Propanil-Induced Neurotoxicity In Freshwater Common  Carp (Cyprinus Carpio)

Muneeb U Rehman; Bilal Ahmad; Manzoor ur Rahman Mir; Rayeesa Ali; Showkat Ahmad Bhat; Adil Farooq; Mohammed Yaseen Shah; Sheikh Bilal Ahmad

doi:10.48165/

Authors

Muneeb U Rehman Molecular Biology Lab., Division of Veterinary Biochemistry, Faculty of Veterinary Sciences & Animal Husbandry, S.K. University of Agricultural Science & Technology of Kashmir, Srinagar – 190 006, Jammu & Kashmir (India)
Bilal Ahmad Molecular Biology Lab., Division of Veterinary Biochemistry, Faculty of Veterinary Sciences & Animal Husbandry, S.K. University of Agricultural Science & Technology of Kashmir, Srinagar – 190 006, Jammu & Kashmir (India)
Manzoor ur Rahman Mir Molecular Biology Lab., Division of Veterinary Biochemistry, Faculty of Veterinary Sciences & Animal Husbandry, S.K. University of Agricultural Science & Technology of Kashmir, Srinagar – 190 006, Jammu & Kashmir (India)
Rayeesa Ali Division of Veterinary Pathology, Faculty of Veterinary Sciences & Animal Husbandry, S.K. University of Agricultural Science & Technology of Kashmir, Srinagar – 190 006, Jammu & Kashmir (India)
Showkat Ahmad Bhat Molecular Biology Lab., Division of Veterinary Biochemistry,Faculty of Veterinary Sciences & Animal Husbandry, S.K. University of Agricultural Science & Technology of Kashmir, Srinagar – 190 006, Jammu & Kashmir (India)
Adil Farooq Department of Pharmaceutical Sciences, University of Kashmir, Hazratbal, Srinagar, J &K (India)
Mohammed Yaseen Shah Division of Veterinary Pathology, Faculty of Veterinary Sciences & Animal Husbandry, S.K. University of Agricultural Science & Technology of Kashmir, Srinagar – 190 006, Jammu & Kashmir (India)
Sheikh Bilal Ahmad Molecular Biology Lab., Division of Veterinary Biochemistry, Faculty of Veterinary Sciences & Animal Husbandry, S.K. University of Agricultural Science & Technology of Kashmir, Srinagar – 190 006, Jammu & Kashmir (India)

DOI:

https://doi.org/10.48165/

Keywords:

Antioxidant, Cyprinus carpio, herbicide, neurotransmitter, propanil

Abstract

Herbicides are known to affect the metabolic parameters in fishes. For this reason a study was designed to assess the effects of herbicide propanil (3',4'- dichloropropionanilide) on common carp (Cyprinus carpio L.) through antioxidant indices and other neurotoxicological parameters. Fishes were exposed to two concentration of propanil (2 and 4 mg L-1) for 6 and 48 h and effects on neurtoxicity biomarkers [acetylcholinesterase (AChE), Na+/K+- ATPase] and oxidative stress parameters [reduced glutathione levels, superoxide dismutase, catalase, thiobarbituric acid reactive substances and protein oxidation (protein carbonyl) were studied. Study revealed that propanil exposure disturbed antioxidant status, increased lipid peroxidation and protein carbonyl levels in fishes at both doses. Activity of neurotoxicity enzymes AChE and Na+/K+-ATPase was inhibited at both the doses of propanil exposure. Propanil was more toxic at higher doses at both the lengths of exposure.

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