ESTIMATION OF ZINC CONTENT IN HUMAN LUNG AND LIVER AUTOPSY TISSUE SAMPLES: A STUDY ON THE POPULATION OF AJMER (INDIA)
DOI:
https://doi.org/10.48165/Keywords:
Autopsy, demographic profile, human, liver, lung, zincAbstract
Zinc (Zn) is an important element in human biological system. Human autopsy wet tissues (67) of lungs and liver, collected at random from Ajmer population of Rajasthan (India), were analyzed for Zn content. The samples were taken from non-putrefied dead bodies received at JLN Medical College (JLNMC), Ajmer. The samples from human undergone death due to burn injury or drowning were not considered. Seven demographic data for each case were collected from their medical status reports (post-mortem report) and from the pathological and anatomical reports available at the Forensic Medicine Department, JLNMC and also from the relatives of sampled human cases. Fresh autopsy tissues were digested in di-acid and analyzed by graphite furnace atomic absorption spectrometry. In lungs and liver, the average Zn content was 26.4 and 46.1 µg g-1, respectively. The Zn content in lungs and liver samples varied from 11.59 to 97.51 and 26.63 to 114.29 µg g-1, respectively. In females the mean Zn levels were higher than males in both lung and liver. Rural residents had higher mean Zn content than peri-urban and urban residents. In occupation environment sub-group exposed to polluted area had low mean Zn content than non-exposed cases.
Downloads
References
Akhtar, S. 2013. Zinc status in South Asian population, An update. Journal of Health, Population and Nutrition, 31(2): 139-149.
Benes, B., Jakubec, K., Simid, J. and Spevackova, V. 2002. Determination of thirty two elements in human autopsy tissues. Biological Trace Element Research, 75: 195-203.
Bode, J.C., Hanisch, P., Henning, H., Koenig, W., Richter, F.W. and Bode, C. 1988. Hepatic zinc content in patient with various stage of alcoholic liver disease and patient with chronic active and chronic persistent hepatitis. Hepatology, 8(6): 1605-1609.
Caroli, S., Alimonti, A., Coni, E., Petrucci, F., Senofonte, O. and Violante, N. 1994. The assessment of reference values for elements in human biological tissues and fluids. Critical Reviews in Analytical Chemistry, 24(5 & 6): 363-398.
Chasapis, C.T., Ntoupa, P.A., Spiliopoulou, C.A. and Maria, E.S. 2020. Recent aspects of the effects of zinc on human health. Archives of Toxicology, 94: 1443-1460.
FAO. 2004. Expert Consultation on Human Vitamin and Mineral Requirements, Vitamin and Mineral Requirements in Human Nutrition. Report of Joint FAO/WHO Expert Consolation, Food and Nutrition Division, FAO, Rome, Italy.
Khan, F. and Dutta, S. 2015. Occupational toxicity of copper and their implications on industrial workers of Ajmer city, Rajasthan, India. Journal of Environmental Research and Development, 9(3A): 833-839.
Khazen, R.R., Bolann, B.J., Myking, A. and Ulvik, R.J. 2002. Multi-element analysis of trace element levels in human autopsy tissues by using ICP-AES. Journal of Trace Elements in Medical Biology, 16: 15-25.
Kavita Kumari et al.
Kumari, K. and Tak, R.K. 2018. Biomonitoring in humans for determination of elemental load on body: A mini review of research work done in Rajasthan State. The Pharma Innovation Journal, 7(4): 379-380.
Mehra, R. and Juneja, M. 2004. Biological monitoring of lead and cadmium in human hairs and nails and their correlations with biopsy material, age and exposure. Indian Journal of Biochemistry and Biophysics, 41: 53-56.
Mehra, R. and Thakur, A.S. 2016. Relationship between lead, cadmium, zinc, manganese and iron in hair of environmentally exposed subjects. Arabian Journal of Chemistry, 9(2): 1214-1217. Mehra, R. and Thakur, A.S. 2010. Assessment of metal hazard taking hairs as an indicator of trace element exposure to workers in occupational environment. Journal of Elementology, 15(4): 671-678.
Prasad, A.S. 2013. Discovery of human zinc deficiency: Its impact on human health and disease. Advance in Nutrition, 4: 176-190.
Rahil, K.R., Bolann, B.J. and Ulvik, R.J. 2000. Trace element reference values in serum determined by inductively coupled plasma atomic emission spectrometry. Clinical Chemistry and Laboratory Medicine, 38: 765-772.
Robson, M. 2003. Methodologies for assessing exposure to metals: human host factors. Ecotonical and Environmental Safety,56: 104-109.
Singh, M.V., Narwal, R.P.G. and Bhupal, R. 2009. Changing scenario of micronutrient deficiencies in India during four decades and its impact on crop responses and nutritional health of human and animals. In: The Proceedings of the International Plant Nutrition Colloquium XVI. Department of Plant Sciences, University of California, California, USA. (https://escholarship.org/uc/item/7g5667d9).
Teresa, Lech and Danuta, D.A. 2009. Concentration of zinc and manganese in post-mortem tissues and body fluids. Problems of Forensic Sciences, 78: 226-238.
Yoo, Y.C., Lee, S.K., Yang, J.Y., Whan, I.S., Kim, W. and Choung S.Y. 2002. Organ distribution of heavy metals in autopsy material from Normal Korean. Journal of Health Science, 48(2): 186-194.
Zakas, N.P., Soboleva, S.E. and Nevinsky, G.A. 2019. Twenty elements concentration in human organs determined by two jet plasma atomic emission spectrometry. The Scientific World Journal, 2019: 9 [https://doi.org/10.1155/2019/9782635].