Hyperleptinemia is correlated with Metabolic Syndrome Risk Factors in Women with Polycystic Ovarian Syndrome

Authors

  • Zeinab Naghshband PhD Research Scholar, Department of Studies in Zoology, University of Mysore, Manasagangothri, Mysuru, Karnataka 570006, India
  • Suttur S Malini Professor and Chairperson, Department of Studies in Zoology, University of Mysore, Manasagangothri, Mysuru, Karnataka 570006, India

DOI:

https://doi.org/10.48165/

Keywords:

Polycystic Ovary Syndrome, LeptinSerum, Metabolic Syndrome, Anthropometric Indices, Endocrine Parameters

Abstract

Polycystic ovarian syndrome (PCOS) as a common cause of  anovulatory, is associated with glucose metabolic  abnormality, hyperinsulinemia and obesity, features which  are related to leptin and its receptors. However, there is still  debate over the link between leptin and endocrine and  metabolic factors in PCOS. The present study aim to  compare both obese/overweight and normal/underweight PCOS and healthy women regarding anthropometric and  endocrine parameters. Also, estimate inter-relationship of  serum leptin levels with anthropometric and endocrine  parameters. This is a case-control study including 150  PCOS women and 100 control subjects. Anthropometric  indices were measured for each subject. Lipid profile,  fasting glucose, insulin, gonadotropin hormones,  testosterone and serum leptin were estimated. Insulin  resistance through HOMA-IR model and insulin  sensitivity through (QUICKI) were calculated. Student’s  t-test and two-way ANOVA were used for analyzing the  differences between groups. Pearson (r) correlation  coefficient was used to assess the correlation between serum  leptin and the independent variables. Waist circumference  was increased in normal/underweight PCOS group  compared to normal/underweight control group. Fasting  glucose and insulin, HOMA-IR, QUICKI and serum leptin levels were significantly increased in obese/overweight  PCOS group compared to obese/overweight control group.  Strong significant correlation was observed between serum  leptin levels and increased BMI, LDL, fasting glucose,  fasting insulin, HOMA-IR and hypotension. Serum leptin  levels showed strong correlation with metabolic syndrome  risk factors especially glucose metabolic abnormality in  PCOS women compared to control. 

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Published

2021-12-15

Issue

Vol. 40 No. 2 (2021): Bulletin of Pure and Applied Sciences Zoology (Jul-Dec) 2021

Section

Articles

How to Cite

Hyperleptinemia is correlated with Metabolic Syndrome Risk Factors in Women with Polycystic Ovarian Syndrome . (2021). Bulletin of Pure & Applied Sciences- Zoology , 40(2), 324–333. https://doi.org/10.48165/