Haemato-Biochemical Alterations In Induced  Chlorpyrifos Toxicity In Broiler Chickens

Henna Wani; Shafiqur Rahman; Shagufta Azmi; Mudasir Sultana; Navdeep Kour; Amit Khajuria

doi:10.48165/

Authors

Henna Wani Division of Veterinary Pathology, Faculty of Veterinary Sciences and Animal Husbandry, SK University of Agricultural Sciences and Technology of Jammu, R.S. Pura, Jammu – 181102, Jammu & Kashmir (India)
Shafiqur Rahman Division of Veterinary Pathology,Faculty of Veterinary Sciences and Animal Husbandry, SK University of Agricultural Sciences and Technology of Jammu, R.S. Pura, Jammu – 181102, Jammu & Kashmir (India)
Shagufta Azmi Division of Veterinary Pathology,Faculty of Veterinary Sciences and Animal Husbandry, SK University of Agricultural Sciences and Technology of Jammu, R.S. Pura, Jammu – 181102, Jammu & Kashmir (India)
Mudasir Sultana Division of Veterinary Pharmacology & Toxicology, Faculty of Veterinary Sciences and Animal Husbandry, SK University of Agricultural Sciences and Technology of Jammu, R.S. Pura, Jammu – 181102, Jammu & Kashmir (India)
Navdeep Kour Division of Veterinary Pathology, Faculty of Veterinary Sciences and Animal Husbandry, SK University of Agricultural Sciences and Technology of Jammu, R.S. Pura, Jammu – 181102, Jammu & Kashmir (India)
Amit Khajuria Division of Veterinary Pathology, Faculty of Veterinary Sciences and Animal Husbandry, SK University of Agricultural Sciences and Technology of Jammu, R.S. Pura, Jammu – 181102, Jammu & Kashmir (India)

DOI:

https://doi.org/10.48165/

Keywords:

Broiler chicken, chlorpyrifos, hematology, serum biochemistry

Abstract

Effect of graded doses of chlorpyrifos on haemato-biochemical indices in broiler chickens was investigated. A total of 72 broiler chickens, 3 week old, were divided into four groups (I to IV) consisting of 18 birds each. Group I served as control, whereas groups II, III and IV received 3.2, 1.6 and 0.6 mg kg-1 B.W. chlorpyrifos in corn oil daily for 6 weeks. Blood samples were collected in sterile vials containing EDTA (@ 1 mg mL-1) as anticoagulant for haematological studies and without anticoagulant for biochemical parameters. Mean values of Hb, PCV, TEC, MCV, MCH, MCHC, TLC and lymphocyte counts decreased significantly in all the treatment groups, whereas platelet count increased significantly. Serum total protein, albumin and A:G ratio showed decrease, whereas serum ALT, AST, RBC acetyl cholinesterase and butryl-cholinesterase activities exhibited increase. The study revealed that chlorpyriphos has haemotoxic, immune-toxic, hepatotoxic, nephrotoxic and neurotoxic effects in broiler chickens.

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