Synthesis, Characterization and Screening of Substituted 4-Biphenyl acétamides against Curvalaria lunata

Authors

  • Anju Khullar Chemistry Department, GSSDGS Khalsa College, Patiala, Punjab 147001, India.

DOI:

https://doi.org/10.48165/

Keywords:

Synthesis, 4-Biphenyl Acetic Acid (4- BPAA), Substituted-4-Biphenyl acetamide, Spectral studies, antimicrobial activity, Anti Fungal Properties

Abstract

A new series of Substituted-4-Biphenyl acetamides have been synthesized by  condensation of 4-Biphenyl acetic acid with  different primary amines (aromatic and  aliphatic). 4-Biphenyl Acetic Acid was first  treated with Thionyl Chloride in dry benzene to  prepare substituted-4-biphenyl acetyl chloride,  which is then treated with different aliphatic or  aromatic amines to synthesize various  substituted-4-biphenyl Acid-amide derivatives.  The Structure of newly synthesized compounds  has been established by analytical and spectral  methods. These all six biphenyl compounds were  screened for antimicrobial activity. All  compounds at different concentrations were  analyzed for antifungal activity via disc diffusion  method. The antimicrobial activity was screened  against fungus Curvalaria lunata. All six  compounds showed moderate to good activity  against selected fungal strain. These synthesized  compounds have shown Anti-fungal properties  when they tested against Curvalaria lunata. 

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Published

2019-08-12

Issue

Vol. 38 No. 2 (2019): Bulletin of Pure and Applied Sciences Chemistry (Jul-Dec) 2019

Section

Articles

How to Cite

Synthesis, Characterization and Screening of Substituted 4-Biphenyl acétamides against Curvalaria lunata . (2019). Bulletin of Pure and Applied Sciences-Chemistry , 38(2), 106–114. https://doi.org/10.48165/