Prevalence of Inducible Clindamycin Resistance in Methicillin Resistant Staphylococcus aureus Isolated from Different Clinical Samples Received in a Tertiary Care Hospital

Authors

  • Pawan Kumar Prajapati Department of Biotechnology, Maharishi Markandeshwar (Deemed to be University), Mullana-Ambala (HR) - 133207, India
  • Diwakar AggarwaL Department of Biotechnology, Maharishi Markandeshwar (Deemed to be University), Mullana-Ambala (HR) - 133207, India
  • Sushil Kumar Upadhyay Assistant Professor, Department of Biotechnology, Maharishi Markandeshwar (Deemed to be University), Mullana-Ambala (Haryana) - 133207, India.
  • Hardeep Singh Tuli Department of Biotechnology, Maharishi Markandeshwar (Deemed to be University), Mullana-Ambala (HR) - 133207, India
  • Mukesh Yadav Department of Biotechnology, Maharishi Markandeshwar (Deemed to be University), Mullana-Ambala (HR) - 133207, India
  • Anil K Sharma Department of Biotechnology, Maharishi Markandeshwar (Deemed to be University), Mullana-Ambala (HR) - 133207, India

DOI:

https://doi.org/10.48165/

Keywords:

Staphylococcus aureus, MRSA, Catheter, D test, Clindamycin

Abstract

Staphylococcus aureus is recognized as greatest concern  associated with both hospital and community  acquired infections and if it is methicillin resistant  then the severity increases. Erythromycin and  clindamycin are considered as treatment of decision.  However, protection from erythromycin with phony  susceptibility to clindamycin in vitro may prompt  remedial disappointment. Hence it is mandatory to  study the prevalence of inducible clindamycin  resistance. Out of the 875 clinical isolated samples, 403  (46.05%) showed presence of S. aureus. Out of theses  403 samples, 297 (73.70%) were found to be  methicillin resistant S. aureus (MRSA) and 106 (26.30  %) were found to be methicillin sensitive S. aureus  (MSSA). Further MRSA (Methicillin Resistant S.  aureus) samples were analyzed for erythromycin and  clindamycin sensitivity and resistivity. Minimum  Inhibitory Concentration (MIC) of clindamycin among  D test (Disc test) positive MRSA was also analyzed.  The occurrence rate of D test positive MRSA strain  was found to be more in Hospital Acquired Infections  (HAI) as compared with Community Acquired  Infection (CAI). Frequency of D test positive MRSA  strains were more in Pus samples as compared with  urine and blood samples. Further in case of HAI, D  test positive MRSA was predominantly found in  patients with Diabetic foot patients with postoperative  wound and patients with Necrotizing Fasciitis. Out of  samples associated with uropathogenic infection in  hospital settings, More D test positive MRSA were  found to be associated in patients with catheter  installation in without catheter installation. Prolonged  hospital stay (>5 days) was observed to be major risk  factor for D test positive MRSA. Demographic profile  of patients with D test positive MRSA strains revealed  the predominance of male in comparison to female.  

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Published

2020-10-15

Issue

Vol. 39 No. 2 (2020): Bulletin of Pure and Applied Sciences Zoology (Jul-Dec) 2020

Section

Articles

How to Cite

Prevalence of Inducible Clindamycin Resistance in Methicillin Resistant Staphylococcus aureus Isolated from Different Clinical Samples Received in a Tertiary Care Hospital . (2020). Bulletin of Pure & Applied Sciences- Zoology , 39(2), 344–353. https://doi.org/10.48165/