Effect of Diclofenac Sodium in Developing Chick Embryo, Gallus Gallus domesticus (Linn, 1758)

Authors

  • Samir Terdalkar Assistant Professor, Department of Zoology, Fergusson College (Autonomous), Pune, Maharashtra 411004, India

DOI:

https://doi.org/10.48165/bpas.2023.42A.1.11

Keywords:

NSAID, Diclofenac Sodium, Toxicity, Embryology, Non Steroidal Anti-Inflammatory Drug

Abstract

Diclofenac sodium, a non steroidal anti-inflammatory  drug (NSAID) is an acetic acid derivative with generic  name Diclofenac. NSAIDs represent some of the oldest  medicines with recorded history of use of people.  However, it is also known to inhibit implantation and  embryonic development in rats and mammals. It is  widely prescribed in India to women of child bearing  age for the treatment of various conditions including  arthritis, masculo-skeletal pain etc. Research has shown  that it also crosses human placenta readily and  potentially teratogenic. The present study focuses on  assessing the embryonic development in chick under  varied dosages of diclofenac sodium at different  developmental stages. The results showed teratogenic  effects such as omphlaocoele, reduced body size, delay  in hatchability and angiogenesis with irregular  heartbeats.  

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Published

2023-06-16

Issue

Vol. 42 No. 1 (2023): Bulletin of Pure and Applied Sciences-Zoology (Jan-Jun) 2023

Section

Articles

How to Cite

Effect of Diclofenac Sodium in Developing Chick Embryo, Gallus Gallus domesticus (Linn, 1758) . (2023). Bulletin of Pure & Applied Sciences- Zoology , 42(1), 134–139. https://doi.org/10.48165/bpas.2023.42A.1.11