Clinical Profile of Patients with Chronic Kidney Disease

Authors

  • Karan VN Senior Resident, Department of General Medicine, Mahaveer Institute of Medical Sciences,Vikarabad, Telangana
  • Vishwanath VN Associate Professor, Department of General Medicine, KBNIMS, Gulbarga, Karnataka

DOI:

https://doi.org/10.48165/8j7hth40

Keywords:

Chronic kidney disease, DM, GFR

Abstract

Background: DM is the leading cause of end-stage renal disease (ESRD), non-traumatic lower extremity amputations, and adult blindness. It  also predisposes to cardiovascular diseases. With an increasing incidence worldwide, DM will be likely a leading cause of morbidity and  mortality in the future29. Chronic kidney disease (CKD) encompasses a spectrum of different pathophysiologic processes associated with  abnormal kidney function and a progressive decline in glomerular filtration rate. Subjects and Methods: A written informed consent was  obtained from all patients. History regarding the duration of hypertension, the medications being taken, coexisting medical problems, and  symptomatology suggestive of ischemic heart disease, transient ischemic attacks and that of renal involvement were documented. A detailed  history, anthropometry, vital signs, clinical examination and laboratory parameters were recorded for both the study group. Results: The Study  reveals that, there was statistically very highly significant difference of age among Type 2 diabetes mellitus with CKD and Non-diabetic  patients with CKD (P<0.001).Type 2 diabetes mellitus with CKD cases had significantly higher mean age as compare to Non-diabetic patients  with CKD cases. Conclusion: There was statistical significant difference of mean serum uric acid among vegetarians and non-vegetarians with  CKD patients (P>0.05).It’s found that vegetarians have less SUA level when compare to mixed diet patients. 

References

1. Niskanen LK, Laaksonen DE, NyyssönenK,et al. Uric acid level as a risk factor for cardiovascular and all-cause mortality in middle-aged men: a prospective cohort study. Arch Intern Med 2004;164:1546– 1551.

2. Zoppini G, Targher G, Negri C, etal.Elevated serum uric acid concentrations independently predict cardiovascular mortality in type 2 diabetic patients. Diabetes Care 2009;32:1716–1720. .

3. National Kidney Foundation. K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification,and stratification. Am J Kidney Dis 2012;39(Suppl. 1):S1–S266.

4. TangriN,Weiner DE. Uric acid, CKD, and cardiovascular disease: confounders, culprits,and circles. Am J Kidney Dis 2010;56:247–250. 5. Iseki K, Oshiro S, Tozawa M, Iseki C,Ikemiya Y, Takishita S. Significance of hyperuricemia on the early detection of renal failure in a cohort of screened subjects.Hypertens Res 2001;24:691–697. 6. Iseki K, Ikemiya Y, Inoue T, Iseki C, Kinjo K, Takishita S. Significance of yperuricemia as a risk factor for developing ESRD in a screened cohort. Am J Kidney Dis 2004;44:642–650.

7. Dharan KS, John GT, Neelakantan N, Korula A, BalakrishnanN,Kirubakaran MG, Jacob CK. Spectrum of severe chronic kidney disease in India: a clinicopathological study Natl Med J India. 2006 Sep-Oct;19(5):250-2.

8. Eknoyan G. The Renaissace kidney-nephrology in and about the sixteenth century. Semin Dial. 2012; 25(4): 451-459.

9. Emeka A Nwankwo, William W Wudiri, Amos A Gadzama. Serum Uric Acid Correlates With The Progression Of Nephropathy In Patients With Diabetes Mellitus. Pak J Med Sci October - December 2006 Vol. 22 No. 4 391-395.

10. Vahid Ansari, MehryarZargari, AtiehMakhlogh,ShivasaddatMirabedini, SaminehMotallebi. 2015.Association of Uric Acid with Antioxidant Capacity of Plasma in Patients with Type 2 Diabetic Nephropathy.ResMol Med 3(4):23- 27.

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Published

2020-01-30

How to Cite

Clinical Profile of Patients with Chronic Kidney Disease . (2020). Academia Journal of Medicine, 2(2), 175–178. https://doi.org/10.48165/8j7hth40