Sonographic And Histopathological Study Of Mammary Tumours In Female Dogs

Authors

  • Sandeep Saharan Department of Veterinary Surgery and Radiology,Lala Lajpat Rai University of Veterinary & Animal Sciences, Hisar – 125 004, Haryana (India)
  • Prem Singh Department of Veterinary Surgery and Radiology,Lala Lajpat Rai University of Veterinary & Animal Sciences, Hisar – 125 004, Haryana (India)
  • Ajit Singh Department of Veterinary Microbiology, Lala Lajpat Rai University of Veterinary & Animal Sciences, Hisar – 125 004, Haryana (India)
  • R P Gupta Department of Veterinary Pathology, Lala Lajpat Rai University of Veterinary & Animal Sciences, Hisar – 125 004, Haryana (India)
  • Ravi Dutt Department of Veterinary Gynaecology & Obstetrics, Lala Lajpat Rai University of Veterinary & Animal Sciences, Hisar – 125 004, Haryana (India)

DOI:

https://doi.org/10.48165/

Keywords:

Dog, histopathology, malignant, mammary tumour, ultrasonography

Abstract

The study was conducted on mammary tumour in ten female dogs which  were presented to the Veterinary Clinical Complex of the university. The female dogs were of different breeds with age ranging between 5.0 and 16.5  years (median age 10.7). The ultrasonographic images were used to evaluate the shape, size and echogenicity of mammary lesions. In ign tumours were homogenous in their internal  echogenic pattern i.e. hypoechoic. Ultrasonograms of malignant tumour  ike structure of variable sizes having hyperechoic  boundary. Excisional biopsy was taken after the surgery of these cases. Of  the clinical 10 cases, 6 were of benign whereas the rest cases were of  malignant category. Due to the request of owners of the animals, surgeries  were performed and tumours were confirmed by histopathology. There  were four cases of adenocarcinoma, two cases each of benign mixed tumours and myoepithelioma and one case each of adenoma and myxoma.  Skin sutures were removed after 12 days. Post-operativecarwas done  antibiotics (ceftriaxone + tazobactum), analgesics (meloxicam), B complex and vitamin C injections for 5 days. The study suggested that  ultrasonography alone is sufficient to diagnosebenign and malignant  

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References

Brearley, M.J. 1989. Mammary gland tumours in the dog. Practice, 11: 248-253. Cassali, G.D., Lavalle, G.E., De Nardi, A.B., Ferreira, E., Bertagnolli, A.C., Estrela-Lima, A., Alessi, A.C., Daleck, C.R., Salgado, B.S., Fernandes, C.G., Sobral, R.A., Amorim, R.L., Gamba, C.O., Damasceno, K.A., Auler, P.A., Magalhaes, G.M., Silva, J.O., Raposo, J.B., Ferreira, A.M.R., Oliveira, L.O., Malm, C., Zuccari, D.A. P.C., Tanaka, N.M., Ribeiro, L.R., Souze, C.M., Leite J.S., Soares, L. M.C., Cavalcanti, M.F., Fonteles, Z.G.C., Sehuch, I.D., Paniago, J., Oliveira, T.S., Terra, E.M., Castanheira, T.L.L., Felix, A.O.C., Gaernandes, S.C., Maia, F.C.L., Dagli, M.L.Z., Rocha, N.S., Fukumasu, H., Grandi, F., Machado, J. P., Silva, S.M.M.S., Bezerril, J.E., Farrido, E., Farvalho, G.D., Guim, T.N. and Campos, C.B. 2014. Consensus for the diagnosis, prognosis and treatment of canine mammary tumours-2013. Brazilian Journal of Veterinary Pathology, 7(2): 38-69.

Cassali, G.D. 2002. Patologias da glândula mamária. pp.119-133. In: Patologia da Reprodução dos Animais Domésticos (eds. E.F. Nascimento, and R.L. Santos). Rio de Janeiro, Guanabara Koogan, Argentina.

Cotchin, E. 1958. Mammary neoplasms of the bitch. Journal of Comparative Pathology, 68: 1-22. Fornage, B.D., Lorigan, J.G. and Andry, E. 1989. Fibroadenoma of the breast: Sonographic appearance. Radiology, 172(3): 671-675.

Guedes, P.E.B., Daniel, H.B.T., Sampaio, K.M.O.R., da Silva, E.B., Ferreira, M.L., de Lavor, M.S.L., de Oliveira Clark, R.M., Wenceslau, A.A., Said, R.A. and Silva, F.L. 2020. Clinical and ultrasonographic aspects of benign and malignant mammary tumours in female dogs. Acta Scientiae Veterinariae, 48(1723): 1-10.

Klopfleisch, R., Klose, P., Weise. C., Bondzio. A., Multhaup. G., Elinspanier. R. and Gruber, A.D. 2010. Proteome of metastatic canine mammary carcinomas: Similarities to and differences from human breast cancer. Journal of Proteome Research, 2: 6380-6391.

Kumar, P. and Parasar, M.C. 2020. Occurrence of mammary tumour in dogs. Journal of Agricultural Research Advances, 2(2): 29-32.

Lana, S.E., Rutteman, G.R. and Withrow, S.J. 2007. Tumours of mammary gland. pp. 619-636. In: Small Animal Clinical Oncology, 4th edn. (eds. S.J. Withrow and D.M. Vail). W.B. Saunders, Philadelphia, USA.

Luna, L.G. 1968. Manual of Histologic Staining Methods of Armed Forces Institute of Pathology (3rd edn.). McGraw Hill, New York, USA.

MacEwen, E.G. and Withrow, S.J. 2001. Small Animal Clinical Oncology (3rd edn.). W.B. Saunders, Philadelphia. USA.

Masciadri, N. and Ferranti, C. 2011: Benign breast lesions: Ultrasound. Journal of Ultrasound, 14: 55-65.

Sandeep Saharan et al.

Misdorp, W., Else, R.W., Hellmen, E. and Lipscomb, T.P. 1999. Histological classification of mammary tumours of the dog and the cat. pp. 11-27. In: American Registry of Pathology. Armed Forces Institute of Pathology, Washington, USA.

Moe, L. 2001. Population-based incidence of mammary tumours in some dog breeds. Journal Reproduction and Fertility, 57 (Suppl): 439-443.

Nunes, F.C., Damasceno, K.A., de Campos, C.B., Bertagnolli, A.C., Lavalle, G.E. and Cassali, G.D. 2019. Mixed tumours of the canine mammary glands: Evaluation of prognostic factors, treatment, and overall survival. Veterinary and Animal Science, 7: 100039 [https://doi.org/10.1016/j.vas.2018.09.003].

Nyman, H.T., Nielsen, O.L., Mcevoy, F.J., Lee, M.H., Martinussen, T., Hellmen, E. and Kristensen, A.T. 2006. Comparison of B-mode and doppler ultrasonographic findings with histologic featured of benign and malignant mammary tumours in dogs. American Journal of Veterinary Research, 67(6): 985-991.

O’Keefe, D.A. 1995. Tumours of the genital system and mammary glands. pp. 1699-1704. In: Veterinary Internal Medicine, (eds. S.J. Ettinger and E.C. Feldman), W.B. Saunders, Philadelphia, USA.

Paulinelli, R.R., Freitas-Júnior, R., Moreira, M.A., Moraes, V.A., Bernardes-Júnior, J.R., Vidal Cda, S., Ruiz, A.N. and Lucato, M.T. 2005. Risk of malignancy in solid breast nodules according to their sonographic features. Journal of Ultrasound in Medicine, 24: 635-641.

Payan, R. and Martin, A.C. 2008. Ultrasonographic assessment of the feline mammary gland. Journal of Feline Medicine and Surgery, 10(5): 466-471.

Rutteman, G.R., Withrow, S.J. and MacEwen, E.G. 2001. Tumours of the mammary gland. pp. 455-467. In: Small Animal Clinical Oncology (3rd edn.). WB Saunders, Philadelphia, USA. Sehgal, C.M., Weinstein, S.P., Arger, P.H. and Conant, E.F. 2006. A review of breast ultrasound. Journal of Mammary Gland Biology and Neoplasia, 11: 113-123.

Sleeckx, N., de Rooster, H., Veldhuis Kroeze, E.J., Van Ginneken, C. and Van Brantegem, L. 2011. Canine mammary tumours: An overview. Reproduction in Domestic Animals. 46: 1112-1131. Sorenmo, K.U.2003. Canine mammary gland tumours. Veterinary Clinics of North America: Small Animal Practice, 33: 573-596.

Sorenmo, K.U., Worley, D.R. and Goldschmidt, M.H. 2013. Tumours of the mammary gland. pp. 538-556. In: Withrow and MacEwen's Small Animal Clinical Oncology (5th edn.), W.B. Saunders, Philadelphia, USA. [http://dx.doi.org/10.1016/B978-1-4377-2362-5.00027-X].

Stavros, A.T., Thickman, D., Rapp, C.L., Dennis, M.A., Parker, S. H. and Sisney, G.A. 1995. Solid breast nodules: Use of sonography to distinguish between benign and malignant lesions. Radiology, 196: 123-134.

Stan, F., Gudea, A., Damian, A., Gal, A.F., Papuc, I., Alexandru Raul Pop, A.R. and Cristian M. 2020. Ultrasonographic algorithm for the assessment of sentinel lymph nodes that drain the mammary carcinomas in female dogs. Animals, 10: 2366; [doi:10.3390/ani10122366].

Tanno, T., Tanaka, Y., Sugiura, T., Akiyoshi, H., Takenaka, S., Kuwamura, M., Yamate, J., Ohashi, F., Kubo, K. and Tsuyama, S. 2006. Expression patterns of the slit subfamily mRNA in canine malignant mammary tumours. Journal of Veterinary Medical Science, 68(11): 1173-1177.

Waldron, D.R. 2001. Diagnosis and surgical management of mammary neoplasia in dogs and cats. Veterinary Medicine, 96: 943-948.

Zuki, A.B.Z. and Boyd, J.S. 2004. Ultrasonographic imaging of neoplasia of the canine mammary glands and their regional lymph nodes. Journal of Animal and Veterinary Advances, 3: 604- 612.

Published

2022-04-21

How to Cite

Sonographic And Histopathological Study Of Mammary Tumours In Female Dogs . (2022). Applied Biological Research, 24(2), 245–250. https://doi.org/10.48165/