Recent Progress In Biotechnological Interventions In  Piper Species: A Review

Gyana Ranjan Rout; Kirath Singh; Tapaswini Hota; Jogeswar Panigrahi; Gyanalok Das

doi:10.48165/

Authors

Gyana Ranjan Rout Department of Agricultural Biotechnology, College of Agriculture, Orissa University of Agriculture & Technology, Bhubaneswar - 751015, Odisha (India)
Kirath Singh Department of Agricultural Biotechnology, College of Agriculture, Orissa University of Agriculture & Technology, Bhubaneswar - 751015, Odisha (India)
Tapaswini Hota Department of Agricultural Biotechnology, College of Agriculture, Orissa University of Agriculture & Technology, Bhubaneswar - 751015, Odisha (India)
Jogeswar Panigrahi Department of Life Sciences, Sambalpur University, Burla, Sambalpur, Odisha (India).
Gyanalok Das High Altitute Research Station, Patangi, Koraput, Odisha (India)

DOI:

https://doi.org/10.48165/

Keywords:

Antimicrobial properties, genetic diversity, Piper species, secondary metabolites, genetic engineering

Abstract

Medicinal plants have tremendous potential for the development of new drugs molecule effective against various diseases. Genus Piper is the largest genus in family Piperaceae and indigenous to India with one of the most widely used spice in the world. Biotechnological innovations in Piper species have lead to the development of plant-derived molecules which exhibit a promising effect in therapeutics. The present paper reviews the genetic diversity analysis of major Piper species through DNA markers, to establish in vitro protocol for mass multiplication of elite clone of different species, phytochemical compounds extracted in various solvent systems in Piper species and comparative analysis of active compounds associated with Piper species through HPTLC analysis as well as testing their antimicrobial activities. The activity has been tested against bacteria like E. coli, Micrococcus luteus, Streptomyces epidermidis, etc. and fungi like Aspergillus niger, A. flavus and Rhizoctonia solani using agar well diffusion method. The review also highlights the use of in vitro strategy in genetic manipulation of transgenic traits using specific promoters to accomplish high tissue specific protein production and overcome biotic stresses.

Downloads

Download data is not yet available.

References

bbasi, B.H., Ahmad, N., Fazal, H. and Mahmood , T. 2010. Conventional and modern propagation activity. Journal of Ethnopharmacology, 70: 343-349.

Agarwal, T., Singh, R., Shukla, A.D., Waris, I. and Gujrati, A. 2012. Comparative analysis of antibacterial activity of four Piper betle varieties. Advances in Applied Science Research, 3: 698-705.

Ahmad, N., Abbasi, B.H., Rahman, I. and Fazal, H. 2013. Piper nigrum: Micropropagation, antioxidative enzyme activities, and chromatographic fingerprint analysis for quality control. Applied Biochemistry and Biotechnology, 169: 204-215.

Biotechnology of Piper species 103

Alex, S.M., Dicto, J., Purushothama, M.G., and Manjula, S. 2008. Differential expression of metallothionein type-2 homologues in leaves and roots of black pepper (Piper nigrum L.) Genetics and Molecular Biology, 31: 551-554.

Anand, A. and Rao, C.S. 2000. A rapid in vitro propagation protocol for Piper barberi gamble. A critically endangered plant. In vitro Cellular and Developmental Biology - Plant, 36: 61-64. Anupama, K., Cyriac, A., Saji, K.V. and Nirmal Babu, K. 2015. Microsatellite marker based cross species amplification and genetic diversity analysis in the genus piper. International Journal of Advanced Research, 3: 184-191.

Babu, N.K., Lukose, R. and Ravindran, P.N. 1993. Tissue culture of tropical spices. pp. 257-267. In: Proceedings of International Symposium on Genetic Engineering and Tissue Culture for Crop Pest and Disease Management (ed. Vidhyasekharan). Daya Publishing House, New Delhi, India.

Bajad, S., Bedi, K.L., Singla, A.K. and Johri, R.K. 2001. Antidiarrhoeal activity of piperine in mice. Planta Medica, 67: 284-287.

Bhat, S.R., Chandel, K.P.S. and Malik, S.K. 1995. Plant regeneration from various explants of cultivated Piper species. Plant Cell Reports, 14: 398-402.

Bourgaud, F., Gravot, A., Milesi, S. and Gontier, E. 2001. Production of plant secondary metabolites: A historical perspective. Plant Science, 161: 839-851.

Cheng, Y.Q., Xia, N.H. and Gilbert, M.G. 1999. Piperaceae. pp. 110-131. In: Flora of China Vol. 4. (eds. Z. Wu and P.H. Raven), Beijing Science Press, St Louis, USA.

Chowdhury, U., Tanti, B., Rethy, P. and Gajurel, P.R. 2014. Analysis of genetic diversity of certain species of Piper using RAPD-based molecular markers. Applied Biochemistry and Biotechnology, 174: 168-173.

El Hamas, R., Idaomar, M., Alonso-Moraga, A. and Muñoz, S.A. 2003. Antimutagenic properties of bell and black pepper. Food and Chemical Toxicology, 41: 41-47.

Essawi, T. and Srour, M. 2000. Screening of some Palestinian medicinal plants for antibacterial Garcia-Hernandez, M., Murphy, A. and Taiz, L. 1998. Metallo-thioneins 1 and 2 have distinct but overlapping expression patterns in Arabidopsis. Plant Physiology, 118: 387-397. Gulcin, I. 2005. The antioxidant and radical scavenging activities of black pepper seeds. International Journal of Food Science and Nutrition, 56: 491-499.

its antiproliferative activity. African Journal of Pharmacy and Pharmacology, 4: 562-573. Jiang, Y. and Liu, J.P. 2011. Analysis of genetic diversity of Piper spp. in Hainan island (China) using inter-simple sequence repeat ISSR markers. African Journal of Biotechnology, 10: 14731-14737.

Joseph, L., Nazeem, P.A., Thampi, M.S., Philip, S. and Balachandran, M. 1996. In vitro techniques for mass multiplication of black pepper (Piper nigrum L.) and ex vitro performance of the plantlets. Journal of Plant Breeding and Crop Science, 24: 511-516.

Joy, N, Abraham, Z. and Soniya E.V. 2007. A preliminary assessment of genetic relationships among agronomically important cultivars of black pepper. BMC Genetics, 8: 42. Krishnakumar, S., Geetha, V.S. and Kuruvilla, A. 2001. Determination of local anesthetic action of betel leaf extract alone and with betel nut using infiltration and surface anesthesia. Journal of Natural Remedies, 1: 28-32.

Lee, S.A., Hong, S.S., Han, X.H., Hwang, J.S., Oh, G.J., Lee, K.S., Lee M.K., Hwang B.Y. and Ro, J.S. 2005. Piperine from the fruits of Piper longum with inhibitory effect on monoamine oxidase and antidepressant-like activity. Chemical and Pharmaceutical Bulletin (Tokyo), 53: 832.-835.

Lupina, T. and Cripps, H. 1987. The photo isomers of Piperine. Journal of Analytical Chemistry, 70: 112-113.

Mathews, V.H. and Rao P.S. 1984. In vitro responses in black pepper (Piper nigrum). Current Science, 53: 183-186.

Gyana Ranjan Rout et al.

Menon, A.N., Padmakumari, K.P. and Jayaleksmy, A. 2003. Essential oil composition of four major cultivars of black pepper (Piper nigrum L.). III. Journal of Essential Oil Research, 15: 155-157.

Menon, A.N., Padmakumari, K.P., Jayaleksmy, A., Gopalakrishnan, M. and Narayanan, C.S. 2000. Essential oil composition of four popular Indian cultivars of black pepper (Piper nigrum L.). Journal of Essential Oil Research, 12: 431-434.

Mishra, R.K. and Singh, S.K. 2009. Antispermatogenic and antifertility effects of fruits of Piper nigrum L. in mice. Indian Journal of Experimental Biology, 47: 706-714.

Murashige, T. and Skoog, F. 1962. A revised medium for rapid growth and bioassays with tobacco tissue cultures. Plant Physiology, 15: 473-497.

Nair, R.R. and Gupta, S.D. 2003. Somatic embryogenesis and plant regeneration in black pepper (Piper nigrum L.). Journal of Horticultural Science and Biotechnology, 78: 416-421. Nair, R.R. and Gupta, S.D. 2005. Effect of explants and genotype on primary somatic embryogenesis in black pepper (Piper nigrum L.). Cytologia, 70: 195-202.

Nair, R.R. and Gupta, S.D. 2006. High frequency plant regeneration through cyclic secondary somatic embryogenesis in black pepper (Piper nigrum L.) Plant Cell Reports, 24: 699-707. Nazeem, P.A., Joseph, L., Geetha, C.K. and Nair, G.S. 1992. In vitro cloning of black pepper (Piper nigrum L.). Journal of Plantation Crop, 20: 257-259.

Ozkuthu, F., Sekeroglu, N. and Kara, S.M. 2006. Monitoring of cadmium and micronutrients in spices commonly consumed in Turkey. Research Journal of Agriculture and Biological Sciences, 2: 223-226.

Parmar, V.S., Jain, S.C., Bisht, K.S., Jain, R., Taneja, P., Jha, A., Tyagi, O.D., Prasad, A.K., Wenge, l.J., Olsen, C.E. and Boll, P.M. 1997. Phytochemistry of the genus Piper. Phytochemistry, 46: 597-673.

Pathak, N. and Khandelwal, S. 2009. Immuno-momodulatory role of piperine in cadmium induced thymic atrophy and splenomegaly in mice. Environmental Toxicology and Pharmacology, 28: 52-60.

Pathak, N. and Khandlewal, S. 2007. Cytoprotective and immunomodulating properties of piperine on murine splinocytes: An in vitro study. European Journal of Pharmacology, 576: 160. Philip, V.J., Joseph, D., Triggs, G.S. and Dickinson, N.M. 1992 Micropropagation of black pepper

(Piper nigrum L) through shoot tip culture. Plant Cell Reports, 12: 41-44. Pradeepkumar, T., Karihaloo, J.L., Archak, S. and Baldev, A. 2003. Analysis of genetic diversity in Piper nigrum L. using RAPD markers. Genetic Resources and Crop Evolution, 50: 469-475.

Rahiman, B.A. and Nair, M.K. 1983. Morphology, cytology and chemical constituents of some Piper species from India. Journal of Plantation Crop, 11: 72-90.

Reshmi, S.K., Sathya, E. and Suganya Devi, P. 2010. Isolation of piperdine from Piper nigrum and Rout, G.R., Samantary, S. and Das, P. 2000. In vitro manipulation and propagation of medicinal plants. Biotechnology Advances, 18: 91-120.

Rubluo, A. and Barroso, A.L. 1992. In vitro morphogenetic responses and cytokinin-auxin interaction for callus production in pepper. Anales del Instituto de Biologia Universidad Nacional Autonoma de Mexico Serie Botanica, 63: 195-201.

Saraf, A. and Saraf, A. 2013. Phytochemical and antimicrobial studies of medicinal plant Piper longum Linn. International Journal of Pharmacognosy and Phytochemical Research, 6: 213- 222.

Sasikumar, B. and Veluthambi, K. 1996. Transformation of black pepper (Piper nigrum L.) using Agrobacterium mediated Ti plasmid based vectors. Indian Perfumer, 40: 13-16. Scott, D. and Albert, L.L. 2005. Maize metallothionein promoter. Patent Publication Number. WO/2005/063997.

Scott, I.M., Jensen, H.R., Philogene, B.J.R. and Arnason, J.T. 2008. A review of Piper spp. (Piperaceae): Phytochemistry, insecticidal activity and mode of action. Phytochemistry Review, 7: 65-75.

Biotechnology of Piper species 105

Sencie-Tarazona, A., Rojas-Idrogo, C., Kato, M.J. and Delgado-Paredes, G.E. 2015. In vitro rapid clonal propagation in static liquid medium and acclimatization of Piper solmsianum and P. tuberculatum. International Journal of Pure and Applied Bioscience, 3: 1-10.

Sherwin, W.B. and Moritz, C. 2000. Managing and monitoring genetic erosion. pp. 9-34. In: Genetics, Demography and Viability of Fragmented Populations. (eds. A.G. Youn and G.M. Clarke), Cambridge Press, United Kingdom.

Singburaudom, N. 2015. Hydroxychavicol from piper betel leave is an antifungal activity against plant pathogenic fungi. Journal of Bioscience, 8: 82-92.

Singh, A., Kala, S., Kapoor, D.N., Gupta, R., Virk, A., Singh S. and Chaudhary, J. 2011. Effect on human sperm mitochondrial activity by Piper betle and Calendula officinalis. Annals of Biological Research, 2: 622-627.

Sujatha, R., Babu L.C. and Nazeem, P.A. 2003. Histological of organogenesis from callus cultures of black pepper (Piper nigrum L.). Journal of Tropical Agriculture, 41: 16-19. Sunila, E.S. and Kuttan, G. 2004. Immunomodulatory and antitumor activity of Piper longum Linn. and piperine. Journal of Ethnopharmacology, 90: 339-346.

techniques in Piper nigrum. Journal of Medicinal Plants Research, 4: 7-12. Thomas, T.V., Rema Shree, A.B., Nabeesa, E., Neelakandan, N. and Nandakumar, S. 2003. In vitro propagation of Terminalia arjuna Roxb. A multipurpose tree. Plant Cell Biotechnology and Molecular Biology, 4: 95-98.

Uysal, H., Fu, Y.B., Kurt, O., Peterson, G.W., Diederichsen, A. and Kusters, P. 2010. Genetic diversity of cultivated flax (Linum usitatissimum L.) and its wild progenitor pale flax (Linum bienne Mill.) as revealed by ISSR markers. Genetic Resources and Crop Evolution, 57: 1109- 1119.

Varghese, J.M. and Bhat, A.I. 2011. An efficient Agrobacterium-mediated transformation protocol for black pepper (Piper nigrum L.) using embryogenic mass as explant. Journal of Crop Science and Biotechnology, 14: 247-254.

Wang, W., Gan, S. and Wagnaer, G.J. 2002. Isolation and characterization of the CYP71D16 trichome-specific promoter from Nicotiana tabacum L. Journal of Experimental Botany, 53: 1891-1897.

Zhang, L.J. and Dai, S.L. 2010. Genetic variation within and among populations of Orychophragmus violaceus (Cruciferae) in China as detected by ISSR analysis. Genetic Resources and Crop Evolution, 57: 55-64.