A Comparative Hepatoprotective Effect of Liraglutide and Nano Extracts of Ficus carica and Olea europaea Leaves on Diabetes-Induced in Laboratory Animals

Authors

  • Laila A Hummdi University of Jeddah, Department of Biology, Jeddah, Saudi Arabia, Box # 21959 Jeddah.
  • Safa H Qahl University of Jeddah, Department of Biology, Jeddah, Saudi Arabia, Box # 21959 Jeddah.

DOI:

https://doi.org/10.48165/

Keywords:

Liraglutide, diabetic ratsmodel, hepatoxicity, ficuscarica, olea europaea

Abstract

Effects of Liraglutide and nano extracts of ficus  carica and Olea europaea leaves (NEML) on liver  were investigatedin type 2 diabetes mellitus  (T2DM) rats' model. Forty male albino Wistar  rats were used in this experimental study. Thirty  rats were injected intraperitoneal (i.p.) with STZ  single dose (60 mg/kg) to induce T2DM and  assigned into groups (2, 3 & 4). Ten rats served as  negative control (group 1, NDC). Group (2) rats  served as positive control (DC), group (3) (LD)  received Liraglutide subcutaneous injected (0.2  mg/kg/day) for 8 weeks; group (4) (NEML)  received orally NEML (45X107 ng  /250gb.w./day) for eight weeks. After eight  weeks, rats were killed and blood collected for  assessment of liver functions. Liver were  harvested for histopathological examination.  Results showed significantly elevated serum  levels of alanine amino transferase (ALT),  alkaline phosphatase (ALP), aspartate amino  transferase (AST), and gamma glutamyl  transpeptidase (GGT) in groups (2) indicative of  hepatocellular damage. Histopathological liver  examination revealed marked hepatic  degeneration characterized by vascular  congestion and degeneration of endothelial  lining, cellular infiltration, sinusoidal dilatation,  hydropic degeneration, focal necrosis, nuclear  pleomorphism, and loss of kupffer and  endothelial cells lining blood sinusoids, bile duct  proliferation compared to control group.  Alterations of liver functions and hepatocytes  lesions were significantly reduced with  Liraglutide (group 3) and nano extracts of NEML  (group 4). In conclusion, treatment with  Liraglutide and nano extract of NEML leaves  restored altered parameters in liver enzymes  towards normal, and nano extract of NEML  leaves exhibited better hepatoprotective  properties against diabetic-induced  hepatocellular damage than Liraglutide.

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Published

2020-05-15

Issue

Vol. 39 No. 1 (2020): Bulletin of Pure and Applied Sciences Zoology (Jan-Jun) 2020

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Articles

How to Cite

A Comparative Hepatoprotective Effect of Liraglutide and Nano Extracts of Ficus carica and Olea europaea Leaves on Diabetes-Induced in Laboratory Animals . (2020). Bulletin of Pure & Applied Sciences- Zoology , 39(1), 62–74. https://doi.org/10.48165/