Immunoinformatic Approach for Development of Synthetic Peptide Vaccine from Translationally Controlled Tumor Protein of Brugia malayi
DOI:
https://doi.org/10.48165/Keywords:
Translationally controlled tumor protein, Brugia malay, MHC, Antigenicity, VaccineAbstract
Lymphatic filariasis affects over 120 milliopeople in 72 countries throughout the tropics and sub-tropics of Asia and other parts of the world. Brugiamalayi is a gonochoristic (male-female) filarial parasite of medical attention and is phylogenetically representative of other infectious nematodes. One of the appealing and importantdrugtargetsagainstthepopulationisTranslationally controlled tumor protein of Brugia malayi as these proteins play important role in various developmental stages of nematode. The MHC molecules are cell surface proteins, which contributes significantly in host immune responses and contribution of MHC class in response to nearly all antigens and it give effects on precise sites. Projected MHC binding areasturns like red flags which are antigen specific and produce immune response against the parent antigen. Therefore, a minor fragment of antigen can make immune response against the entire antigen. This theme is applied in designing a subunit and synthetic peptide vaccines against filarial nematode Brugia malayi. In current study, we analysed translationally controlled tumor protein of Brugia malayi and these predicted antigenic epitopes shows a very potential drug targets to identify active sites of proteins, which form antibodies against infestation.
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