Study Of Association Of Subclinical Hypothyroidism With Dyslipidemia

Indian Journal of Applied Basic Medical Sciences
Year: 2020, Volume: 22(A), Issue. (1)
First page: (42) Last page: (54)
Online ISSN: 2249-7935
Print ISSN: 0975-8917
doi:

Study Of Association Of Subclinical Hypothyroidism With Dyslipidemia
Sneha Shah1, M. Rafe Pathan2*, Monila N.Patel3, Ruchir Dave4, Parth H. Patel5
1Assistant professor of medicine, 2,4Resident in medicine, 3Professor, 4Associate Professor, Department of medicine, NHL Municipal Medical college & SVP Hospital Elis bridge Ahmedabad pin 380006
Corresponding author email id: m.rafe92@gmail.com


Online Published on 02-Jan-2020

ABSTRACT

INTRODUCTION: Thyroid hormones are important metabolic regulators having direct and indirect action on lipid production, disposal and efuluIt may be associated with dyslipidaemia, leading to the associated risks of coronary artery diseases and atherosclerosisu To date this has not been clearly elucidated in Indian populations which are considered to be a high risk group when it comes to Coronary Artery Diseaseu We in our study have tried to elaborate and fnd a relationship between Subclinical Hypothyroidism and Dyslipidaemiau OBJECTIVE: To study the association of subclinical hypothyroidism with dyslipidaemia using a normothyroid group as control populationu METHOD: Ours is a cross sectional observational study undertaken after approval of the Institutional Review Boardu After due consent and verifcation of the inclusion and elclusion criteria, 100 normothyroid and 100 naïve subclinical hypothyroid patients were considered for the study and their fasting lipid profle checkedu The data was compiled and after appropriate statistical analysis inferences were drawnu RESULTS: Our study demonstrated a statistically signifcant diference in the lipid profle and composition of the two groups with the Subclinical hypothyroid having a higher prevalence of dyslipidaemiauCONCLUSIONS: We were able to demonstrate signifcantly higher levels of prevalence of dyslipidaemia in the subclinical hypothyroid group as compared to the general populationu This is of interest as this group of patients are not targeted for therapyu Further research using larger data pools is required to formulate treatment goals and to evaluate the need for screening SCH patients for dyslipidaemia which may help in preventing and reducing the CAD burdenu

Keywords

subclinical hypothyroidism, dyslipidaemia, thyroid, cholesterol

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