Renal Biopsy Findings in Lupus Nephritis and Their Correlation with Clinico-Biochemical Parameters
DOI:
https://doi.org/10.48165/mxgk7z15Keywords:
Renal biopsy, lupus nephritis, SLE, Clinical & biochemical parametersAbstract
Background: This is an observational analysis wherein we contemplated renal biopsy discoveries of 50 patients of lupus nephritis (LN) and these biopsy discoveries were associated with clinical and biochemical parameters of the LN patients. The study included 50 patients of SLE diagnosed to have renal involvement. Renal biopsy was done in every one of the 50 patients and the outcomes were ordered by the ISN/RPS arrangement of LN. Clinical and biochemical parameters were examined in all patients and they were corresponded with renal biopsy discoveries. The different biochemical parameters in our investigation were-proteinuria (100%) , raised serum creatinine (56%). Mean 24 hour protein discharge was 2386+/ - 1810 mg/day at presentation.11(22%) patients had nephrotic range proteinuria and 8 (16%) patients had proteinuria <1gm/day. Nephrotic range proteinuria was seen in LN Class IV and Class V. Hematuria was available most ordinarily in LN Class IV (in 100%) while none of the Class II LN patients had hematuria. Hypertension was most ordinarily connected with Class III and Class IV LN. Mean serum creatinine was 2.53+/ - 1.92 mg/dl. Mean serum creatinine was relatively higher on Class IV LN than in different classes of LN. In our examination most regular kind of renal biopsy finding in lupus nephritis was LN Class IV. Most serious kind of LN is Class IV LN. LN patients may have mixed lesions of Class IV and Class V LN, which was found in 2 patients (4%) in our investigation. LN Class I and LN Class VI are exceptionally uncommon at introduction of LN which were not found in renal biopsy in our examination.
References
1. Danchenko N, Satia JA, Anthony MS. Epidemiology of systemiclupus erythematosus: a comparison of worldwide diseaseburden. Lupus.
2006;15:308e318.
2. Bastian HM, Roseman JM, McGwin Jr G, et al. Systemic lupuserythematosus in three ethnic groups. XII. Risk factors forlupus nephritis after diagnosis. Lupus. 2002;11:152e160.
3. Singh S, Devidayal, Minz R, Nada R, Joshi K. Childhood lupusnephritis: 12 years experience from North India. Rhematol Int.2006;26:604e607.
4. Chakrabarti S, Ghosh AK, Bose J, De PK, Das K.Clinicopathologic study of lupus nephritis. J Indian Med Assoc.1998;96:268e271 5. D. A. Charney, G. Nassar, L. Truong, and T. Nadasdy, “‘Pauciimmune’proliferative and necrotizing glomerulonephritis withthrombotic microangiopathy in patients with systemic lupuserythematosus and lupus-like syndrome,”TheAmerican Journalof Kidney Diseases, vol. 35, no. 6, pp. 1193–1206, 2000.
6. Manzi SM, Stark VE, Ramsey-Goldman R. Systemic lupus erythematosus: Epidemiology and classification of systemic lupus erythematosus. In: Hochberg MC, Silman AJ, Smolen JS, Weinblatt M,Weisman M., editors. Rheumatology. 3rd ed. St. Louis: CV Mosby; 2003. p. 1291-6.
7. Uramoto KM, Michet CJ Jr, Thumboo J, Sunku J, O’Fallon WM, Gabriel SE. Trends in the incidence and mortality of systemic lupus erythematosus, 1950-1992. Arthritis Rheum 1999;42(1):46-50.
8. Kumar A, Malaviya AN, Singh RR, Singh YN, Adya CM, Kakkar R. Survival in patients with systemic lupus erythematosus in India. Rheumatol Int 1992;12(3):107-9.
9. Fayaz, Y. Pirson, J. P. Cosyns, J. Yango, and M. Lambert, “Pauci immune necrotizing and crescentic glomerulonephritis in a patient with systemic lupus erythematosus,” Clinical Nephrology, vol. 69, no. 4, pp. 290–293, 2008
10. J. Weening, V. D. D'Agati, M. M. Schwartz et al., “The classification of glomerulonephritis in systemic lupus ereythematosus revisited,” Kidney International, vol. 65, pp. 521–530, 2004.
11. Cameron SJ. Lupus nephritis. Disease of the month. J Am Soc Nephrol 1999;10:413-22.
12. Esdaile JM, Levinton C, Federgreen W, Hayslett JP, Kashgarian M. The clinical and renal biopsy predictors of long-term outcome in lupus nephritis: A study of 87 patients and review of the literature. Q J Med 1989;72(269):779-833.
13. Tan EM, Cohen AS, Fries JF, Masi AT, McShane DJ, Rothfield NF, et al. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1982;25(11):1271-7
14. Shobha V, Prakash R, Arvind P, Tarey SD. Histopathology of lupus nephritis: A single-center, cross-sectional study from Karnataka, India. IJRCI 2014;2(1):OA3.
