Exploring the Role of Daphnin Glycoside in the Therapeutic Sphere of Mezereum: A Homoeopathic Perspective
DOI:
https://doi.org/10.48165/ahr.2026.11.2.5Keywords:
Mezereum, Daphnin, Glycoside, Homoeopathy, Coumarin, Law of Similars, Pharmacognosy, Therapeutic SphereAbstract
Daphne mezereum (commonly known as Mezereum or Spurge Olive) is a medicinal plant used both in traditional and Homoeopathic systems of medicine. Its chief active principle, Daphnin, is a coumarin glycoside responsible for many of the plant’s pharmacological and toxicological properties. This study explores the role of Daphnin glycoside in understanding the therapeutic sphere of Mezereum from a Homoeopathic perspective.
By reviewing chemical, toxicological, and Homoeopathic data, this paper aims to correlate the material basis of Daphnin with the dynamic action of the potentized drug. The irritant and vesicant effects of Daphnin correspond closely with Mezereum’s pathogenesis—marked by skin eruptions, neuralgias, and bone pains—thus validating the Law of Similars. The findings emphasize that scientific knowledge of the glycosidic components strengthens our understanding of Mezereum’s curative action, bridging the gap between modern pharmacology and Homoeopathic philosophy.
References
Boericke W. Pocket Manual of Homoeopathic Materia Medica. New Delhi: B. Jain Publishers; latest edition.
Allen TF. The Encyclopedia of Pure Materia Medica. New York: Boericke & Tafel; 1874.
Hering C. The Guiding Symptoms of Our Materia Medica. Philadelphia: American Homoeopathic Publishing Society; 1879.
Clarke JH. A Dictionary of Practical Materia Medica. London: The Homoeopathic Publishing Company; 1900.
Trease GE, Evans WC. Pharmacognosy. 16th ed. London: Saunders Elsevier; 2009.
Kokate CK, Purohit AP, Gokhale SB. Pharmacognosy. 49th ed. Pune: Nirali Prakashan; 2021.
Gupta AK. Quality Standards of Indian Medicinal Plants. Vol. 12. New Delhi: ICMR; 2014.
Duke JA. Handbook of Phytochemical Constituents of GRAS Herbs and Other Economic Plants. Boca Raton: CRC Press; 1992.
Vasil’eva IS, et al. Coumarin glycosides from the bark of Daphne mezereum. Chem Nat Compd. 1978;14(6):683–684.
Khare CP. Indian Medicinal Plants: An Illustrated Dictionary. Berlin: Springer; 2007.

