Role of MicroRNAs in Mammalian Reproduction

Shavi; Sudha Saini; Tanya Gupta; N L Selokar; M K Singh

doi:10.48165/aru.2023.3.2.4

Authors

Shavi Embryo Biotechnology Lab, Animal Biotechnology Division, ICAR- National Dairy Research Institute, Karnal-132001 (Haryana), India
Sudha Saini Embryo Biotechnology Lab, Animal Biotechnology Division, ICAR- National Dairy Research Institute, Karnal-132001 (Haryana), India
Tanya Gupta Embryo Biotechnology Lab, Animal Biotechnology Division, ICAR- National Dairy Research Institute, Karnal-132001 (Haryana), India
N L Selokar Embryo Biotechnology Lab, Animal Biotechnology Division, ICAR- National Dairy Research Institute, Karnal-132001 (Haryana), India
M K Singh Embryo Biotechnology Lab, Animal Biotechnology Division, ICAR- National Dairy Research Institute, Karnal-132001 (Haryana), India

DOI:

https://doi.org/10.48165/aru.2023.3.2.4

Keywords:

MicroRNAs, Reproduction, Oogenesis, Spermatogenesis

Abstract

MicroRNAs are small, endogenous, non-coding RNA molecules that are around 19-25 nucleotides long. Most miRNAs are produced via transcription of DNA sequences into primary miRNAs, precursor miRNAs, and then mature miRNAs. These miRNA molecules base-pair to mRNAs to control gene expression post-transcriptionally. Mammalian genome now has over 2000 annotated miRNAs which are thought to influence one-third of the genes in the genome since each miRNA can regulate hundreds of target genes. miRNAs are involved in morphogenesis, tissue maintenance, cell development, differentiation, apoptosis, and metabolism etc. This review aims to summarize the current understanding of the role of miRNAs in various stages of mammalian reproductive biology and their involvement in reproductive disorders. We have also summarized the recent advances about miRNA and provide an updated overview of the literature, including the most recent and relevant studies.

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