ISCHEMIA-MODIFIED ALBUMIN LEVELS AND DYNAMIC THIOL/  DISULFIDE BALANCE IN FEMALE PATIENTS WITH IRON  DEFICIENCY ANEMIA

Emre Avcı; Alpaslan Karabulut; Gülçin Alp Avcı; Cigdem Cicek; Cumhur Bilgi

doi:10.48165/

Authors

Emre Avcı University of Health Sciences, Gulhane Faculty of Pharmacy, Department of Biochemistry, Ankara (Turkey)
Alpaslan Karabulut Hitit University, Faculty of Medicine, Department of Internal Medicine, Corum (Turkey)
Gülçin Alp Avcı University of Health Sciences, Gulhane Faculty of Dentistry, Department of Basic Medical Science, Ankara (Turkey)
Cigdem Cicek üksek İhtisas University, Faculty of Medicine, Department of Medical Biochemistry, Ankara (Turkey)
Cumhur Bilgi Yüksek İhtisas University, Faculty of Medicine, Department of Medical Biochemistry, Ankara (Turkey)

DOI:

https://doi.org/10.48165/

Keywords:

Iron deficiency anemia, ischemia-modified albumin, oxidative stress, thiol/disulfide homeostasis

Abstract

Iron deficiency anemia (IDA) affects about 20-30% of adults worldwide. The present study was aimed to determine the relationship between ischemia-modified albumin (IMA) and dynamic thiol/disulfide balance in female patients with IDA, and to reveal its effects on the development of anemia and the organism. The study included a total of 88 individuals (48 patients/ 40 healthy). IMA levels and disulfide/thiol homeostasis were measured by colorimetric and spectrophotometric methods. Total thiol (TTL) levels were found significantly positively correlated with native thiol (NTL) values (r = 0.326, p<0.05). A strong positive correlation was found between TTL and disulfide (r = 0.511, p<0.01). A negative correlation was observed between NTL and disulfide (r = -0.546, p<0.05) and between TTL and IMA (r = -0.160, p>0.05); but weak negative correlation was found between NTL and IMA (r = -0.011, p<0.05) and between IMA and disulfide (r = -0.035, p<0.05). The progression of this iron deficiency anemia is a risk factor for the occurrence of many diseases. Therefore, it is important to evaluate the parameters together in relation to the prognosis of hypoxic state and oxidant balance caused by anemia.

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