Prophylactic Effect Of Vitamin E On Carmoisine Food Dye  Induced Kidney Damage In Male Mice: Histological,  Physiological And Immunological Studies

Amal A E Ibrahim; Sally A El-Sherbeny; Turki M Al-Shaikh

doi:10.48165/

Authors

Amal A E Ibrahim Faculty of Women for Arts, Education & Science, Ain Shams University, Cairo (Egypt)
Sally A El-Sherbeny Faculty of Science for Girls, Northern Border University, Ar'ar (Kingdom of Saudi Arabia)
Turki M Al-Shaikh Department of Biology, College of Science and Arts, Khulis, University of Jeddah (Kingdom of Saudi Arabia)

DOI:

https://doi.org/10.48165/

Keywords:

Antioxidant, carmoisine, mice, nephrotoxicity, vitamin E

Abstract

The study evaluates the immunomodulatory effect of vitamin E against the side effect of synthetic food dye-induced oxidative damage and nephrotoxicity in male mice. Mice were divided into 4 groups viz., group 1 as control mice, group 2 received vitamin E (100 mg kg-1 bw), group 3 administered with carmoisine (250 mg kg-1 bw), and group 4 received carmoisine and vitamin E for 28 days. Nephrotoxicity induce in mice was assessed by observing the changes in levels of renal markers, and antioxidant status. Administration of vitamin E significantly restored the levels of renal functions (urea and creatinine), antioxidants status and immunological parameters (TNF-a, Cox-2, Bcl-2, CD95 and caspase 3). The prophylactic role of vitamin E against food dye-induced toxicity may be attributed to their antioxidant effects and free radical scavenging properties.

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References

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