Saliva: An Emerging Adjunct Biomarker for Psoriasis –Trends, Scope and Relevance
DOI:
https://doi.org/10.48165/bpas.2023.42A.2.12Keywords:
Psoriasis, Saliva, BiomarkerAbstract
Psoriasis is a widely prevalent chronic immuno inflammatory dermatological disease resulting from a complex and dynamic interplay of genetic, environmental, and immunological aetiologies. It manifests as characteristic erythematous psoriatic plaques visible to the naked eye, but prognostic biomarkers for disease monitoring and therapeutic effectiveness are still absent. Saliva is a biological fluid that, besides being critical to maintaining oral homeostasis, harbors various salivary microbiota and inflammatory markers. It can be easily collected, stored, and analyzed. Oral fluids offer an excellent advantage for biomarker study as they are non-invasive and fast techniques. Studies showed that the saliva of healthy individuals and those with psoriasis had differences in the levels of inflammatory cytokines, immunoglobulin A, and anti-oxidant biomarkers. In GCF, individuals with psoriasis showed higher levels of S100A8, IL-18, and sE-selectin than healthy individuals, independent of periodontal status. Oxidative stress(OS) is one of the pathogenetic factors of psoriasis. Thus levels of ROS and anti-oxidants can also become important factors in diagnosis.
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Asa’ad, F., Fiore, M., Alfieri, A., Pigatto, P. D. M., Franchi, C., Berti, E., ... & Damiani, G. (2018). Saliva as a future field in psoriasis research. BioMed research international, 2018.
Belstrøm, D., Eiberg, J. M., Enevold, C., Grande, M. A., Jensen, C. A. J., Skov, L., & Hansen, P. R. (2020). Salivary microbiota and inflammation-related proteins in patients with psoriasis. Oral Diseases, 26(3), 677-687.
Boehncke, W. H., & Brembilla, N. C. (2022). Pathogenesis-oriented therapy of psoriasis using biologics. Expert Opinion on Biological Therapy, 22(12), 1463-1473.
Brüne, B., & Lapetina, E. G. (1989). Activation of a cytosolic ADP ribosyltransferase by nitric oxide-generating agents. Journal of Biological Chemistry, 264(15), 8455-8458.
da Silva, J. B., de Carvalho, A. E. V., Schneider, C., & Corbellini, V. A. (2022). Saliva may predict quality of life in psoriasis as measured by Fourier transform infrared spectroscopy (FTIR) and chemometrics. Photodiagnosis and Photodynamic Therapy, 39 , 103017.
De La Cal, C., Lomniczi, A., Mohn, C. E., De Laurentiis, A., Casal, M., Chiarenza, A., ... & Elverdín, J. C. (2006). Decrease in salivary secretion by radiation mediated by nitric oxide and prostaglandins Neuroimmune
modulation, 13(1), 19-27.
Del Castillo Carrillo, L. F., Schwarz, W., & Hornstein, O. P. (1981). Immunoglobulins in serum, whole saliva, and parotid saliva of
male healthy and psoriatic individuals. Archives of Dermatological Research, 271, 63-71.
Dilek, N., Dilek, A. R., Taşkın, Y., Erkinüresin, T., Yalçın, Ö., & Saral, Y. (2016). Contribution of myeloperoxidase and inducible nitric oxide synthase to pathogenesis of psoriasis. Advances in Dermatology and Allergology/Postępy Dermatologii i Alergologii, 33(6), 435-439.
Gaffen, S. L., Jain, R., Garg, A. V., & Cua, D. J. (2014). The IL-23–IL-17 immune axis: from mechanisms to therapeutic testing. Nature reviews immunology, 14(9), 585-600.
Ganzetti, G., Campanati, A., Santarelli, A., Sartini, D., Molinelli, E., Brisigotti, V., ... & Offidani, A. (2016). Salivary interleukin-1β: Oral inflammatory biomarker in patients with psoriasis. Journal of International Medical Research, 44(1_suppl), 10-14.
Gasior-Chrzan, B., & Falk, E. S. (1992). Lysozyme and IgA concentrations in serum and saliva from psoriatic patients. Acta dermato-venereologica, 72(2), 138-140.
Grozdev, I., Korman, N., & Tsankov, N. (2014). Psoriasis as a systemic disease. Clinics in dermatology, 32(3), 343- 350.
Jiménez, C., Bordagaray, M. J., Villarroel, J. L., Flores, T., Benadof, D., Fernández, A., & Valenzuela, F. (2022). Biomarkers in oral fluids as diagnostic tool for psoriasis. Life, 12(4), 501.
Kadam, D. P., Suryakar, A. N., Ankush, R. D., Kadam, C. Y., & Deshpande, K. H. (2010). Role of oxidative stress in various stages of psoriasis. Indian journal of clinical biochemistry, 25, 388-392.
Koh, D., Yang, Y., Khoo, L., Nyunt, S. Z., Ng, V., & Goh, C. L. (2004). Salivary immunoglobulin A and lysozyme in patients with psoriasis. Annals-Academy of Medicine Singapore, 33, 307-310.
Krasteva, A., Grozdev, I., Ivanova, A., Altankova, I., Bocheva, S., Kisselova, A., & Tsankov, N. (2009). Psoriatic patients and salivary components. Oral Health and Dental Management in the Black Sea Countries, 8(2), 12-15.
Liu, R., Yang, Y., Yan, X., & Zhang, K. (2013). Abnormalities in cytokine secretion
from mesenchymal stem cells in psoriatic skin lesions. European Journal of Dermatology, 23(5), 600-607.
Mastrolonardo, M., Alicino, D., Zefferino, R., Pasquini, P., & Picardi, A. (2007). Effect of psychological stress on salivary interleukin 1β in psoriasis. Archives of medical research, 38(2), 206-211.
Modin, A., Weitzberg, E., Hökfelt, T., & Lundberg, J. M. (1994). Nitric oxide synthase in the pig autonomic nervous system in relation to the influence of NG-nitro-L
arginine on sympathetic and parasympathetic vascular control in vivo. Neuroscience, 62(1), 189-203.
Rocha Pereira, P., Santos Silva, A., Rebelo, I., Figueiredo, A., Quintanilha, A., & Teixeira, F. (2004). The inflammatory response in mild and in severe psoriasis. British Journal of Dermatology, 150(5), 917-928.
Skutnik-Radziszewska, A., Maciejczyk, M., Fejfer, K., Krahel, J., Flisiak, I., Kołodziej, U., & Zalewska, A. (2020). Salivary antioxidants and oxidative stress in psoriatic patients: can salivary total oxidant status and oxidative status index be a plaque psoriasis biomarker?. Oxidative Medicine and
Cellular Longevity, 2020.
Soudan, R. A., Daoud, S. A., & Mashlah, A. M. (2011). Study of some salivary changes in cutaneous psoriatic patients. Saudi medical journal, 32(4), 386-389.
Stichtenoth, D. O., & Frölich, J. C. (1998). Nitric oxide and inflammatory joint diseases. British journal of rheumatology, 37(3), 246-257.
**********
Syrjänen, S. M. (1983). Chemical analysis of parotid saliva and lacrimal fluid in psoriatics. Archives of Dermatological Research, 275, 152-155.
Valenzuela, F., Fernández, J., Jiménez, C., Cavagnola, D., Mancilla, J. F., Astorga, J... & Fernández, A. (2021). Identification of IL-18 and soluble cell adhesion molecules in the gingival crevicular fluid as novel biomarkers of psoriasis. Life, 11(10), 1000.
Villanova, F., Di Meglio, P., & Nestle, F. O. (2013). Biomarkers in psoriasis and psoriatic arthritis. Annals of the rheumatic diseases, 72(suppl 2), ii104-ii110.
Wagener, F. A., Carels, C. E., & Lundvig, D. M. (2013). Targeting the redox balance in inflammatory skin conditions. International journal of molecular sciences, 14(5), 9126-
Yamanaka, K., Yamamoto, O., & Honda, T. (2021). Pathophysiology of psoriasis: A review. The Journal of dermatology, 48(6), 722-731.
Zaher, H., Shaker, O. G., EL.Komy, M. H. M., El. Tawdi, A., Fawzi, M., & Kadry, D. (2009). Serum and tissue expression of transforming growth factor beta 1 in psoriasis. Journal of the European Academy of Dermatology and Venereology, 23(4), 406- 409.
Zalewska, A., Knaś, M., Waszkiewicz, N., Waszkiel, D., Sierakowski, S., & Zwierz, K. (2013). Rheumatoid arthritis patients with xerostomia have reduced production of key salivary constituents. Oral surgery, oral medicine, oral pathology and oral radiology, 115(4), 483-490.
