Screening of Spider Venom Peptides and Molecular Docking of FLT3 and LCK
DOI:
https://doi.org/10.48165/bpas.2023.42A.1.13Keywords:
Anticancer Peptides, Chemotherapy, Spider VenomAbstract
The drawbacks of traditional chemotherapy include its inability to dissolve in water, lack of selectivity, and multidrug resistance. The use of anticancer peptides is a unique therapeutic approach against cancer cells. In this In-silico work, the kinase inhibition activity for both chosen target molecules (Flt3 and Lck protein) was evaluated in order to find a possible anti-leukemic spider venom peptide. Out of the 11 spider venom peptides, Lycosin-I peptide (from Lycosa singoriensis) for Lck and Latarcin 2a peptide (from Lachesana tarabaevi) for Flt3 were suggested as the best lead peptides for the creation of anti-leukemic drugs.
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