To Study the Pattern and Prevalence of Lipid Profile Abnormality in Newly Diagnosed Type 2 Diabetes Mellitus
DOI:
https://doi.org/10.48165/0xmjyh47Keywords:
Dyslipidemia, hyperglycemia,, lipid profileAbstract
Background: Diabetes is one of the commonest chronic non communicable disease affecting the society at large both in developing and developed countries. Present study aimed to study the Pattern and Prevalence of lipid profile abnormality in newly diagnosed type 2 diabetes mellitus. Subjects and Methods: In this study, 100 newly diagnosed cases of type 2 diabetes mellitus patients were evaluated. A cross section of both male and female diabetes patients diagnosed within the last 3 months (new onset) was taken into study. A detailed history, clinical examination and relevant investigations were performed. Collected data were analysed by using appropriate software. Results: In our study 60% were male and 40% were female. Majority of cases were in the age group of 46-55 years, followed by in age group 56-65 years. Dyslipidemia was present in 36.66% of male and 35 % of female. Highest prevalence of dyslipidemia was present in 56 -65 age group. Hypertriglyceridemia was present in 33.33% of cases, Hypertriglyceridemia with low HDL-C was present in 33.33 % of cases, Hypertriglyceridemia with low HDL-C and low LDL –C was present in 13.88% of cases while 19.44 % were having other mixed pattern of dyslipidemia. Conclusion: Endeavour should be made to control hyperglycemia and hyperlipidia tightly by appropriate therapeutic measures so that the occurrence and worsening of complications could be mitigated.
References
1. Harrison’s principles of Internal Medicine, 20th edition 2018. P 2850.
2. Hovens MMC, Van de loar FA et al. Acetylsalicyclic acid ( aspirin) for primary prevention of cardiovascular disease in type 2 diabetes (protocol) Cochrane database os systematic reviews 2005, issue 3. Art no. CD005446.
3. International Diabetes Federation. The Diabetes Atlas, 8th ed. 2017. P 40
4. MJ Garcia, PM McNamara, T Gordon, WB Kannel. Diabetes, 1974, 23, 105-111
5. WB Kannel, DL McGee. Circulation, 1979, 59, 8-13. 6. J Stamler, D Wentworth, J Neaton, JA Schoenberger, D Feigal; for the MRFIT Research Group. Circulation, 1984, 70, 11-161.
7. SM Haffner; S Lehto; T Ronemaa; K Pyorala; M Laasko. N Engl J Med,1998,339, 229–234.
8. A Juutilainen; S Lehto; T Ronnemaa; K Pyorala; M Laakso. Diabetes Care, 2008,31, 714-719.
9. O Wirta; A Pasternak; J Mustonen; P Laippala; Y Lahde. Clin Nephrol, 1999, 51, 329-334.
10. LeRoith D, Fonseca V, Vinik A: Metabolic memory in diabetes-focus on insulin. Diabetes Metab Res Rev 2005, 21(2):85-90.
11. Garcia MJ, Mc Namara PM, Gordon T, Kannel WB. Morbidity and mortality in diabetics in the Framingham population ,Sixteen year follow-up study. 1974;23:105-11.
12. Fagan TC, Sowers J. Type 2 diabetes mellitus- greater cardiovascular risks and greater benefits of therapy. Arch Intern Med 1999; 159:1033- 34.
13. Haffiner SM, Lehto’S, Ronnemaa T, Pyorala K, Laakso M.Mortality from coronary heart disease in subjects with type 2 diabetes and in non-diabetic subjects. N Engl J Med 1998; 339:229-34.
14. Fontbonne A. Relationship between diabetic dyslipoproteinemia and coronary heart disease risk in non-insulin dependent diabetes. Diabetes Metab Rev 1991; 7:179-89.
15. Fontbonne A, Eschewege E, Cambien F, et al.Hypertriglyceridemia as a risk factor for coronary heart disease mortality in subjects with impaired glucose tolerance or diabetes: Results from 11 year follow up of the Paris Prospective study. Diabetologia 1989; 32:300-04.
16. Taskinen M. Quantitative and qualitative lipoprotein abnormalities in diabetes mellitus. Diabetes 1992; 41:12-17.
17. Hobanson JE, Austin MA. Plasma triglyceride level is a risk factor for cardiovascular disease independent of high density lipoprotein cholesterol level: a meta analysis of population based prospective studies. J Cardiovasc Risk 1996; 3:213-19.
18. West KM, Ahuja MMS, Bennet PH, Czyzyk A, DeA costaOMD, Fuller JH, Grab B, Grabauskas V, Jarrett RJ, KusakaK, Keen H, Krolewski AS, Miki E, Schilack V, Teuschev A,Watkins PJ, Stober JA. Role of circulating glucose & triglyceride concentrations and their interaction with other risk factors as determinants of arterial disease in nine diabetic population samples from the WHO Multicenter Study. Diabetes Care 1983;6:361-69.
19. Ramachandran A. Socioeconomic burden of diabetes in India.Suppl. JAPI 2007; 55:9
20. Gupta S, Kapse A. Lipid Profile Pattern in Diabetics from Central India Int J Diab Dev Ctries 2001;21:138-45
21. O P Gupta, Sanjeev phatak pandemic trends in prevalence of diabetes mellitus and associated coronary heart disease in india – their causes and prevention. int. j. diab. dev. countries (2003), vol. 23-42-43
