Kinetics and thermodynamics of thermal degradation and antimicrobial activity of zinc phenothiazine oleate complex

Authors

  • Neha Mathur Department of Chemistry, Pt. N.K.S. Govt. P.G. College, Dausa-303303, Rajasthan, India
  • Biplab Manna Department of Chemistry, Pt. N.K.S. Govt. P.G. College, Dausa-303303, Rajasthan, India
  • Arun Kumar Sharma Department of Chemistry, Govt. P.G. College, Jhalawar-326001, Rajasthan, India

DOI:

https://doi.org/10.48165/

Keywords:

Kinetics, thermodynamics, degradation, antimicrobial, phenothiazine

Abstract

The role of metals in organic synthesis has been  well known from the beginning of the  development of synthetic procedure in organic  Chemistry. Heterocyclic complexes have  attracted increasing interest because of their role  in the understanding of molecular process  occurring in biochemistry and coordination  chemistry. The Nitrogen donor aromatic ligand  constitutes an important and interesting class of  drugs / dyes not only for synthetic investigation  but also for their usefulness to resist diseases.  Colloidal systems are extremely wide spread in  nature and are of great practical importance in  our daily life. Surfactants are very useful in  modern engineering and pharmaceuticals due to  formation of micelles in solutions and high  surface activity. Present work has been initiated  with a view to obtain a profile as to the nature  and structure of complex of phenothiazine with  zinc oleate in different non-aqueous solvents that  are of great significance in explaining their  characteristics under different conditions. The  present work reveals synthesis of zinc soap and  its complex with phenothiazine ligand. For this  synthesis the para substituted aniline was  selected as the most suitable initial compound. An analytical and spectral study (IR, NMR) of  this complex has been done. In order to know  their thermal stability, thermogravimetric  analysis has been done. A biocidal activity of  complex has been carried to access their  comparative toxicity. 

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References

N. Mathur and A.K. Sharma, Synthesis of Hetero-cyclic compounds for Bio-medical Applications“ ISBN 978-613-8-05861-8” LAP LAMBERT Academic Publishing, Germany, 2018.

N. Mathur et al.Biological Activities of Some New Environmentally Safe 2- Amino benzothiazole Complexes of Copper (II) Derived Under Microwave,Int. Arch. App. Sci. Technol, 2014,5(1) 37-42. 3. S. Khan, R. Sharma, A.K. Sharma, Antifungal Activities of Copper Surfactants derived from Neem

(Azadirecta Indica) and Karanj (Pongamiapinnata) Oils: A Pharmaceutical Application, Glob. J. Pharmaceu. Sci., 2017, 3(4), 1-6.

N. Mathur, L.C.Heda, V.K.Mathur, and P. Saxena, Study of CLSI-M44-A Disk Diffusion method for determining the susceptibility of candida species against novel complexes derived from copper stearate with 2-amino benzothiazoles. Tenside Surf Det. 2011, 48(1) 1-5.

R. Sharma, A.K. Sharma, Natural Edible Oils: Comparative Health Aspects of Sesame, Coconut, Mustard (Rape Seed) and Groundnut (Peanut) A Biomedical Approach, Biomed J Sci. & Tech Res., 2017, 1(5), 1-4.

B.K. Rai, and A. Kumar, Synthesis, characterization and biocidal activity of some Schiff base and its metal complexes of Co (II), Cu (II) and Ni (II). Oriental J Chem., 2013, 29(3), 1187-1191. 7. N. Mathur, S. Bargotya, Evaluation of novel N/S containing heterocyclic metal complexes as biologically potent agents, Res. J. Chem. Sci. 2018, 8(4),30-34.

S. Bargotya, N. Mathur and A.K. Sharma, Antimicrobial & DNA cleavage studies of heterocyclic metal complexes“ISBN978-613-8-34627-2’’ LAP LAMBERT Academic Publishing, Germany, 2018. 9. N. Mathur, S.Bargotya, B. Manna, and A. Kasana, Antifungal screening and oxidation behaviour of some microwave assisted benzothaizene drugs, Int. J. Chem. Sci.2014, 12(2), 533-546. 10. A. K. Sharma, M. Saxena, R. Sharma, Synthesis, spectroscopic and fungicidal studies of Cu (II) soaps derived from groundnut and sesame oils and their urea complexes, Bulletin Pure Appl. Sci., 2017, 36(2), 26-37.

Fugu M.B., Ndahi N.P., Paul B.B. and Mustapha A.N. (2013). Synthesis, characterization, and antimicrobialstudies of some vanillin schiff base metal (II) complexes. JChem Pharm Res, 5, 22, 28. 11. N. Mathur, S. Bargotya, Advances in the Research of Novel N/S Containing Metal Complexes as Potent Antioxidants,J Applied Chem., 2017,10(8),18-23.

A. K. Sharma, R. Sharma, M. Saxena, Biomedical and antifungal application of Cu(II) soaps and its urea complexes derived from various oils. Open access J Trans Med res, 2018, 2(2), 40-43. 13. S. Bargotya, N. Mathur and A.K. Sharma, Physico-chemical analysis of environmentally safe complexes of copper“ISBN978-613-8-34672-2” LAP LAMBERT Academic Publishing, Germany, 2018. 14. N. Mathur, S. Bargotya, DNA–Binding and Cleavage Studies of Macrocyclic Metal Complexes Containing Heteroatomic Ligands, Chem. Sci. Trans., 2016, 5(1), 117-124.

R. Bhutra, R. Sharma, A.K. Sharma,Synthesis, Characterization and fungicidal activities of Cu (II) surfactants derived from groundnut and mustard oils treated at high temperatures, J. Inst. Chemists (India), 2018,90(3) 66-80.

V.V. Pillai, B. Sreekanth, DNA binding and antimicrobial studies of Ag (II) and Cu (II) metalcomplexes containing mixed ligands of 1, 10- phenanthroline and 8-hydroxyuinoline, Int J Pharm Bio Sci, 2013, 4, 739-747.

P. Tank, R. Sharma, A.K. Sharma, A Pharmaceutical approach & Antifungal activities of Copper Soaps with their N & S donor complexes derived from Mustard and Soyabean oils, Glob. J Pharmaceu. Sci., 2017, 3(4), 1-6.

A.K. Sharma, R. Sharma, A. Gangwal, Biomedical and fungicidal application of copper surfactants derived from pure fatty acid, Organic & Medicinal Chem.IJ2018, 5(5), 1-3. 19. N. Mathur, S.Bargotya, A facile synthesis and biological evaluation of some macro cyclic copper complexes, Int. J. Phar. Sci. Res., 2015, 6(6) 2538-2345.

N. Mathur, S.Bargotya, synthesis characterization and plant growth regulatory activity of metal complexes with some bioactive ligands, World J Phar and Pharmace Sci., 2016, 5(11)945-955. 21. P. Jain, S. Kachhwaha, S.L. Kothari, Chloroplast ultra structure, photosynthesis and enzyme activities in regenerated plants of Stevia rebaudiana (Bert.) Bertoni as influenced by copper sulphate in the medium, Ind. J. Exp.Bio., 2014, 52, 898-904.

R. Bhutra, R. Sharma, A.K. Sharma, Fungicidal Activities of Cu (II) Soaps Derived From Various Oils Treated at High Temperature for Biomedical Use, SAJ Biotechnol, 2018, 5:103, 1-3. 23. A. Joram, R. Sharma, A.K. Sharma, Thermal degradation of complexes derived from Cu (II) groundnut soap (Arachishypogaea) and Cu (II) sesame soap (Sesamumindicum), Z phys.Chem. 2018, 232(4) 459-470.

P. Kapoor, N.Fahmi, R.V. Singh, Microwave assisted synthesis, spectroscopic, electrochemical and DNAcleavage studies of lanthanide (III) complexes with coumarin based imines SpectrochimicaActa Part A: Molecular and Biomolecular Spectroscopy, 2011, 83(1), 74-81.

N. Mathur, M.P. Dobhal, N. Jain, A Comparative Antibacterial Analysis of Substituted Benzothiazole and Substituted Phenylthiourea Complexes with Copper Metal, Int. J Green and herb Chem., 2017, 7(1), 1- 6.

N. Mathur, S. bargotya, R. Mathur, Thermogravimetric Analysis of Microwave Assisted Novel Macromolecular Complexes of Metal Surfactants, J App. Chem.2014, 3(2), 712-719. 27. P. Tank, R. Sharma, A.K. Sharma, Micellar Features and Various Interactions of Copper Soap Complexes Derived from Edible Mustard Oil in Benzene at 303.15 K Curr. Phy. Chem. 2018, 8(1), 46-57.

S. Sharma, R. Sharma, A.K. Sharma, Synthesis, Characterization, and thermal degradation of Cu (II) Surfactants for sustainable green chem. Asian J. Green Chem., 2017, 2(2), 129-140. 29. A. K. Sharma, S. Sharma, R. Sharma, Thermal degradation of Cu (II) metallic Soaps and their Characterizations. A Pharmaceutical Application, Chronicles of Pharmaceutical Science, 2017, 1(5), 312-319.

N. Mathur, B. Manna, TGA Analysis of Transition Metal Complexes Derived from Phenothiazine Ligands, Int J Sci. Eng. Res. 2018, 6(3), 47-57.

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Published

2020-03-03

Issue

Vol. 38 No. 1 (2019): Bulletin of Pure and Applied Sciences Chemistry (Jan-Jun) 2019

Section

Articles

How to Cite

Kinetics and thermodynamics of thermal degradation and antimicrobial activity of zinc phenothiazine oleate complex . (2020). Bulletin of Pure and Applied Sciences-Chemistry , 38(1), 13–26. https://doi.org/10.48165/