1-Deoxynojirimycin Mitigates Glycogen and Carbohydrate Metabolic Enzyme Alterations in High Glucose-Induced Diabetic Tilapia: Implications for Therapeutic Intervention

Authors

  • Raja Latha PG & Research Department of Zoology, NKR Government Arts College for Women, Namakkal, Tamilnadu - 637001, India.
  • Gani Sharmila Banu Associate Professor & Head, PG & Research Department of Zoology, NKR Government Arts College for Women, Namakkal, Tamilnadu - 637001, India.

DOI:

https://doi.org/10.48165/bpas.2023.42A.2.9

Keywords:

1-Deoxynojirimycin, Glycogen, Carbohydrate Metabolic Enzymes, Diabetes, Glycemic Control

Abstract

This study investigated the effects of 1- deoxynojirimycin (DNJ) on blood glucose levels, body  weight changes, glycogen levels, and carbohydrate  marker enzyme activity in a high glucose-induced  experimental diabetic tilapia model. We utilized  spectrophotometry assay methods to achieve this  objective. DNJ treatment significantly reduced blood  glucose and mitigated body weight loss compared to  the diabetic control group. Furthermore, DNJ treatment  increased glycogen levels in liver and muscle tissues,  suggesting its potential to enhance glycogen synthesis  or reduce glycogen breakdown. DNJ treatment also  modulated the activity of carbohydrate marker  enzymes, indicating its possible inhibitory effect on  enzymes involved in carbohydrate absorption and  breakdown, which in turn may improve glucose  homeostasis and control. The results of this study  highlight DNJ's potential as a therapeutic agent for  diseases associated with glycogen metabolism and  glucose homeostasis, as well as its ability to influence  body weight changes in diabetic conditions. Our  findings contribute to the growing body of research on  DNJ as a potential therapeutic agent for illnesses linked  to glycogen and underscore its therapeutic potential for  future treatments targeting glucose metabolism,  glycemic control, and weight management. 

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Published

2023-12-20

Issue

Vol. 42 No. 2 (2023): Bulletin of Pure and Applied Sciences-Zoology (Jul-Dec) 2023

Section

Articles

How to Cite

1-Deoxynojirimycin Mitigates Glycogen and Carbohydrate Metabolic Enzyme Alterations in High Glucose-Induced Diabetic Tilapia: Implications for Therapeutic Intervention. (2023). Bulletin of Pure & Applied Sciences- Zoology , 42(2), 291–304. https://doi.org/10.48165/bpas.2023.42A.2.9