A Clinico-Hematological Study of Influenza Virus Infection

Authors

  • Shivani Shenoy K 3rd MBBS (7th Sem), Kasturba Medical College, Manipal - 576104, Manipal University, Karnataka, India
  • Raj Shekhar 3rd MBBS (7th Sem), Kasturba Medical College, Manipal - 576104, Manipal University, Karnataka, India
  • Mary Mathew Professor, Department of Pathology, Kasturba Medical College, Manipal - 576104, Manipal University, Karnataka, India
  • G Arun Kumar Professor and Head, Manipal Centre for Virus Research, Manipal - 576104, Manipal University, Karnataka, India.

DOI:

https://doi.org/10.48165/cqcff414

Keywords:

Influenza, Hematological parameters, Liver enzymes

Abstract

Background: Influenza is a seasonal infectious viral disease which accounts for approximately 3-5 million cases of severe illness and 250,000  to 500,000 deaths in a yearly outbreak. The objectives of our study were to study the various clinical presentation of influenza infection and to  correlate the demographic data and clinical symptoms with hematological parameters. Subjects and Methods: 95 cases which were positive  by One-step RT-PCR were included in the study. Elevation of serum transaminase levels, thrombocytopenia and raised creatinine levels are  important parameters which mandates vigilant follow up in patients with influenza infection. Results: The most common symptoms were fever  in 88.42% and cough in 88.42% of cases. 51.57% of patients presented with anemia on admission. 11.5% of patients had thrombocytopenia of  which 36.36% had elevated liver enzymes. 35.78% of cases had leukocytosis of which 32.35% had elevated liver enzymes. 15.78% of patients  had raised creatinine levels. Conclusion: Authors suggested that elevation of serum transaminase levels, thrombocytopenia and raised  creatinine levels are important parameters which mandates vigilant follow up in patients with influenza infection. 

References

1. Paules, C., & Subbarao, K. Influenza. The Lancet 2017; 390(10095), 697–708.

2. Cox NJ, Subbarao K. Global epidemiology of influenza: past and present. Annu Rev Med 2000; 51: 407−21.

3. Yang L, Chan KH, Suen LK, et al. Age-specific epidemic waves of influenza and respiratory syncytial virus in a subtropical city. Sci Rep 2015; 5: 10390.

4. Barker WH, Mullooly JP. Pneumonia and influenza deaths during epidemics: implications for prevention. Arch Intern Med 1982; 142: 85−89.

5. Biggerstaff M, Cauchemez S, Reed C, Gambhir M, Finelli L. Estimates of the reproduction number for seasonal, pandemic, and zoonotic influenza: a systematic review of the literature. BMC Infect Dis 2014; 14: 480.

6. Jayasundara K, Soobiah C, Thommes E, Tricco AC, Chit A. Natural attack rate of influenza in unvaccinated children and adults: a meta regression analysis. BMC Infect Dis 2014; 14: 670.

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Published

2019-11-30

How to Cite

A Clinico-Hematological Study of Influenza Virus Infection . (2019). Academia Journal of Medicine, 2(2), 24–27. https://doi.org/10.48165/cqcff414