The Association between Serum Lipid Profile and Retinopathy in Type 2 Diabetes Mellitus Patients
DOI:
https://doi.org/10.48165/fy3m1160Keywords:
Dyslipidemia, Hba1c, Lipid ParametersAbstract
Background: Blood such as VLDL, intermediate density lipoprotein (IDL), chylomicrons, chylomicron remnants and lipoprotein and therefore provides a more accurate estimate of CV risk than LDL-C alone, as shown in numerous epidemiological and clinical studies. This is particularly true for patients who are already on statin therapy or those with elevated levels of VLDL-C such a patients with obesity, metabolic syndrome and diabetes. Subjects and Methods: A pre-structural proforma was used to collect baseline date detailed clinical history with clinical examination and relevant investigation was done on participating individuals. Results: Significant correlation between HbA1c and various circulating lipid parameters and significant difference of lipid parameters in two groups (</.0% and >7.0%) of glycated haemoglobin indicates that HbA1c can be used as a potential biomarker for predicting dyslipidemia in type 2 diabetic patients. Conclusion: As good control of diabetes is shown to keep the lipid levels in near normal range, it appears important to aim at critical control of DM to prevent or at least postpone the onset of various complications.
References
1. Bhardwaj S., Mistra A., Misra R. High prevalence of abdominal, intraabdominal and subcutaneous adiposity and clustering of risk factors among urban Asian Indians in North India. PLos One. 2011;6:e24362.
2. Bansal M., Shrivastava S., Mehrotra R., Agrawal V., Kasliwal R.R. Time trends in prevalence and awareness of cardiovascular risk factors in an asymptomatic North Indian urban population. J Assoc Physicians India. 2009;57:568-573.
3. KasliwalR.r., Kulshreshtha A., Agrawal S., Bansal M., Trehan N. Prevalence of cardiovascular risk factors in Indian patients undergoing coronary artery bypass surgery. J Assoc Physicians India. 2006;54:371-375.
4. Tai E.s., Emmanuel S.C., Chew S.K., Tan B.Y., Tan c.E. Isolated low HDL cholesterol: an insulin-resistant state only in the presence of fasting hypertriglyceridemia. Diabees. 1999;48:1088-1092.
5. Kulkarni K.R., Markovitz J.H., Nanda N.C., Segrest J.P. Increasd prevalence of smaller and denser 1dl particles in Asian Indians. ArteriosclerThrombVasc Biol. 1999;19:2749-2755.
6. Gupta R., guptha S., Agrawal A., Kaul V., Gaur K., Gupta V.P. Secular Trends in cholesterol lipoproteins and triglycerides and prevalence of dyslipidemias in an urban Indian population. Lipids Health Dis. 2008;740-40.
7. Mahato RV, Gyawali P, Raut PP, Regmi P, Khelanand Ps, Dipendra RP, Gyawali P. Association between glycaemic control and serum lipid profile in type 2 diabetc patients: glycatedhaemoglobin as a dual biomarker. Biomed Res. 20111;22(3);375-380.15
8. Regmi P, Gyawali P, Shrestha R, Sigdel M, Mehta KD, Majhi S. Pattern of dyslipidemia in type-2 diabetic subjects in Eastern Nepal. J Nepal Assoc Med Lab Sci. 2009;10(1):11-13.
9. Krauss RM. Lipids and lipoproteins in patients with type 2 diabetes. Diabetes Care. 2004;27(6);1496-1504.
10. Mooradian AD. Dyslipidemia in type 2 diabetes meliitus. Nat ClinPractEndocrMetab. 2009;5:150-159.
11. smith S, Lali AM. A study on lipid profile leels of diabetics and non diabetics among Naini region of Allahabad, India. Turk J biochem. 2008;33(4):138-141.
12. Hachem SB, Mooradian Ad. Familial Dyslipidaemias: an overview of generics, pathophysiology and management. Drugs. 2006;66:1949- 1969.
