Screening of Spider Venom Peptides and Molecular Docking of FLT3 and LCK

Authors

  • Durgesh M Agase Assistant Professor, Department of Zoology, Govt Jatashankar Trivedi College, Balaghat, Madhya Pradesh 481101, India

DOI:

https://doi.org/10.48165/bpas.2023.42A.1.13

Keywords:

Anticancer Peptides, Chemotherapy, Spider Venom

Abstract

The drawbacks of traditional chemotherapy include its  inability to dissolve in water, lack of selectivity, and  multidrug resistance. The use of anticancer peptides is a  unique therapeutic approach against cancer cells. In this  In-silico work, the kinase inhibition activity for both  chosen target molecules (Flt3 and Lck protein) was  evaluated in order to find a possible anti-leukemic spider  venom peptide. Out of the 11 spider venom peptides,  Lycosin-I peptide (from Lycosa singoriensis) for Lck and  Latarcin 2a peptide (from Lachesana tarabaevi) for Flt3  were suggested as the best lead peptides for the creation  of anti-leukemic drugs. 

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Published

2023-06-16

Issue

Vol. 42 No. 1 (2023): Bulletin of Pure and Applied Sciences-Zoology (Jan-Jun) 2023

Section

Articles

How to Cite

Screening of Spider Venom Peptides and Molecular Docking of FLT3 and LCK . (2023). Bulletin of Pure & Applied Sciences- Zoology , 42(1), 149–156. https://doi.org/10.48165/bpas.2023.42A.1.13