Study of the Effect of Hypothyroidism and Thyrotoxicosis on the Proliferative Activity of the Red Bone Marrow in Experimental Animals with an Implanted Akatol Tumor

Abstract

Analysis of the morphological structure of histological  preparations of the thymus of experimental animals  showed that experimental hypothyroidism leads to  significant rearrangements both in the cellular  composition and in the structure of the organ. The  absolute area of the cortical zone, in comparison with  the control group, significantly decreases, signs of  hypertrophy of epithelial cells and an increase in the  intensity of intracellular differentiation processes are  revealed. There is little or no tissue proliferation. The  proportion of lymphocytes in the cortical zone is  65.26±1.50%, the proportion of epithelial cells is  2.1±0.45%, which is significantly lower than those in  the control group IV–81.45±1.22% and 4.2±0.63%,  respectively. There are areas of rarefaction and  degradation of the thymus tissue, which demonstrates  the high rate of involutional processes. The thymus  sharply decreased in size relative to the control and  was represented by two small lobes and fragments, or  was divided into separate segments, often of an  irregular shape.