Clinical Outcome of Vitamin D Supplementation in Moderate and Severe COVID-19 Patients: A Randomized Clinical Trial

Authors

  • Sanket Agrawal SR Respiratory Medicine IGGMC& Mayo Hospital Nagpur, Prof& Head Respiratory Medicine Government Medical College, Nagpur, Psychiatrist Get-well Hospital Nagpur, Gastroenterologist, Bhopal, Resident Physician Department of Neurology, UAMS
  • Sushant Meshram SR Respiratory Medicine IGGMC& Mayo Hospital Nagpur, Prof& Head Respiratory Medicine Government Medical College, Nagpur, Psychiatrist Get-well Hospital Nagpur, Gastroenterologist, Bhopal, Resident Physician Department of Neurology, UAMS
  • Shruti Agrawal SR Respiratory Medicine IGGMC& Mayo Hospital Nagpur, Prof& Head Respiratory Medicine Government Medical College, Nagpur, Psychiatrist Get-well Hospital Nagpur, Gastroenterologist, Bhopal, Resident Physician Department of Neurology, UAMS
  • Kamlesh Taori SR Respiratory Medicine IGGMC& Mayo Hospital Nagpur, Prof& Head Respiratory Medicine Government Medical College, Nagpur, Psychiatrist Get-well Hospital Nagpur, Gastroenterologist, Bhopal, Resident Physician Department of Neurology, UAMS
  • Shubham Biyani SR Respiratory Medicine IGGMC& Mayo Hospital Nagpur, Prof& Head Respiratory Medicine Government Medical College, Nagpur, Psychiatrist Get-well Hospital Nagpur, Gastroenterologist, Bhopal, Resident Physician Department of Neurology, UAMS

DOI:

https://doi.org/10.48165/fvcefk77

Keywords:

COVID-19, Vitamin D, Supplementation, Clinical Outcomes, Randomized Clinical Trial, Tertiary Care Hospital, Inflammatory Markers, Steroid-Sparing Effect

Abstract

The COVID-19 pandemic has posed a major global health challenge, especially  for individuals with underlying health issues. This study aimed to assess the clin ical outcomes of vitamin D supplementation in patients with moderate to severe  COVID-19 in a tertiary care hospital through a randomized clinical trial. Sixty two SARS-CoV-2 positive patients were enrolled and divided into intervention  (vitamin D supplementation) and control groups. 

References

World Health Organization. (n.d.). Coronavirus disease (COVID 19) situation report. World Health Organization.

Holick, M. F. (2007). Vitamin D deficiency. New England Journal of Medicine, 357(3), 266–281. https://doi.org/10.1056/ NEJMra070553

Grant, W. B., Lahore, H., McDonnell, S. L., Baggerly, C. A., French, C. B., Aliano, J. L., & Bhattoa, H. P. (2020). Evidence that vitamin D supplementation could reduce the risk of influenza and COVID-19 infections and deaths. Nutrients, 12(4), 988. https://doi.org/10.3390/nu12040988

Dong, E., Du, H., & Gardner, L. (2020). An interactive web based dashboard to track COVID-19 in real time. Lancet Infectious Diseases, 20(5), 533–534. https://doi.org/10.1016/ S1473-3099(20)30120-1

Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., Qiu, Y., Wang, J., Liu, Y., Wei, Y., et al. (2020). Epidemiological and clinical characteristics of 99 cases of 2019 novel coro navirus pneumonia in Wuhan, China: A descriptive study. The Lancet, 395(10223), 507–513. https://doi.org/10.1016/ S0140-6736(20)30211-7

Yang, J., Zheng, Y., Gou, X., Pu, K., Chen, Z., Guo, Q., Ji, R., Wang, H., Wang, Y., & Zhou, Y.-N. (2020). Prevalence of comorbid ities and its effects in patients infected with SARS-CoV-2: A systematic review and meta-analysis. International Journal of Infectious Diseases, 94, 91–95. https://doi.org/10.1016/j. ijid.2020.03.017

Shi, Y., Yu, X., Zhao, H., Wang, H., Zhao, R., & Sheng, J. (2020). Host susceptibility to severe COVID-19 and establishment of a host risk score: Findings of 487 cases outside Wuhan. Critical Care, 24(1), 1–4. https://doi.org/10.1186/s13054-

020-2833-7

Mohan, M., Cherian, J. J., & Sharma, A. (2020). Exploring links between vitamin D deficiency and COVID-19. PLOS Pathogens. https://doi.org/10.1371/journal.ppat.1008874

Alvarez-Rodriguez, L., Lopez-Hoyos, M., Garcia-Unzueta, M., Amado, J. A., Cacho, P. M., & Martinez-Taboada, V. M. (2012). Age and low levels of circulating vitamin D are asso ciated with impaired innate immune function. Journal of Leukocyte Biology, 91(5), 829–838. https://doi.org/10.1189/ jlb.1011523

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Published

2024-07-30

Issue

Vol. 7 No. 2 (2024): Journals Academia Journal of Medicine (Jul- Dec)

Section

Research Article

How to Cite

Clinical Outcome of Vitamin D Supplementation in Moderate and Severe COVID-19 Patients: A Randomized Clinical Trial . (2024). Academia Journal of Medicine, 7(2), 24–26. https://doi.org/10.48165/fvcefk77