Oxidative Stress in Plasmodium: Role of Glutathione Revisited

Authors

  • Gaurav Kapoor Department of Zoology, Rajkiya Kanaya Mahavidalaya (RKMV), Shimla-171001, Himachal Pradesh, India.

DOI:

https://doi.org/10.48165/

Keywords:

Malaria, Plasmodium, Glutathione, Antioxidant, Oxidative stress

Abstract

Malaria is still one of the three leading infectious disease  in the world. Plasmodium, unicellular eukaryotic parasite  responsible for the disease is under immense oxidative  stress during the erythrocytic stages of its life cycle. The  parasite overcomes the oxidative stress generated  endogenously and by host immune system through its  antioxidant and redox systems. Plasmodium possesses  glutathione and thioredoxin redox systems with  overlapping but distinct functions that help it to maintain  redox state. Glutathione is the most abundant low  molecular weight thiol redox buffer in all living cells that  is detrimental for the maintenance of intracellular redox  status. Glutathione functions as an antioxidant protecting  cells against the deleterious effects of oxidant free  radicals and also in detoxification process reactions in  parasite. Interfering with glutathione redox system of  parasite can be a novel way to combat the disease. The  present review describes the recent findings in role and  mechanism of glutathione in maintaining the redox status  during oxidative stress in infection with Plasmodium 

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Published

2022-06-15

Issue

Vol. 41 No. 1 (2022): Bulletin of Pure and Applied Sciences-Zoology (Jan-Jun) 2022

Section

Articles

How to Cite

Oxidative Stress in Plasmodium: Role of Glutathione Revisited . (2022). Bulletin of Pure & Applied Sciences- Zoology , 41(1), 149–157. https://doi.org/10.48165/