Hair Growth Promoting Activity of  Zauberöl® in Testosterone-Induced  Alopecia in Wistar Rats

Satyendra Kumar Rajput; Monalisa Mukherjee; Harsha  Kharkwal; Snigdha Suman Dalua; Poorva Tiwari; Ramachandran Valavan

doi:10.48165/ahr.2023.8.2.1

Authors

Satyendra Kumar Rajput Department of PharmaceuticalSciences, Gurukula Kangri Haridwar, Uttarakhand
Monalisa Mukherjee Amity Institute of Click Chemistry Research and Studies, Amity University, Noida, Uttar Pradesh
Harsha Kharkwal Amity Institute of Phytochemistry and Phytomedicine, Amity University, Noida, Uttar Pradesh
Snigdha Suman Dalua Dr. Willmar Schwabe India Pvt. Ltd., A 36, Sector 60, Noida, India. Pin – 201304.
Poorva Tiwari Dr. Willmar Schwabe India Pvt. Ltd., A 36, Sector 60, Noida, India. Pin – 201304.
Ramachandran Valavan Dr. Willmar Schwabe India Pvt. Ltd., A 36, Sector 60, Noida, India. Pin – 201304.

DOI:

https://doi.org/10.48165/ahr.2023.8.2.1%20

Keywords:

Alopecia, Zauberӧl®, hair oil, hair fall

Abstract

Background: Hair loss, or alopecia, is a common disorder that affects between 0.2-2% of the world's population and have significant impacts on a person's mental and physical health. Normal hair loss on a healthy head is between 50 and 100 hairs a day. Alopecia is a disorder in which the follicles in certain people start losing hair prematurely because they are not healthy, increasing the pace at which hair falls. Alopecia can be caused by poor nutrition, chronic stress, genetics, or other factors, and there are several types, each with a unique cause and symptom. Apart from improving quality of life, using methods like hair treatments or transplants, many homeopathic herbal ingredients are reported useful in managing alopecia and hair fall. This study was aimed to investigate the effectiveness of a formulation Zauberӧl® containing Arnica montana, Ceanothus americanus, Eclipta prostrata, Hibiscus Rosa sinensis, Jaborandi, Murraya koenigii, Sabal serrulata & Thuja occidentalis in testosterone-induced alopecia in Wistar rats.

References

Reese, Cecil E., and Henry Eyring. “Mechanical properties and the structure of hair.” Textile Research Journal 20.11 (1950): 743-753.

Lavker, Robert M., et al. “Hair follicle stem cells.” Journal of Investigative Dermatology Symposium Proceedings. Vol. 8. No. 1. Elsevier, 2003.

Mounsey, Anne L., and Sean W. Reed. “Diagnosing and treating hair loss.” American family physician 80.4 (2009). 4. Hunt, N. and McHale, S., 2005. The psychological impact of alopecia. Bmj, 331(7522), pp.951-953.

Sperling LC. Hair and systemic disease. Dermatol Clin. 2001; 19: 711-26.

Insparya (2022) Types of alopecia: Insparya hair clinic, Clínica Capilar Madrid I Insparya. Available at: https:// insparya.es/typesalopecia/?lang=en#:~:text=There%20 are%20up%20to%206,at%20the%20age%20of%2050.

Dinh QQ, Sinclair R. Female pattern hair loss: current treatment concepts. Clin Interv Aging. 2007;2(2):189-199. 8. Mysore V, Parthasaradhi A, Kharkar RD, Ghoshal AK,

Ganjoo A, Ravichandran G, et al. Expert consensus on the management of Telogen Effluvium in India. Int J Trichology. 2019;11(6):236-244.

Avci P, Gupta GK, Clark J, Wikonkal N, Hamblin MR. Low level laser (light) therapy (LLLT) for treatment of hair loss. Lasers Surg Med. 2014;46(2):144-151.

W. Boericke, New Manual of Homoeopathic Materia Medica & Repertory [with Relationship of Remedies], Second Re Augmented & Revised Edition Based on Ninth Edition, Reprint Edition 2002, B. Jain Publishers, New Delhi.

J. H. Clarke, Dictionary of Practical Materia Medica, Reprint Edition 1992, B. Jain Publishers, New Delhi. 12. F. Schroyens, Synthesis Treasure Edition 2009V, RadarOpus 1.33 (Homoeopathic Software), Archibel S.A. Rue Fontaine St. Pierre 1E, Zoning Industriel de la Fagne, 5330 Assesse, Belgium.

Ross EK, Vincenzi C, Tosti A. Videodermoscopy in the evaluation of hair and scalp disorders. J Am Acad Dermatol. 2006;55(5):799-806.

Sinclair R. Aging hair. J Cosmet Dermatol. 2005;4(2):60- 72.

Hair loss - types of alopecia & causes of thinning hair (no date) WebMD. WebMD. Available at: https:// www.webmd.com/skin-problems-and-treatments/hair-loss/ understanding-hair-loss-basics.

Brannon, Maryland, Heather. “Anagen Phase” The New York Times. Retrieved 2007-11-14.

“Alopecia: Switch to herbal medicine - researchgate.”https://www.researchgate.net/profile/ KrishnAgrawal/publication/341755365_journal_of_ pharmaceutical_research_and_opinion_alopecia_switch_ to_herbal_medicine/links/5ed1f51b92851c9c5e6662c7/ journal-of-pharmaceutical-research-and-opinion-alopecia switch-to-herbal-medicine.Pdf.

Sudakov, Sergey K., et al. “Age-related individual behavioural characteristics of adult wistar rats.” Animals 11.8 (2021): 2282.

Fu, Danlan, et al. “Dihydrotestosterone-induced hair regrowth inhibition by activating androgen receptor in C57BL6 mice simulates androgenetic alopecia.” Biomedicine & Pharmacotherapy 137 (2021): 111247.

Gautam, S. A. P. N. A., et al. “Formulation and evaluation of herbal hair oil.” Int J Chem Sci 10.1 (2012): 349-53. 21. Joshi, Amol A. “Formulation and evaluation of polyherbal hair oil.” International Journal of Green Pharmacy (IJGP) 11.01 (2017).

Thammaiah Chethan, Ravindra YV, Sumana MN, Khanum F. Hair growth promoting activity of hibiscus rosa-sinensis. Journal of Ethnopharmacology. 2010; 124(3): 428-432.

Roy RK, Thakur M, Dixit VK. Development and evaluation of polyherbal formulation for hair growth-promoting activity. Journal of Cosmetic Dermatology. 2007; 6(2):108- 112.

Kang JS, Kim HN, Jung da J, et al. Effect of Murraya koenigii ethanol extract on hair growth promotion in C57BL/6 mice. Journal of Dermatological Science. 2014; 73(1): 41-48.

Choi SY, Kwon SH, Park SH, et al. Effects of saw palmetto extract and its constituents on 5-alpha-reductase activity in C6 cells and primary cultured cortical neurons. Journal of Investigative Dermatology. 2008; 128(4): 0123-0131.