Does Time restriction feeding reverse the High fat diet induced obesity in Drosophila melanogaster?

Authors

  • Mohammad S Al-Maqashah Ph.D. Research Scholar, Chronobiology lab, Department of Studies in Zoology, Manasagangothri, University of Mysore, Mysuru, Karnataka 570005, India.
  • V Shakunthala Associate Professor, Department of Studies in Zoology, Manasagangothri, University of Mysore, Mysuru, Karnataka 570005, India.
  • C S Damini Ph.D. Research Scholar, Chronobiology lab, Department of Studies in Zoology, Manasagangothri, University of Mysore, Mysuru, Karnataka 570005, India.

DOI:

https://doi.org/10.48165/

Keywords:

Drosophila melanogaster, TRF, HFD, SOD, catalase

Abstract

Obesity and its co-morbidity are the most challenging  tasks for the current health care system. It is a  multifactorial disorder either due to genetic  predisposition, high calorie-dense diet, circadian  disruption, etc. Circadian disruption is due to  people’s altered lifestyle choices have resulted in  increased obesity that can be measured in terms of  lipid profiles, overweight, and endogenous  antioxidant level. As consequence of this increased  diabetes and cardiovascular problems among the  current generation. The present study is an attempt to  understand the importance of disciplined lifestyle and eating at the right time. Many studies in this regard  have revealed time-restriction feeding and its benefits.  The current study aims to investigate the adverse  effects of a high-fat diet on odd-time eating and high fat diet with that of time-restriction feeding (TRF). To  address this problem, we choose Drosophila  melanogaster flies that were fed with different food  regime as high-fat diet (HFD), a normal diet (ND) as a  control, HFD+TRF and ND+TRF. The biochemical  assays were used to detect obesity, the stress and TRF  normalizes the triglyceride level to reduce  endogenous antioxidants in the HFD group was  observed and TRF has an effective response to obesity  by reducing body adiposity caused by a high-fat diet. 

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Published

2022-06-15

Issue

Vol. 41 No. 1 (2022): Bulletin of Pure and Applied Sciences-Zoology (Jan-Jun) 2022

Section

Articles

How to Cite

Does Time restriction feeding reverse the High fat diet induced obesity in Drosophila melanogaster? . (2022). Bulletin of Pure & Applied Sciences- Zoology , 41(1), 56–66. https://doi.org/10.48165/