Efficacy of Intra-Articular Dexmedetomidine for Postoperative Analgesia in Arthroscopic Knee Surgery

Indian Journal of Applied Basic Medical Sciences
Year: 2020, Volume: 22(A), Issue. (1)
First page: (64) Last page: (69)
Online ISSN: 2249-7935
Print ISSN: 0975-8917

Efficacy of Intra-Articular Dexmedetomidine for Postoperative Analgesia in Arthroscopic  Knee Surgery 
Rupal B Shah1, Pancham H Mehta2, Kinjal Patel3 , Ishita S Thaker4,  Helly Mehta5  
1Associate Professor,23rd Year Resident, 33rd Year Resident,42nd Year Resident, 51st Year Resident Department  of Anesthesia, Amc Met Medical College and Lg Hospital Ahmedabad Pin 380008  
Corresponding author email id:

Online Published on 02-Jan-2020


Introduction Post-operative pain is very common distressing symptom after any surgical procedure.Different  drugs in different routes have been used for controlling post-arthroscopic pain.We have compared the efficacy  of analgesic effect of plain ropivacaine versus ropivacaine with dexmedetomidine as an adjuvant when  administered through the intra-articular route in arthroscopic knee surgery. Materials and Methods From June 2017 to June 2019 sixty patients undergoing elective knee arthroscopy  were randomly assigned to two groups (n=30). Group R received 19 ml of 0.50% ropivacaine and 1 ml of  isotonic saline (total volume 20 ml) intraarticularly. Group RD received 100 μg (1 ml) of dexmedetomidine  added to 19 ml of 0.50% ropivacaine intra-articularly(total 20ml).Pain was assessed using visual analogue  scale(VAS) and diclofenac sodium given as rescue analgesia when VAS>4.Time of first analgesia request and  total dose of rescue analgesics used in 24 hours were calculated. Results VAS score were significantly lower in Group RD, time to first analgesic requirement was significantly  greater in Group RD than in Group R and total dose of analgesics used in Group RD patients was significantly  less compared to patients in Group R.  Conclusion Dexmedetomidine, added as adjunct to ropivacaine in patients undergoing arthroscopic knee  surgery, improves the quality and duration of postoperative analgesia.


dexmedetomidine, ropivacaine, arthroscopic knee surgery, intra-articular injection