Effect of Hibiscus rosa-sinensis and Camel Milk on the Reproduction of Diabetic Male Albino Rats – A Review
DOI:
https://doi.org/10.48165/bpas.2023.42A.2.10Keywords:
Diabetes mellitus, Blood glucose, Reproduction, Hibiscus rosa-sinensis, Camel milkAbstract
Diabetes mellitus is a long-term medical condition identified by high blood sugar levels. Two forms of diabetes most commonly occur. Type I diabetes occurs in children and type II diabetes is normally found in adults. Although diabetes affects the whole body's function surprisingly, it gives rise to male infertility. Diabetes causes impotency, and ejaculatory disorders and decreases libido in males. Hibiscus rosa-sinensis and camel milk both are known for their anti-diabetic properties. Both are able to deal with the oxidative stress caused by diabetes because of their antioxidant properties. Both have other properties like antibacterial, anti-inflammatory, antifungal, antimicrobial, antitumor, cardio-protective, hepato-protective etc. The crude extract of Hibiscus rosa-sinensis has insulin-secreting activity, significantly lowering the glucose level of blood in diabetic rats. Camel milk contains insulin-like protein which is also reported to positively decrease the blood sugar level.
Downloads
References
Adhirajan, N., Kumar, T. R., Shanmugasundaram, N., & Babu, M. (2003). In vivo and in vitro evaluation of hair growth potential of Hibiscus rosa-sinensis Linn. Journal of Ethnopharmacology, 88(2-3), 235-239.
Afiune, L. A. F., Leal-Silva, T., Sinzato, Y. K., Moraes-Souza, R. Q., Soares, T. S., Campos, K. E., ... & Volpato, G. T. (2017). Beneficial effects of Hibiscus rosa-sinensis L. flower aqueous extract in pregnant rats with diabetes. PLoS One, 12(6), e0179785.
Agarwal, R. P., Swami, S. C., Beniwal, R., Kochar, D. K., Sahani, M. S., Tuteja, F. C., & Ghouri, S. K. (2003). Effect of camel milk on glycemic control, risk factors and diabetes quality of life in type-1 diabetes: A randomized prospective controlled study. Journal of Camel Practice and Research, 10(1), 45-50.
Agrawal, R. P., Beniwal, R., Sharma, S., Kochar, D. K., Tuteja, F. C., Ghorui, S. K., & Sahani, M. S. (2005). Effect of raw camel milk in type 1 diabetic patients: 1 year randomised study. Journal of Camel Practice and Research, 12(1), 27.
Agrawal, R. P., Saran, S., Sharma, P., Gupta, R. P., Kochar, D. K., & Sahani, M. S. (2007). Effect of camel milk on residual beta-cell function in recent-onset type 1 diabetes. Diabetes research and clinical practice, 77(3), 494-495.
Al Kanhal, H. A. (2010). Compositional, technological and nutritional aspects of dromedary camel milk. International Dairy Journal, 20(12), 811-821.
Akbar, N. (2011). Science of camel and yak milk: human nutrition and health perspectives. Food and Nutrition Sciences, 2011.
Alam, M. M., Siddiqui, M. B., & Husain, W. (1990). Treatment of diabetes through herbal drugs in rural India. Fitoterapia, 61(3), 240- 242.
Althnaian, T., Albokhadaim, I., & El-Bahr, S. M. (2013). Biochemical and histopathological study in rats intoxicated with carbon tetrachloride and treated with camel milk. SpringerPlus, 2(1), 57.
American Diabetes Association, 2004. Diagnosis and classification of diabetes. Diabetes Care 27 (1), S5–S10.
Amin, A., Hamza, A. A., Kambal, A., & Daoud, S. (2008). Herbal extracts counteract cisplatin‐mediated cell death in rat testis. Asian Journal of Andrology, 10(2), 291-
Ansari, P., Azam, S., Hannan, J. M. A., Flatt, P. R., & Wahab, Y. H. A. (2020). The anti hyperglycaemic activity of H. rosa-sinensis leaves is partly mediated by inhibition of carbohydrate digestion and absorption, and enhancement of insulin secretion. Journal of Ethnopharmacology, 253, 112647.
Atkinson, M. A., & Maclaren, N. K. (1994). The pathogenesis of insulin-dependent diabetes mellitus. New England journal of medicine, 331(21), 1428-1436.
Ballester, J., Muñoz, M. C., Domínguez, J., Rigau, T., Guinovart, J. J., & Rodríguez‐Gil, J. E. (2004). Insulin‐dependent diabetes affects testicular function through FSH‐and
LH‐linked mechanisms. Journal of andrology, 25(5), 706-719.
Bhaskar, A., Nithya, V., & Vidhya, V. G. (2011). Phytochemical screening and in vitro antioxidant activities of the ethanolic extract of Hibiscus rosa sinensis L. Annals of Biological Research, 2(5), 653-661.
Budin, S. B., Rahman, W. Z. A., Jubaidi, F. F., Yusof, N. L. M., Taib, I. S., & Zainalabidin, S. (2018). Roselle (Hibiscus sabdiriffa) polyphenol-rich extract prevents testicular damage in diabetic rats. Journal of Applied Pharmaceutical Science, 8(2), 65-70.
Davis, SN. (2006). Insulin, Oral hypoglycemic agents and the pharmacology of the endocrine pancreas. In Goodman and Gilmans the Pharmacological Basis of Therapeutics. Brunton LL (ed.). McGraw-Hill, New York; 1613-1645.
Dinulovic, D., & Radonjic, G. (1990). Diabetes mellitus/male infertility. Archives of andrology, 25(3), 277-293.
Ebaid, H., Abdel-Salam, B., Hassan, I., Al Tamimi, J., Metwalli, A., & Alhazza, I. (2015). Camel milk peptide improves wound healing in diabetic rats by orchestrating the redox status and immune response. Lipids in health and disease, 14(1), 1-10.
El-Azab, N. E. E., & Elmahalaway, A. M. (2020). A Histological and Immunohistochemical Study on Testicular Changes Induced by Sliver Nanoparticles in Adult Rats and the Possible Protective Role of Camel Milk. Egyptian Journal of Histology, 42(4), 1044-1058.
EL SAID, E. S. E. S., EL SAYED, G. R., & Tantawy, E. (2010, January). Effect of camel milk on oxidative stresses in experimentally induced diabetic rabbits. Veterinary research forum.
Escrig, A., Marin, R., Abreu, P., Luis Gonzalez-Mora, J., & Mas, M. (2002). Changes in mating behaviour, erectile function, and nitric oxide levels in penile corpora cavernosa in streptozotocin-diabetic rats. Biology of reproduction, 66(1), 185-189.
Gad, S. B., Fayed, A. H. H., Hafez, M. H., & Abdel-Hafeiz, A. H. (2018). Does camel milk have a positive impact on rat reproductive functions? Alexandria Journal for Veterinary Sciences, 59(1).
Gauthaman, K. K., Saleem, M. T., Thanislas, P. T., Prabhu, V. V., Krishnamoorthy, K. K., Devaraj, N. S., & Somasundaram, J. S. (2006). Cardioprotective effect of the Hibiscus rosa sinensis flowers in an oxidative stress model of myocardial ischemic reperfusion injury in the rat. BMC Complementary and Alternative Medicine, 6(1), 1-8.
Ghanbari, E., Nejati, V., Najafi, G., Khazaei, M., & Babaei, M. (2015). Study on the effect of royal jelly on reproductive parameters in streptozotocin-induced diabetic rats. International journal of fertility & sterility, 9(1), 113.
Giorgi, C., Agnoletto, C., Baldini, C., Bononi, A., Bonora, M., Marchi, S., & Pinton, P. (2010). Redox control of protein kinase C: cell-and disease-specific aspects. Antioxidants & redox signalling, 13(7), 1051-1085.
Ho, T. M., Zou, Z., & Bansal, N. (2021). Camel milk: A review of its nutritional value, heat stability, and potential food products. Food Research International, 110870.
Idris, M. H. M., Budin, S. B., Osman, M., & Mohamed, J. (2012). Protective role of Hibiscus sabdariffa calyx extract against streptozotocin-induced sperm damage in diabetic rats. Excli Journal, 11, 659.
Imani, M., Talebi, A. R., Fesahat, F., Rahiminia, T., Seifati, S. M., & Dehghanpour, F. (2021). Sperm parameters, DNA integrity, and protamine expression in patients with type II diabetes mellitus. Journal of Obstetrics and Gynaecology, 41(3), 439-446.
Jadhav, V. M., Thorat, R. M., Kadam, V. J., & Sathe, N. S. (2009). Traditional medicinal uses of Hibiscus rosa-sinensis. J Pharm Res, 2(8), 1220-1222.
Kadve, S., Malakar, R., Yadav, M., & Tiwari, A. (2012). Genetic variation on Hibiscus species by using Rapd Markers. Advance Research in Pharmaceuticals and Biologicals, 2(1), 9-21.
Khatib, N. A., Ghoshal, G., Nayana, H., Joshi, R. K., Taranalli, A. D., NA MK, N. N., ... & RK MJ, T. A. (2009). Effect of Hibiscus rosa-sinensis extract on modifying cyclophosphamide-induced genotoxicity
and scavenging free radicals in Swiss albino mice. Pharmacologyonline, 3, 796-808.
Kothari, S., Thompson, A., Agarwal, A., & du Plessis, S. S. (2010). Free radicals: their beneficial and detrimental effects on sperm function.
Kumar, V., Mahdi, F., Khanna, A. K., Singh, R., Chander, R., Saxena, J. K., & Singh, R. K. (2013). Antidyslipidemic and antioxidant activities of Hibiscus rosa sinensis root extract in alloxan-induced diabetic rats. Indian Journal of Clinical Biochemistry, 28(1), 46-50.
Limon, A., Gallegos-Perez, J. L., Reyes-Ruiz, J. M., Aljohi, M. A., Alshanqeeti, A. S., & Miledi, R. (2014). The endogenous GABA bioactivity of camel, bovine, goat and human milks. Food Chemistry, 145, 481-487.
Malik, A., Al-Senaidy, A., Skrzypczak Jankun, E., & Jankun, J. (2012). A study of the anti-diabetic agents of camel milk. International journal of molecular medicine, 30(3), 585-592.
Mamun, A., Islam, S., Alam, A. K., Rahman, M. A. A., & Rashid, M. (2013). Effects of ethanolic extract of Hibiscus rosa-sinensis leaves on alloxan-induced diabetes with dyslipidemia in rats. Bangladesh Pharmaceutical Journal, 16(1), 27-31.
Maresch, C. C., Stute, D. C., Alves, M. G., Oliveira, P. F., de Kretser, D. M., & Linn, T. (2018). Diabetes-induced hyperglycemia impairs male reproductive function: a systematic review. Human Reproduction Update, 24(1), 86-105.
Matkovics, B., Varga, S. I., Szabo, L., & Witas, H. (1982). The effect of diabetes on the activities of the peroxide metabolism enzymes. Hormone and Metabolic Research, 14(02), 77-79.
Mohamad, R. H., Zekry, Z. K., Al-Mehdar, H. A., Salama, O., El-Shaieb, S. E., El-Basmy, A. A., ... & Sharawy, S. M. (2009). Camel milk as an adjuvant therapy for the treatment of type 1 diabetes: verification of a traditional ethnomedical practice. Journal of medicinal food, 12(2), 461-465.
Mohamed, A. A. R., Abdellatief, S. A., Khater, S. I., Ali, H., & Al-Gabri, N. A. (2019). Fenpropathrin induces testicular damage, apoptosis, and genomic DNA
damage in adult rats: Protective role of camel milk. Ecotoxicology and environmental safety, 181, 548-558.
Moqbel, F. S., Naik, P. R., Najma, H. M., & Selvaraj, S. (2011). Antidiabetic properties of Hibiscus rosa sinensis L. leaf extract fractions on non-obese diabetic (NOD) mouse.
Murillo Pulgarín, J. A., Garcia Bermejo, L. F., & Carrasquero Durán, A. (2017). Determination of the antioxidant activity of hibiscus flowers by flow injection analysis with chemiluminescence detection. Analytical Letters, 50(1), 186-196.
Navarro‐Casado, L., Juncos‐Tobarra, M. A., Chafer‐Rudilla, M., De Onzono, L. Í., Blazquez‐Cabrera, J. A., & Miralles‐Garcia, J. M. (2010). Effect of experimental diabetes and STZ on male fertility capacity. Study in rats. Journal of Andrology, 31(6), 584-592.
Nna, V. U., Bakar, A. B. A., & Mohamed, M. (2017). Diabetes mellitus-induced male reproductive impairment: the role of natural products: a review. J Appl Pharm Sci, 7, 233-
Ojiako, O. A., Chikezie, P. C., & Ogbuji, A. C. (2016). Blood glucose level and lipid profile of alloxan-induced hyperglycemic rats treated with single and combinatorial herbal formulations. Journal of traditional and complementary medicine, 6(2), 184-192.
Omolaoye, T. S., Skosana, B. T., & du Plessis, S. S. (2018). Diabetes mellitus-induction: Effect of different streptozotocin doses on male reproductive parameters. Acta histochemica, 120(2), 103-109.
Patel, S., & Adhav, M. (2016). Comparative phytochemical screening of ethanolic extracts (flower and leaf) of morphotypes of Hibiscus Rosa-sinensis Linn. Journal of Pharmacognosy and Phytochemistry, 5(3), 93.
Pethe, M., Yelwatkar, S., Gujar, V., Varma, S., & Manchalwar, S. (2017). Antidiabetic, hypolipidemic and antioxidant activities of Hibiscus rosa sinensis flower extract in alloxan-induced diabetes in rabbits. Int J Biomed Adv Res, 8, 138-43.
Pitocco, D., Zaccardi, F., Di Stasio, E., Romitelli, F., Santini, S. A., Zuppi, C., & Ghirlanda, G. (2010). Oxidative stress, nitric oxide, and diabetes. The review of diabetic studies: RDS, 7(1), 15.
Kumar, T. R., Kumar, E. U., Sekar, M., & Kumar, M. S. (2011). Antidiabetic activity of methanolic extract of Hibiscus cannabinus in streptozotocin-induced diabetic rats. International Journal of Pharma and Bio Sciences, 2(1), P125-P130.
Rao, B. K., Sudarshan, P. R., Rajasekhar, M. D., Nagaraju, N., & Rao, C. A. (2003). Antidiabetic activity of Terminalia pallida fruit in alloxan-induced diabetic rats. Journal of Ethnopharmacology, 85(1), 169-172.
Rashid, K., & Sil, P. C. (2015). Curcumin ameliorates testicular damage in diabetic rats by suppressing cellular stress-mediated mitochondria and endoplasmic reticulum
dependent apoptotic death. Biochimica et biophysica acta (BBA)-molecular basis of disease, 1852(1), 70-82.
Reddy, C. M., Murthy, D. R., & Patil, S. B. (1997). Antispermatogenic and androgenic activities of various extracts of Hibiscus rosasinesis in albino mice. Indian Journal of Experimental Biology, 35(11), 1170-1174.
Sachdewa, A., Nigam, R., & Khemani, L. D. (2001). Hypoglycemic effect of Hibiscus rosa sinensis L. leaf extract in glucose and streptozotocin-induced hyperglycemic rats.
Sachdewa, A., & Khemani, L. D. (2003). Effect of Hibiscus rosa sinensis Linn. Ethanol flower extract on blood glucose and lipid profile in streptozotocin-induced
diabetes in rats. Journal of Ethnopharmacology, 89(1), 61-66.
Sakuraba, H., Mizukami, H., Yagihashi, N., Wada, R., Hanyu, C., & Yagihashi, S. (2002). Reduced beta-cell mass and expression of oxidative stress-related DNA damage in the islet of Japanese Type II diabetic patients. Diabetologia, 45(1), 85-96.
Sankaran, M., & Vadivel, A. (2011). Antioxidant and Antidiabetic effect of Hibiscus rosa-sinensis flower extract on Streptozotocin induced experimental rats-a dose response study. Notulae Scientia Biologicae, 3(4), 13-21.
Saumya, S. M., & Basha, P. M. (2017). Fluoride exposure aggravates the testicular damage and sperm quality in diabetic mice: protective role of ginseng and banaba. Biological trace element research, 177(2), 331-344.
Scarano, W. R., Messias, A. G., Oliva, S. U., Klinefelter, G. R., & Kempinas, W. G. (2006). Sexual behaviour, sperm quantity and quality after short‐term streptozotocin‐induced hyperglycaemia in rats. International journal of andrology, 29(4), 482-488.
Shabo, Y., Barzel, R., Margoulis, M., & Yagil, R. (2005). Camel milk for food allergies in children. IMAJ-RAMAT GAN-, 7(12), 796.
Shahriari, S., Hejazi, N., & Eftekhari, M. H. (2018). The role of camel milk in treatment of type 2 diabetes: a review. International Journal of Nutrition Sciences, 3(3), 120-126.
Sharma, S., Khan, N., & Sultana, S. (2004). Effect of Onosma echioides on DMBA/croton oil mediated carcinogenic response, hyperproliferation and oxidative damage in murine skin. Life Sciences, 75(20), 2391-2410.
Sharma, K., Pareek, A., & Chauhan, E. S. (2016). Evaluation of the hyperglycemic and hyperlipidemic mitigating impact of Hibiscus rosa-sinensis (Gudhal) flower in type II diabetes mellitus subjects. International Journal of Applied Biology and Pharmaceutical Technology, 7(2), 223-228.
Sboui, A., Khorchani, T., Djegham, M., Agrebi, A., Elhatmi, H., & Belhadj, O. (2010). Anti‐diabetic effect of camel milk in alloxan‐induced diabetic dogs: a dose–
response experiment. Journal of animal physiology and animal nutrition, 94(4), 540- 546.
Shivananda Nayak, B., Sivachandra Raju, S., Orette, F. A., & Chalapathi Rao, A. V. (2007). Effects of Hibiscus rosa sinensis L (Malvaceae) on wound healing activity: a preclinical study in a Sprague Dawley rat. The international journal of lower extremity wounds, 6(2), 76-81.
Shrilatha, B. (2007). Early oxidative stress in testis and epididymal sperm in streptozotocin-induced diabetic mice: its progression and genotoxic consequences. Reproductive Toxicology, 23(4), 578-587.
Singh, R., Ghorui, S. K., & Sahani, M. S. (2006). Camel milk: Properties and
processing potential. Sahani, MS The Indian camel. NRCC, Bikaner, 59-73.
Sivaraman, C. M., & Saju, F. (2021). Medicinal value of Hibiscus rosa sinensis: A review. International Journal of Pharmacognosy and Chemistry, 1-11.
Tiwari, B. K., Pandey, K. B., Abidi, A. B., & Rizvi, S. I. (2013). Markers of oxidative stress during diabetes mellitus. Journal of biomarkers, 2013.
Usmanghani, K., Saeed, A., & Alam, M. T. (1997). Indusyunic medicine. Department of Pharmacognosy, Faculty of Pharmacy, University of Karachi, Pakistan, 363-364.
Vastrad, J. V., & Byadgi, S. A. (2018). Phytochemical screening and antibacterial activity of Hibiscus rosa-sinensis leaf extracts. International Journal of Current Microbiology and Applied Sciences, 7(3), 3329-
Venkatesh, S., & Thilagavathi, J. (2008). Anti-diabetic activity of flowers of Hibiscus rosasinensis. Fitoterapia, 79(2), 79-81.
Vikram, A., Tripathi, D. N., Ramarao, P., & Jena, G. B. (2008). The intervention of D glucose ameliorates the toxicity of streptozotocin in accessory sex organs of the rat. Toxicology and applied pharmacology, 226(1), 84-93.
Vimala, H., Naik, P. R., & Chandavar, V. R. (2008). The insulin-secreting activity of Hibiscus rosa sinensis Linn, leaf extract in diabetes-induced Wistar rat. The Bioscan, 3, 293.
Wei, W., Liu, Q., Tan, Y., Liu, L., Li, X., & Cai, L. (2009). Oxidative stress, diabetes, and diabetic complications. Haemoglobin, 33(5), 370-377.
Whiting, D. R., Guariguata, L., Weil, C., & Shaw, J. (2011). IDF diabetes atlas: global estimates of the prevalence of diabetes for 2011 and 2030. Diabetes research and clinical practice, 94(3), 311-321.
Wild, S., Roglic, G., Green, A., Sicree, R., & King, H. (2004). Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes care, 27(5), 1047-1053.
Williams, G., & Pickup, J. C. (2004). Handbook of diabetes. Blackwell Pub.
Wong, N. D. (2005). Intensified screening and treatment of the metabolic syndrome for cardiovascular risk reduction. Preventive Cardiology, 8(1), 47-54.
Yadav, A. K., Kumar, R., Priyadarshini, L., & Singh, J. (2015). Composition and medicinal properties of camel milk: A Review. Asian Journal of Dairy and Food Research, 34(2), 83-
Yang, Y., & Chan, L. (2016). Monogenic diabetes: what it teaches us on the common forms of type 1 and type 2 diabetes. Endocrine Reviews, 37(3), 190-222.
Zakaria, A. D., Bayad, A. E. S., Abdel Raheem, S. M., Al-Busadah, K. A., & Albokhadaim, I. (2016). Camel's milk
*********
improves the semen characteristic in immobilization-stressed rats. Asian Journal of Animal Sciences, 10(2), 139-146.
Zaki, L. H., Mohamed, S. M., Bashandy, S. A., Morsy, F. A., Tawfik, K. M., & Shahat, A. A. (2017). Hypoglycemic and antioxidant effects of Hibiscus rosa-sinensis L. leaves extract on liver and kidney damage in streptozotocin-induced diabetic rats. African Journal of Pharmacy and Pharmacology, 11(13), 161-169.
Zhang, P., Li, T., Wu, X., Nice, E. C., Huang, C., & Zhang, Y. (2020). Oxidative stress and diabetes: antioxidative strategies. Frontiers of medicine, 14(5), 583-600.
