FIRST TRIMESTER URIC ACID LEVEL -A RISK FACTOR FOR GESTATIONAL DIABETES MELLITUS AND HYPOTHYOIDISM

V   Sathya; S Vasanth S; Sumathi   Jones; G Bupesh

doi:10.48165/abr.2024.26.01.36

Authors

V Sathya Department of Research & Development, Department of Biochemistry, Karpaga Vinayaga Institute of Medical Science and Research Centre, Chengalpattu - 603 308, Tamil Nadu (India)
S Vasanth S R&D Wing, Sree Balaji Medical College and Hospital, Bharath Institute of Higher Education and Research, Chennai - 600 044, Tamil Nadu (India)
Sumathi Jones Department of Pharmacology and Therapeutics, Sree Balaji Dental College and Hospital, BIHER, Chennai – 600 100, Tamil Nadu (India)
G Bupesh Department of Forestry, Nagaland University, Zunheboto - 798 627, Nagaland (India)

DOI:

https://doi.org/10.48165/abr.2024.26.01.36

Keywords:

Gestational diabetes mellitus, glucose challenge test, pregnancy, subclinical hypothyroidism, uric acid

Abstract

Aim: To investigate the relationship between serum Uric acid concentration, gestational diabetes mellitus and to check the changes in thyroid hormone status with increased gestational age. Pregnant women with elevated uric acid levels are experiencing a higher occurrence of pregnancy complications like gestational diabetes mellitus (GDM) and sub clinical hypothyroidism.Materials and methods: About 50 non diabetic, Euthyroid pregnant women had participated in our study and 1^st trimester Uric acid level was checked. Subsequently, all the pregnant women were continuously followed and OGCT, FT4, TSH was performed between 24-28 weeks of gestation.Results: Our study revealed a direct relationship between Glucose Challenge Test (GCT) results and serum uric acid levels, employing a threshold of more than 4.6mg/dl (p value <0.017). The uric acid concentration in maternal serum emerges as a dependable indicator of gestational diabetes mellitus in the initial phases of pregnancy. Additionally, our study also revealed an interconnection between uric acid concentration, Glucose metabolism and thyroid hormones concentration (p value <0.0001), with advancing gestational age.

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Author Biography

Sumathi Jones, Department of Pharmacology and Therapeutics, Sree Balaji Dental College and Hospital, BIHER, Chennai – 600 100, Tamil Nadu (India)

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