Physiological assessment of Common Carotid Artery End Diastolic Velocity, a hemodynamic parameter, with future risk for the development of cerebrovascular stroke

Indian Journal of Applied Basic Medical Sciences
Year: 2020, Volume: 22(A), Issue. (1)
First page: (334) Last page: (339)
Online ISSN: 2249-7935
Print ISSN: 0975-8917
doi:10.48165/ijabms.2020.22132

Physiological assessment of Common Carotid Artery End Diastolic  Velocity, a hemodynamic parameter, with future risk for the  development of cerebrovascular stroke
Manisha B. Makwana1, Anand Mistri2, Vilas J. Patel3
*Tutor (Ph.D Research Student, Gujarat University ) ,2Associate Professor, 3Professor , Department of Physiology, GCS Medical College,Ahmedabad-380025 
Corresponding author email id: dranand.4.10@gmail.com

Online Published on 02-Jan-2020

ABSTRACT

Low End diastolic velocity of common carotid artery is potential hemodynamic marker of  intracranial resistance and associated with ischemic stroke.  Abstracts: Aim: Assessment of Common carotid artery end diastolic velocity , a hemodynamic  parameter, with the future risk for development of Cerebrovascular stroke . In order to assess common  carotid artery end diastolic velocity , we have evaluated age, BMI, W/H , blood pressure , lipid profile  and HbA1c in CV Stroke and control subjects. Material method: The present study was conducted on 30  CV Stroke patients(Group A) and 30 non stroke hypertensive and diabetic patients (Group B) . CCA End  diastolic velocity was assessed in each group by Doppler ultrasound machine. BMI and W/H was  measured according to WHO protocol. Blood pressure was measured by sphygmomanometer. Lipid  profile and HbA1c was done by autoanalyser machine . Result : CCA End diastolic velocity in Group A  and group B was found to be 10.49±6.02 & 17.70±4.18 and 12.59±3.47 & 21.47±5.21 in right and left  side respectively. The data was highly significant (p<0.0001).Age in Group A and B was found to be  62.8±9.11 and 53.87±10.06 respectively (p=0.0007). BMI in Group A and Group B was found to be  27.93±3.24 and 28.52±3.87 respectively (p=0.5245).W/H in Group A and Group B was 0.88±0.042 and  0.89±0.04 respectively (p=0.3489). Systolic and diastolic blood pressure in both the groups was found to  be 148.02±14.77 & 138.93±7.04 and 88.33±5.97 & 84.53 ±5.75 which was statistically significant with p  value 0.003and 0.014 respectively. The difference between mean of two groups for HbA1c ,HDL , LDL ,  triglyceride and total cholesterol in both the groups were 8.61±0.84 & 7.47±0.56, 38.7±5.42 &  49.91±8.333, 143.37±6.25 & 113.63±17.42, 136.63±12.11& 201.9±55.26 ,226.37±8.006 & 202.4±22.08  respectively which was statistically very significant(p<0.0001). Conclusion: Carotid hemodynamic  alterations expressed in Common Carotid Artery End diastolic velocity should be screened for future risk  for development of CV stroke in hypertensive and diabetic patients with advance age. These findings  need to be confirmed by a prospective study.

Keywords

CCA EDV ,CV stroke,HbA1c, HDL, LDL, Total cholesterol , triglyceride