In Search of New Analogues as Anti-Fungal Agents

Authors

  • Souvik Sur Research and Development Center, Teerthanker Mahaveer University, Moradabad, Uttar Pradesh 244001, India.

DOI:

https://doi.org/10.48165/

Keywords:

Clotrimazole, Designed-derivatives, anti-fungal drugs, PATCHDOCK, Docking score

Abstract

Development of new Clotrimazole derivatives was studied here. Automated prediction of protein-small  molecule interactions is one of the most challenging problems in structural biology as well as in  medicinal chemistry. Many biological studies, both in academia and in industry, may benefit from  credible high-accuracy interaction predictions. The molecular interactions with target protein have been  discussed. A target based designing of new derivatives for future drug development presented, which  can be further informative and marketed if their biological significance stand out better than the  marketed one. The report concludes with a description of the initial efforts to prepare synthesized  compounds to recognize as better antifungal agents than the regular prescribed drugs in market. The in silico drug designing leading to initial successes are described along with future directions. 

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References

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Published

2022-12-15

Issue

Vol. 41 No. 2 (2022): Bulletin of Pure and Applied Sciences-Chemistry (Jul-Dec) 2022

Section

Articles

How to Cite

In Search of New Analogues as Anti-Fungal Agents . (2022). Bulletin of Pure and Applied Sciences-Chemistry , 41(2), 82–88. https://doi.org/10.48165/