Evaluation Of Antimicrobial Properties Of Adiantum Latifolium Lam.: A Source Of Triterpenoid Leads Against Pathogenic Bacteria
DOI:
https://doi.org/10.48165/Keywords:
Adiantum latifolium, 3β-acetoxy-21α-H-hop-22(29)ene, Covid 19, FTIR, 22-hydroxyhopane, molecular dockingAbstract
Secondary bacterial infections and the emergence of drug resistant microbial strains are two consequences concomitant with COVID-19 pandemic. It demands novel antibacterial drugs to treat secondary bacterial diseases. The present study reveals that the ethyl acetate extract of the leaves of A. latifolium has antibacterial efficacy against six pathogenic bacteria, viz., Bacillus cereus, Staphylococcus aureus, Proteus mirabilis, Pseudomonas aeruginosa, Escherichia coli and Klebsiella pneumonia, reported to be infecting COVID-19 patients. Molecular docking and FTIR studies have been used to find out the lead molecules of the extract. The triterpenoids 22-hydroxyhopane and 3β acetoxy-21α-H-hop-22(29)ene have shown high binding affinity (binding that the phytocompounds present in A. latifolium may serve to combat COVID-19 associated ailments.
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Ali, J., Bangash, J.A. and Siddique, M. 2023. Comparative bioactive compounds and fourier transform infrared spectroscopic evaluation of Azadirachta indica extracts and its potential as bio fungicides against plant pathogenic fungi. International Journal of Engineering, Science and Technology, 15(1): 1-12.
Archer, K.J. and Cole, A.L.J. 1986. Cuticle, cell wall ultrastructure and disease resistance in maidenhair fern. New Phytologist, 103(2): 341-348.
Du, R.H., Liang, L.R., Yang, C.Q., Wang, W., Cao, T.Z., Li, M., Guo, G.Y., Du, J., Zheng, C.L. and Zhu, Q.l. 2020. Predictors of mortality for patients with Covid-19 pneumonia caused by SARSCoV-2: A prospective cohort study. European Respiratory Journal, 55(5): 2000524. [DOI: 10.1183/13993003.00524-2020].
Khan, T., Sankhe, K., Suvarna, V., Sherje, A., Patel, K. and Dravyakar, B. 2018. DNA gyrase inhibitors: Progress and synthesis of potent compounds as antibacterial agents. Biomedicine & Pharmacotherapy, 103: 923-938.
Kumar, R.P. and Siddique, S. 2021. 22-hydroxyhopane, a novel multitargeted phytocompound against
SARS-CoV-2 from Adiantum latifolium Lam. Natural Product Research, 36(16): 4276-4281. Lansbury, L., Lim, B., Baskaran, V. and Lim, W.S. 2020. Co-infections in people with Covid-19: A systematic review and meta-analysis. Journal of Infection, 81: 266-275.
Manohar, P., Loh, B., Nachimuthu, R., Hua, X., Welburn, S.C. and Leptihn, S. 2020. Secondary bacterial infections in patients with viral pneumonia. Frontiers in Medicine, 7: 1-8. Morris, G.M., Ruth, H., Lindstrom, W., Sanner, M.F., Belew, R.K., Goodsell, D.S. and Olson, A.J. 2009. Software news and updates AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility. Journal of Computational Chemistry, 30: 2785-2791. Osakwe, N. 2020. A case of Bacillus cereus bacteremia in a Covid-19 patient treated with steroids. IDCases, 21: e00855. [DOI: 10.1016/j.idcr.2020.e00855].
Pan, C., Chen, Y.G., Ma, X.Y., Jiang, J.H., He, F. and Zhang, Y. 2011. Phytochemical constituents and pharmacological activities of plants from the genus Adiantum: A review. Tropical Journal of Pharmaceutical Research, 10(5): 681-692.
Pradeepkumar, R., Dinesh Babu, K.V. and Evans, D.A. 2019a. Isolation, characterization and mode of action of a larvicidal compound, 22-hydroxyhopane from Adiantum latifolium Lam. against Oryctes rhinoceros Linn. Pesticide Biochemistry and Physiology, 153: 161-170.
Pradeepkumar, R., Evans, D.A. and Dinesh Babu, K.V. 2019b. Characterization of multipotent compounds from Adiantum latifolium leaves by liquid chromatography-electrospray-mass spectroscopy. Analytic Chemistry Letters, 9(5): 682-696.
Pradeepkumar, R., John, A., Kumar, P., Dinesh Babu, K.V. and Evans, D.A. 2018. Larvicidal efficacy of adiantobischrysene from Adiantum latifolium against Oryctes rhinoceros through disrupting metamorphosis and impeding microbial mediated digestion. Pest Management Science, 74(8): 1821-1828.
Sepulveda, J., Westblade, L.F., Whittier, S., Satlin, M.J., Greendyke, W.G., Aaron, J.G., Zucker, J., Dietz, D., Sobieszczyk, M. and Choi, J.J. 2020. Bacteremia and blood culture utilization during Covid-19 surge in New York city. Journal of Clinical Microbiology, 58: 00875–20. [DOI: 10.1128/JCM.00875-20].
Shafran, N., Shafran, I., Ben-Zvi, H., Sofer, S., Sheena, L., Krause, I., Shlomai, A., Goldberg, E. and Sklan, E.H. 2021. Secondary bacterial infection in Covid-19 patients is a stronger predictor for death compared to influenza patients. Scientific Reports, 11(1): 1-8.
Siddique, S. and Kumar, R.P. 2022. 3β-Acetoxy-21α-H-hop-22(29)ene, a novel multitargeted phytocompound against SARS-CoV-2: In silico screening. Journal of Biomolecular Structure and Dynamics, 41(9): 3884-3891.
Subramani, R., Narayanasamy, M. and Feussnerm, K.D. 2017. Plant-derived antimicrobials to fight against multi-drug-resistant human pathogens. 3 Biotech, 7: 172. [DOI: 10.1007/s13205-017- 0848-9].
Watanabe, T. and Kawaoka, Y. 2015. Influenza virus-host interactomes as a basis for antiviral drug development. Current Opinion in Virology, 14: 71-78.
Wrońska, N., Szlaur, M., Zawadzka, K. and Lisowska, K. 2022. The synergistic effect of triterpenoids and flavonoids - New approaches for treating bacterial infections. Molecules, 27: 847. [DOI: 10.3390/molecules27030847].
Zhang, W., Pei, J. and Lai, L. 2017. Computational multitarget drug design. Journal of Chemical Information and Modeling, 57: 403-412.
Zheng, X. and Polli, J. 2010. Identification of inhibitor concentrations to efficiently screen and measure inhibition Ki values against solute carrier transporters. European Journal of Pharmacological Sciences, 41(1): 43-52.
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