different tissues with  increased period of exposure to anticancer drugs in experimental  bivalves. It was also observed that acid phosphatase activity increased  in different tissues were found to be more in Actinomycin treated  bivalves than that of 5- fluorouracil treated bivalves.  

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Published

2023-06-19

Issue

Vol. 39 No. 1 (2023): Bio-Science Research Bulletin (Jan-Jun) 2023

Section

Articles

How to Cite

Effect of Actinomycin and 5-fluorouracil on Acid Phosphatase Activity of Gill, Gonad, Digestive Gland, and Foot Tissues of Fresh Water Bivalve, Lamellidens Marginalis (lamark) . (2023). Bio Science Research Bulletin, 39(1), 1–6. https://doi.org/10.48165/bpas.2023.39.1.1