MOLECULAR DOCKING OF BREAST CANCER RECEPTORS AGAINST  ANTI-CANCER DRUG SOLASODINE

B  Gopal Samy; S Karthika Devi; J Priya Dharshini

doi:10.48165/abr.2024.26.01.8

Authors

B Gopal Samy Department of Biotechnology, VSB Engineering College (Autonomous), Karur-639111, Tamil Nadu (India)
S Karthika Devi Department of Biotechnology, VSB Engineering College (Autonomous), Karur-639111, Tamil Nadu (India)
J Priya Dharshini Department of Biotechnology, VSB Engineering College (Autonomous), Karur-639111, Tamil Nadu (India)

DOI:

https://doi.org/10.48165/abr.2024.26.01.8

Keywords:

Autodock, breast cancer, discovery studio, Farnesoid x receptor, molecular docking, solasodine

Abstract

Cancer is a deadly disease that occurs in skin, pancreas, breast, and other body

parts. Breast cancer is nowadays more common and can develop from various

cell lines like MCF-7, MDA-MB-231, BT-20, etc. Early diagnosis and treatment

can reduce the frequency of fatalities due to breast cancer, but early cancer

screenings are often postponed due to erroneous information, fear, and

ignorance. In the present work, we used molecular docking to find out the

effect of solasodine binding on different cancer receptors. Solasodine was

extracted from black nightshade (Solanum nigrum), a weed that was long used

against stomach ache in Ayurveda. The isolated solasodine was even used in

ointments against skin cancer. Docking such a medicinally potent compound

resulted in positive response against a few receptors like Farnesoid X,

epidermal growth factor receptor and progesterone receptor. MCF-7 breast

cancer cell line was chosen for further ex-vivo studies and the results of MTT

assay showed significant anti-cancer effects at solasodine concentrations of 500

and 1000 µg mL-1. These findings indicated that Solasodine was a vital

candidate as drug against breast cancer.

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