Innovative Approaches To Enhance Gastric Retention Of  Rabeprazole Using Macrocystis Pyrifera Extract

Pynskhemlin Syiemlieh; K S Srilatha; Hindustan Abdul Ahad; Chrishmitha Sequeira; Becare Dkhar; John Mithi

doi:10.48165/

Authors

Pynskhemlin Syiemlieh Department of Pharmaceutics, R.R College of Pharmacy, Bangalore – 560 090, Karnataka (India)
K S Srilatha Department of Pharmaceutics, R.R College of Pharmacy, Bangalore – 560 090, Karnataka (India)
Hindustan Abdul Ahad Department of Pharmaceutics, R.R College of Pharmacy, Bangalore – 560 090, Karnataka (India)
Chrishmitha Sequeira Department of Pharmaceutics, R.R College of Pharmacy, Bangalore – 560 090, Karnataka (India)
Becare Dkhar Department of Pharmaceutics, R.R College of Pharmacy, Bangalore – 560 090, Karnataka (India)
John Mithi Department of Pharmaceutics, R.R College of Pharmacy, Bangalore – 560 090, Karnataka (India)

DOI:

https://doi.org/10.48165/

Keywords:

Effervescent, floating, RBZ, sustained release, tablets, ulcer

Abstract

The work aimed to formulate and assess floating tablets of Rabeprazole (RBZ) for treating peptic ulcers. Effervescent tablets were produced (F1-F9) with variations in the concentration of synthetic polymer HPMC K15 for F1, F2, and F3; natural polymer Macrocystis pyrifera extract (sodium alginate) for F4, F5, and F6; and combinations of these polymers for F7, F8, and F9. The research involved several stages, including pre-formulation studies of the pure drug. The tablets were assessed for compatibility, pre-formulation, and post formulation studies. The compatibility study indicated that there were no interfaces between drug and polymers. The floating tablets passed all the pre and post-compression constraints. Among them, F6 exhibited a drug content of 99.67 ± 0.11% and sustained drug release over 8 h. All formulations displayed favorable floating behaviour and remained afloat for more than 24 The study concludes that a combination of synthetic (HPMC K15) and natural (Macrocystis pyrifera extract) polymers found to extend the RBZ residence time in the stomach and achieve sustained drug discharge. This approach could hold promise for improving the treatment of peptic ulcers.

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