Saliva: An Emerging Adjunct Biomarker for Psoriasis –Trends, Scope and Relevance

Authors

  • Simranjit Singh Department of Oral Pathology, Dr. Harvansh Singh Judge Institute of Dental Sciences & Hospital, Panjab University, Chandigarh, 160014, India.
  • Pratibha Ramani Dept of Oral Pathology, Saveetha Dental College and Hospital. SIMATS, Chennai, Tamil Nadu 600077, India.
  • N D Jayakumar Dept. of Periodontics, Saveetha Dental College and Hospital. SIMATS, Chennai, Tamil Nadu 600077, India.
  • Sileena Jaideep Pannu Dr. Harvansh Singh Judge Institute of Dental Sciences & Hospital, Panjab University, Chandigarh, 160014, India.
  • Ravi Kant Sharma Department of Biochemistry, Dr.Harvansh Singh Judge Institute of Dental Sciences & Hospital, Panjab university, Chandigarh, 160014, India.
  • Sushil Kumar Upadhyay Department of Bio-Sciences and Technology, Maharishi Markandeshwar (Deemed to be University), Mullana-Ambala-133207, Haryana, India.
  • Anil Kumar Sharma Professor, Department of Biotechnology, Amity University, Sector 82 A, IT City Rd, Block D, Sahibzada Ajit Singh Nagar, Mohali, Panjab 140306, India.

DOI:

https://doi.org/10.48165/bpas.2023.42A.2.12

Keywords:

Psoriasis, Saliva, Biomarker

Abstract

Psoriasis is a widely prevalent chronic immuno inflammatory dermatological disease resulting from a  complex and dynamic interplay of genetic,  environmental, and immunological aetiologies. It  manifests as characteristic erythematous psoriatic  plaques visible to the naked eye, but prognostic  biomarkers for disease monitoring and therapeutic  effectiveness are still absent. Saliva is a biological fluid  that, besides being critical to maintaining oral  homeostasis, harbors various salivary microbiota and  inflammatory markers. It can be easily collected, stored,  and analyzed. Oral fluids offer an excellent advantage  for biomarker study as they are non-invasive and fast  techniques. Studies showed that the saliva of healthy  individuals and those with psoriasis had differences in  the levels of inflammatory cytokines, immunoglobulin  A, and anti-oxidant biomarkers. In GCF, individuals  with psoriasis showed higher levels of S100A8, IL-18,  and sE-selectin than healthy individuals, independent of  periodontal status. Oxidative stress(OS) is one of the  pathogenetic factors of psoriasis. Thus levels of ROS and  anti-oxidants can also become important factors in  diagnosis. 

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Published

2023-12-20

Issue

Vol. 42 No. 2 (2023): Bulletin of Pure and Applied Sciences-Zoology (Jul-Dec) 2023

Section

Articles

How to Cite

Saliva: An Emerging Adjunct Biomarker for Psoriasis –Trends, Scope and Relevance. (2023). Bulletin of Pure & Applied Sciences- Zoology , 42(2), 340–346. https://doi.org/10.48165/bpas.2023.42A.2.12