Wnt, BMP and Sox Mediated Gene Dysregulationvia Endocrine Disrupting Chemicals BPA and BPS; Studies in Neurogenesis and Alteration in Brain Activity: A Review

Authors

  • Swati Jain Research Scholar (ICMR SRF), Department of Zoology, Dr. Harisingh Gour Vishwavidyalaya (A Central University), Sagar, Madhya Pradesh 470003, India.
  • Abhishek Jain Research Scholar, Department of Biotechnology, Dr. Harisingh Gour Vishwavidyalaya (A Central University), Sagar, Madhya Pradesh 470003, India.
  • Roshni Jain Research Scholar, Department of Biotechnology, Dr. Harisingh Gour Vishwavidyalaya (A Central University), Sagar, Madhya Pradesh 470003, India.
  • Swati Singh Thakur Research Scholar, Department of Biotechnology, Dr. Harisingh Gour Vishwavidyalaya (A Central University), Sagar, Madhya Pradesh 470003, India.
  • Subodh Kumar Jain Professor, Department of Zoology, Dr. Harisingh Gour Vishwavidyalaya (A Central University), Sagar, Madhya Pradesh 470003, India

DOI:

https://doi.org/10.48165/

Keywords:

EDC, Bisphenol (BPA & BPS), Neurogenesis, Wnt, BMP, Sox

Abstract

Endocrine disrupting chemicals (EDC) are those  compounds that can interrupt the biosynthesis,  metabolism, and functioning of endogenous  hormones. Bisphenol A and S are well-known EDCs  that can mimic an endogenous hormone estrogen.  Both the chemicals have been detected in  commercially available food products as used in  polycarbonate plastic bags or within canned linings.  BPS is more likely to accumulate in the aquatic  environment or in the food chain; also detected in  human samples. Due to its estrogen-like activity, it is  able to interfere with the processes of growth and  development such as reproductive development, bone  development and soon. One such process that can be  altered by BPA is neurogenesis. Neurogenesis  continues to occur in adults in a limited fashion which  is enabled by the action of genes involved ingrowth  and development such as, Wnt3a, BMP2 and Sox2.  Wnt3a promotes neurogenesis while BMP2 represses  the neurogenesis but also promotes the fate  specification and survival of neuroblasts, andSox2 is  responsible for themaintenance of quiescent neural  stem cells (NSCs), these genes together act to enable  neurogenesis in a controlled manner.BPA and BPS  have the potential to disturb neuron expressions as  well as their fate, as it is directly linked with the  nervous system. This review dealt the effect of EDCs,  BPA and BPS in neurogenesis, via exogenous and  endogenous factors thereby, aid in understanding the  basic cross-talk among these pathways during  neuronal development and dysregulation.  

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Published

2022-06-15

Issue

Vol. 41 No. 1 (2022): Bulletin of Pure and Applied Sciences-Zoology (Jan-Jun) 2022

Section

Articles

How to Cite

Wnt, BMP and Sox Mediated Gene Dysregulationvia Endocrine Disrupting Chemicals BPA and BPS; Studies in Neurogenesis and Alteration in Brain Activity: A Review . (2022). Bulletin of Pure & Applied Sciences- Zoology , 41(1), 158–168. https://doi.org/10.48165/