Indian Journal of Applied Basic Medical Sciences Year: 2020, Volume: 22(B), Issue. (2) First page: (432) Last page: (439) Online ISSN: 2249-7935 Print ISSN: 0975-8917 doi: 10.48165/ijabms.2020.22235
Vitamin D Deficiency and Its Effect on Severity of Asthma in Adult Patients
Sunita j. Solanki1, Hemang Suthar2*, Bhagyashree Chaudhary3, Dhruv Parmar4
1Assistant Professor, 2Associate Professor of Medicine, 3Second year Resident Doctors, 4Second year Resident Doctors Department of medicine, smt NHL medical college & SVP Hospital , Elisbridge Ahmedabad pin 38006
Corresponding author email id: email@example.com
Online Published on 02-July-2020
AIM: This study is aimed to assess vitamin D status in asthmatic patients and to assess the relationship between vitamin D level and asthma severity. INTRODUCTION: Asthma is heterogeneous disease, usually characterized by variable airflow obstruction and bronchial hyper-responsiveness. The world health organization stated that approximately 300 million people have asthma. Recently the effects of vitamin D appear to have regulatory effect on every part of immune system, vitamin D deficiency being linked to an array of immunologically based disease focusing on asthma. METHOD: The present study included 50 patients diagnosed as bronchial asthma. The asthmatic patient group was divided into group A, asthma in between attack and group B, exacerbated asthma, that was again divided in subgroup (I), (II), and (III) mild , moderate and severe exacerbated asthma according to symptoms and FEV1. Serum 25 hydroxy vitamin D3 level in all groups was measured by radio immunoassay method and compared between these groups. RESULT: This study shows statistically significant correlation between vitamin D level and severity of asthma. The mean levels of serum 25 hydroxy vitamin D3 in asthmatic patients are: Group A-28.24 ± 1.35 ng/ml, mild persistent- 22.6 ± 11.5 ng/ml, moderate persistent – 18.33 ± 1.31 ng/ml, and severe persistent – 10.45 ± 1.84 ng/ml. P value is <0.01, which is highly significant. CONCLUSION: Lower level of vitamin D is associated with higher severity of asthma.
hydroxy, asthmatic, asthma, vitamin, exacerbated