Probiotics Intervention for Mitigation of Uterine Infection in Dairy Animals -An Update

Vishal  Suthar; A. J.  Dhami; Purva  Gohil; Madhavi  Joshi; D. B.  Patil; C. G.  Joshi

doi:10.48165/aru.2022.2101

Authors

Vishal Suthar Directorate of Research, Kamdhenu University, Karmayogi Bhawan, Gandhinagar-382010, Gujarat, India
A. J. Dhami Department of Gynaecology & Obstetrics, College of Veterinary Science & AH, Anand-388001, Kamdhenu University, Gujarat, India
Purva Gohil Gujarat Biotechnology Research Centre, Gandhinagar-382010, Gujarat, India
Madhavi Joshi Gujarat Biotechnology Research Centre, Gandhinagar-382010, Gujarat, India
D. B. Patil Directorate of Research, Kamdhenu University, Karmayogi Bhawan, Gandhinagar-382010, Gujarat, India
C. G. Joshi Gujarat Biotechnology Research Centre, Gandhinagar-382010, Gujarat, India

DOI:

https://doi.org/10.48165/aru.2022.2101

Keywords:

dairy, probiotic bacteria, strains, cattle, animal

Abstract

Probiotic bacteria are an important subject to explore when it comes to inhibiting infectious bacteria, also commercially available for its usage in a variety of sectors including animals and humans. Postpartum uterine infections including metritis and endometritis are common in buffaloes and cow a major problem dairy industry, as it is associated with reduced fertility and decreased milk yield. To address this issue, the present review discusses the role of probiotics in the treatment of infectious uterus and its implications in the reproductive efficiency of dairy animals. Probiotic administration in the host has proven to improve health status by competing for the nutrient utilization of infectious microbes. The antibiotic activity of probiotic bacteria is also known to reduce stress on the host. Application of the probiotic strains has been proposed as an alternative to prevent uterine infection and inflammation. Hence, this review article summarizes the effects of probiotics on metritis and endometritis in bovines. And the current studies on probiotics with their effects on the uterus include their immunomodulatory effects on the animal host.

References

Ametaj BN. A new understanding of the causes of fatty liver in dairy cows. Adv Dairy Technol. 2005;17: 97-112.

Bradford LL, Chibucos MC, Ma B, Bruno V, Ravel J. Vaginal Candida spp. genomes from women with vulvovaginal candidiasis. Pathog Dis. 2017;75(6):ftx061. doi: 10.1093/femspd/ftx061.

Deng Q, Odhiambo JF, Farooq U, Lam T, Dunn SM, Ametaj BN. Intravaginal lactic Acid bacteria modulated local and systemic immune responses and lowered the incidence of uterine infections in periparturient dairy cows. PLoS One. 2015b;10(4):e0124167. doi: 10.1371/journal.pone.0124167.

Deng Q, Odhiambo JF, Farooq U, Lam T, Dunn SM, Gänzle MG, Ametaj BN. Intravaginally administered lactic acid bacteria expedited uterine involution and modulated hormonal profiles of transition dairy cows. J Dairy Sci. 2015a;98(9):6018-28. doi: 10.3168/jds.2014-8559.

Dhami AJ, Patel BR, Panchal MT, Koringa PG. Metagenomics of vaginal microbiota of buffaloes with different reproductive status. Proce. XXXV Annual Convention of ISSAR and International Symposium on "Global Perspectives to Enhance Livestock Fertility through Modern Reproductive Techniques for Doubling Farmer's Income" held at Veterinary College (TNUVAS), Namakkal, India 18-20 December, 2019, p. 55.

Drillich M, Beetz O, Pfützner A, Sabin M, Sabin HJ, Kutzer P, Nattermann H, Heuwieser W. Evaluation of a systemic antibiotic treatment of toxic puerperal metritis in dairy cows. J Dairy Sci. 2001;84(9):2010-7. doi: 10.3168/jds.S0022-0302(01)74644-9.

Gajer P, Brotman RM, Bai G, Sakamoto J, Schütte UM, Zhong X, Koenig SS, Fu L, Ma ZS, Zhou X, Abdo Z, Forney LJ, Ravel J. Temporal dynamics of the human vaginal microbiota. Sci Transl Med. 2012;4(132):132ra52. doi: 10.1126/scitranslmed.3003605.

Gärtner MA, Bondzio A, Braun N, Jung M, Einspanier R, Gabler C. Detection and characterisation of Lactobacillus spp. in the bovine uterus and their influence on bovine endometrial epithelial cells in vitro. PLoS One. 2015;10(3):e0119793. doi: 10.1371/journal.pone.0119793.

Genís S, Sánchez-Chardi A, Bach À, Fàbregas F, Arís A. A combination of lactic acid bacteria regulates Escherichia coli infection and inflammation of the bovine endometrium. J Dairy Sci. 2017;100(1):479-492. doi: 10.3168/jds.2016-11671.

Gohil, P., Patel, K., Purohit, K., Chavda, D., Puvar, A., Suthar V.S., Patil D. B, Joshi M. and Joshi C.G. (2021). Metagenomic analysis of bacterial communities during estrous cycle in Bos indicus. Trop Anim Hlth Prod (In press).

Jeon SJ, Galvão KN. An Advanced Understanding of Uterine Microbial Ecology Associated with Metritis in Dairy Cows. Genomics Inform. 2018;16(4):e21. doi: 10.5808/GI.2018.16.4.e21.

LeBlanc SJ. Review: Relationships between metabolism and neutrophil function in dairy cows in the peripartum period. Animal. 2020;14(S1):s44-s54. doi: 10.1017/S1751731119003227.

Mahesh P, Suthar V, Patil D, Joshi M, Bagatharia S, Joshi C. Vaginal microbiota during estrous cycle and its plausible association with certain hematological parameters in Bubalus bubalis. Ind J Vet Sci Biotech. 2020; 15: 54-58.

Mahesh P, Suthar VS, Patil DB, Bagatharia SB, Joshi M, Joshi CG. Dynamics of vaginal microbiota during estrous cycle and its association with reproductive hormones in Bubalus bubalis. , Ind J Vet Sci Biotech. 2021; 17: 11-18.

Moore SG, Ericsson AC, Poock SE, Melendez P, Lucy MC. Hot topic: 16S rRNA gene sequencing reveals the microbiome of the virgin and pregnant bovine uterus. J Dairy Sci. 2017;100(6):4953-4960. doi: 10.3168/jds.2017-12592.

Patel CI, Dhami AJ, Koringa PG, Lunagariya PM, Panchal MT, Joshi CG. Study on reproductive microbiota in cyclic, acyclic endometritic and pregnant crossbred cattle and its association with endocrine status. Proc. 34th ISSAR Convention and “International Symposium on “Productivity Enhancement through Augmenting Reproductive Efficiency of Livestock for Sustainable Rural Economy” held at Veterinary College, AAU, Anand, India, December 28-30, 2018: p. 52.

Rosales EB, Ametaj BN. Reproductive tract infections in dairy cows: Can probiotics curb down the incidence rate? Dairy. 2021; 2(1):40-64. doi:10.3390/dairy2010004.

Seay T, Clemmons B, Myer P and Mclean K Bacteria in the reproductive tract: They are not all bad!. Front Young Minds. 2021; 9:550269. doi: 10.3389/frym.2021.550269.

Sheldon IM, Cronin JG, Healey GD, Gabler C, Heuwieser W, Streyl D, Bromfield JJ, Miyamoto A, Fergani C, Dobson H. Innate immunity and inflammation of the bovine female reproductive tract in health and disease. Reproduction. 2014;148(3):R41-51. doi: 10.1530/REP-14-0163.

Sheldon IM, Lewis GS, LeBlanc S, Gilbert RO. Defining postpartum uterine disease in cattle. Theriogenology. 2006;65(8):1516-30. doi: 10.1016/j.theriogenology.2005.08.021.

Sheldon IM, Owens SE, Turner ML. Innate immunity and the sensing of infection, damage and danger in the female genital tract. J Reprod Immunol. 2017;119:67-73. doi: 10.1016/j.jri.2016.07.002.

Smith SB, Ravel J. The vaginal microbiota, host defence and reproductive physiology. J Physiol. 2017;595(2):451-463. doi: 10.1113/JP271694. EVergin F. Anti- und Probiotica. Hipokrates, 1954; 25: 116-119.

Wang Y, Ametaj BN, Ambrose DJ, Gänzle MG. Characterisation of the bacterial microbiota of the vagina of dairy cows and isolation of pediocin-producing Pediococcus acidilactici. BMC Microbiol. 2013;13:19. doi: 10.1186/1471-2180-13-19.