Management of a Maxillary Radicular Cyst in a Patient with Gilbert Syndrome: A Rare Case Report

Authors

  • Manjunath Shankariah Professor, Department of Oral and Maxillofacial Surgery, College of Dental Science, Davanagere, Karnataka-577004.
  • Gaganashree H G Postgraduate student, Department of Oral and Maxillofacial Surgery, College of Dental Science, Davanagere, Karnataka-577004.
  • Kiran Heggavadipura Yogendraswamy Professor, Department of Oral and Maxillofacial Surgery, College of Dental Science Davanagere, Karnataka-577004.
  • Harsha V Babaji Professor, Department of Oral and Maxillofacial Surgery, College of Dental Science Davanagere, Karnataka-577004.

DOI:

https://doi.org/10.48165/8ffcpx35

Keywords:

Gilbert syndrome, Radicular cyst, Perioperative management

Abstract

Gilbert syndrome is a rare benign autosomal genetic  disorder characterized by reduced activity of glucuronyl  transferase, leading to decreased clearance of bilirubin  and occasional mild jaundice in the absence of hepatic  injury or hemolysis. Diagnosis involves clinical and  laboratory investigations as part of differential diagnosis,  with genetic analysis providing additional confirmation.  Oral manifestations of Gilbert syndrome exist but often go  unnoticed. Drugs metabolized by this enzyme need to be  considered along with stress management in patients  undergoing surgical procedures. This case report of a 24- year-old male diagnosed with a radicular cyst in the  maxillary anterior teeth region, who incidentally exhibited  Gilbert syndrome, also highlights perioperative  management considerations for such patients. 

References

1. Owens D, Evans J. Population studies on Gilbert’s syndrome. J Med Genet. 1975 Jun;12(2):152–6.

2. Kamal S, Abdelhakam S, Ghoraba D, Massoud Y, Aziz KA, Hassan H, et al. The frequency, clinical course, and health related quality of life in adults with Gilbert’s syndrome: a longitudinal study. BMC Gastroenterol. 2019 Feb 4;19:22.

3. Gilbert Syndrome - Disease Symptoms, Causes, Treatment [Internet]. [cited 2024 Jun 24]. Available from: https://rarediseases.org/rare-diseases/gilbert syndrome/

4. Abbasi H, Lal A, Jouhar R. Oral Manifestations of a Patient Suffering from a Rare Gilbert’s Syndrome: A Case Report. J Islamabad Med Dent Coll. 2021 Sep 30;10.

5. Nag DS, Sinha N, Samaddar DP, Mahanty PR. General anesthesia in a patient with Gilbert’s syndrome. J Anaesthesiol Clin Pharmacol. 2011;27(2):253–5.

6. Idiopathic unconjugated hyperbilirubinemia (Gilbert’s syndrome). A study of 42 families - PubMed [Internet]. [cited 2024 Jun 24]. Available from: https://pubmed.ncbi.nlm.nih.gov/6054997/

7. Singh A, Koritala T, Jialal I. Unconjugated Hyperbilirubinemia. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 [cited 2024 Jun 24]. Available from: http://www.ncbi.nlm.nih.gov/books/NBK549796/

8. Horsfall LJ, Nazareth I, Pereira SP, Petersen I. Gilbert’s syndrome and the risk of death: a population-based cohort study. J Gastroenterol Hepatol. 2013 Oct;28(10):1643–7.

9. Quinn NW, Gollan JL. Jaundice following oral surgery: Gilbert’s syndrome. Br J Oral Surg. 1975 Mar;12(3):285–8.

10. Tzoneva D, Aleksiev E, Michova K, Stanimirov P. Perioperative management and anaesthetic considerations for adult patients with Gilbert’s syndrome and oral cancer: review and case report. Biotechnol Biotechnol Equip. 2019 Jan 1;33(1):1182–6.

11. Esteban A, Pérez-Mateo M. Heterogeneity of paracetamol metabolism in Gilbert’s syndrome. Eur J Drug Metab Pharmacokinet. 1999;24(1):9–13

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Published

2024-07-14

How to Cite

Management of a Maxillary Radicular Cyst in a Patient with Gilbert Syndrome: A Rare Case Report . (2024). Academia Journal of Medicine, 7(2), 1–7. https://doi.org/10.48165/8ffcpx35