Immunoinformatic Approach for Development of Synthetic Peptide Vaccine from Translationally Controlled Tumor Protein of Brugia malayi

Authors

  • Somnath Balbhim Waghmare Assistant Professor, Department of Zoology Nowrosjee Wadia College, Pune, Maharashtra 411001, India

DOI:

https://doi.org/10.48165/

Keywords:

Translationally controlled tumor protein, Brugia malay, MHC, Antigenicity, Vaccine

Abstract

Lymphatic filariasis affects over 120 milliopeople in 72 countries throughout the tropics and  sub-tropics of Asia and other parts of the world. Brugiamalayi is a gonochoristic (male-female)  filarial parasite of medical attention and is  phylogenetically representative of other  infectious nematodes. One of the appealing and  importantdrugtargetsagainstthepopulationisTranslationally controlled  tumor protein of Brugia malayi as these proteins  play important role in various developmental  stages of nematode. The MHC molecules are cell  surface proteins, which contributes significantly  in host immune responses and contribution of  MHC class in response to nearly all antigens and  it give effects on precise sites. Projected MHC  binding areasturns like red flags which are  antigen specific and produce immune response against the parent antigen. Therefore, a minor  fragment of antigen can make immune response  against the entire antigen. This theme is applied  in designing a subunit and synthetic peptide  vaccines against filarial nematode Brugia malayi.  In current study, we analysed translationally  controlled tumor protein of Brugia malayi and  these predicted antigenic epitopes shows a very  potential drug targets to identify active sites of  proteins, which form antibodies against  infestation.  

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Published

2020-06-16

Issue

Vol. 39 No. 1 (2020): Bulletin of Pure and Applied Sciences Zoology (Jan-Jun) 2020

Section

Articles

How to Cite

Immunoinformatic Approach for Development of Synthetic Peptide Vaccine from Translationally Controlled Tumor Protein of Brugia malayi . (2020). Bulletin of Pure & Applied Sciences- Zoology , 39(1), 143–151. https://doi.org/10.48165/